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Phenformin hydrochloride structure, CAS 834-28-6

Phenformin hydrochloride

CAS Number834-28-6

SynonymsPhenformin hydrochloride; Phenformini Hydrochloride; Insora; meltrol; phenforminhclno.9113; Imidodicarbonimidic diamide, N-(2-phenylethyl)-, hydrochloride (1:1); Glucopostin; Phenformine HCL; dbi-td; β-PEBG HCl; DBI monohydrochloride; usafvi-6; MFCD00035039; Phenformin HCl; PhenforMin HCl API; UNII-91XC93EU03; EINECS 212-637-3; Insoral; N-(2-Phenylethyl)imidodicarbonimidic diamide hydrochloride (1:1); N-Phenethylbiguanide hydrochloride; 1-(2-Phenylethyl)biguanide hydrochloride; N'-b-Phenethylformamidinyliminourea Hydrochloride; Phenformin (hydrochloride); 1,1-Benzylmethylbiguanide hydrochloride

Molecular FormulaC10H16ClN5

Molecular Weight241.72

Purity98%

Density1.24 g/cm3

Boiling Point413.7ºC at 760 mmHg

Melting Point175-178ºC

Flash Point

Appearancewhite powder

EINECS212-637-3

MSDSChineseEnglish

Symbol6.1

Signal WordWarning

Cat. No.: 2A-9011960 Purity: 98%
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Quality Control of [ 834-28-6 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number834-28-6
Catalog No.2A-9011960
Chinese Name盐酸苯乙双胍
SynonymsPhenformin hydrochloride; Phenformini Hydrochloride; Insora; meltrol; phenforminhclno.9113; Imidodicarbonimidic diamide, N-(2-phenylethyl)-, hydrochloride (1:1); Glucopostin; Phenformine HCL; dbi-td; β-PEBG HCl; DBI monohydrochloride; usafvi-6; MFCD00035039; Phenformin HCl; PhenforMin HCl API; UNII-91XC93EU03; EINECS 212-637-3; Insoral; N-(2-Phenylethyl)imidodicarbonimidic diamide hydrochloride (1:1); N-Phenethylbiguanide hydrochloride; 1-(2-Phenylethyl)biguanide hydrochloride; N'-b-Phenethylformamidinyliminourea Hydrochloride; Phenformin (hydrochloride); 1,1-Benzylmethylbiguanide hydrochloride
Molecular FormulaC10H16ClN5
Molecular Weight241.72
Purity98
Density1.24 g/cm3
Boiling Point413.7ºC at 760 mmHg
Melting Point175-178ºC
Appearancewhite powder
Water Solubility≥10 g/100 mL at 21 ºC
Storage Condition-20°C Freezer
ApplicationPhenformin hydrochloride is a biguanide antidiabetic drug that activates AMPK.
EINECS212-637-3
HTC2942000000
PubChem ID329820259
MDL NumberMFCD00035039
SMILESCl.NC(=N)NC(=N)NCCc1ccccc1
InChI1S/C10H15N5.ClH/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H6,11,12,13,14,15);1H
InChI KeyYSUCWSWKRIOILX-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard Symbols6.1
MSDSmsds/11960_1_834_28_6.pdf
Use ofPhenformin (hydrochloride) is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class, can activate AMPK activity. Properties Name Phenformin hydrochloride Synonym More Synonyms Phenformin (hydrochloride) Biological Activity Description Phenformin (hydrochloride) is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class, can activate AMPK activity. Related Catalog Signaling Pathways >> Epigenetics >> AMPK Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Research Areas >> Cancer In Vivo Phenformin increases levels of P-eIF2α and its target BiP/Grp78 in normal lung as well as in lung tumors of mice[3]. Kinase Assay Total AMPK activity is measured using the method of Dagher et al. AMPK activity is quantified in the resuspended pellet as incorporation of 32P from [γ-32P]ATP (10 GBq/mmol) into a synthetic peptide with the specific target sequence for AMPK, the SAMS peptide. Radioactivity is measured using a liquid scintillation counter. Protein content in the solution containing the resupended (NH4)2SO4 pellet is determined using the Bradford method. References [1]. Sakamoto K, et al. Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. Am J Physiol Endocrinol Metab.?2004 Aug;287(2):E310-7. [2]. Zhang L, et al. Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H457-66. [3]. Moreira AL, et al. Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J Exp Med. 1993 Jun 1;177(6):1675-80. [5]. Dilman VM, et al. Inhibition of DMBA-induced carcinogenesis by phenformin in the mammary gland of rats. Arch Geschwulstforsch. 1978;48(1):1-8. Chemical & Physical Properties Exact Mass 241.109421 PSA 97.78000 LogP 2.72010 InChIKey YSUCWSWKRIOILX-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Biguanide, 1-phenethyl-, monohydrochloride CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : MUYZMYUM&M2R &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 17500 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Endocrine - hypoglycemia TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 17800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 24,181,1994 Safety Information Signal Word Warning Hazard Statements H302 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xn:Harmful Risk Phrases R22 Safety Phrases S36 RIDADR 2811.0 WGK Germany 3 RTECS DU2200000 Hazard Class 6.1 HS Code 2942000000 Precursor & DownStream Precursor 0 DownStream 1 CAS#:114-86-3 phenformin
Transport InfoProduct name: Phenformin hydrochloride
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