CAS Number69-57-8
SynonymsMFCD00069666; Penicillin-G, monosodium salt; Sodium Benzylpenicillin; SODIUM PENICILLIN G; Sodium Penicillin; EINECS 200-710-2; Pencillin G sodium; Penicillin; Penicillin G Sodium Salt; Nalpen G; sodium benzylpenicillinate
Molecular FormulaC16H17N2NaO4S
Molecular Weight356.37
Purity98%
Density1.41
Boiling Point663.3ºC at 760 mmHg
Melting Point209-212°C
Appearancepowder
EINECS200-710-2
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 69-57-8 |
| Catalog No. | 2A-9011915 |
| Chinese Name | 青霉素钠 |
| Synonyms | MFCD00069666; Penicillin-G, monosodium salt; Sodium Benzylpenicillin; SODIUM PENICILLIN G; Sodium Penicillin; EINECS 200-710-2; Pencillin G sodium; Penicillin; Penicillin G Sodium Salt; Nalpen G; sodium benzylpenicillinate |
| Molecular Formula | C16H17N2NaO4S |
| Molecular Weight | 356.37 |
| Purity | 98 |
| Density | 1.41 |
| Boiling Point | 663.3ºC at 760 mmHg |
| Melting Point | 209-212°C |
| Appearance | powder |
| Water Solubility | 5-10 g/100 mL at 25 ºC |
| Storage Condition | 2-8°C |
| Application | Penicillin G sodium salt is a typical β-lactam antibiotic. |
| EINECS | 200-710-2 |
| HTC | 2941109900 |
| PubChem ID | 24898384 |
| MDL Number | MFCD00069666 |
| SMILES | [Na+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O |
| InChI | 1S/C16H18N2O4S.Na/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1 |
| InChI Key | FCPVYOBCFFNJFS-LQDWTQKMSA-M |
| Beilstein/REAXYS | 3834217 |
| NACRES Code | NA.76 |
| eCl@ss | 34010400 |
| UNSPSC | 12352207 |
| MSDS | msds/11915_1_69_57_8.pdf |
| Bioactivity | Penicillin G sodium salt is a typical β-lactam antibiotic. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection In Vitro The Ultraviolet-visible (UV-Vis) absorption spectrum of the Penicillin G sodium salt-TEM-1 system is markedly different to that of Penicillin G sodium salt and TEM-1 β-lactamase, indicating the formation of new complexes between Penicillin G sodium salt and TEM-1 β-lactamase. The UV-Vis absorption of TEM-1 β-lactamase increases and a slight red-shift occurs as the concentration of Penicillin G sodium salt increasing, indicating that the interaction between Penicillin G sodium salt and TEM-1 β-lactamase results in subtle conformational changes of TEM-1 β-lactamase[1]. In Vivo In the logistic regression model, the probability of a positive swab in the control group is 1.6 times higher than that in the pigs treated with Penicillin G sodium salt (P<0.05). In the control group, the risk of a swab having 10 to 99 colonies per plate, compare to having zero per plate, is 2.3 times greater than that in the pigs treated with Penicillin G sodium salt (P=0.022)[2]. Kinase Assay At 278 K, various concentrations of Penicillin G sodium salt, cefalexin and cefoxitin solutions are added to TEM-1β-lactamase solution (5×10-6 M). The concentrations of the three antibiotics are gradually increased from 0 to 25×10-6 M. Following mixing and interaction for 2 min, the Ultraviolet-visible (UV-Vis) absorption spectra are recorded on a spectrophotometer with a slit of 2 nm and scanning speed of 400 nm/min using 0.02 M phosphate buffer (pH 7.0) as a reference[1]. Animal Admin A randomized complete block design with 2 replicates is used for this study. Each replicate includes 448 pigs, with 16 pens and 28 pigs per pen. Pigs are also sorted by weight; such that animals of similar weight based on visual observation are grouped together within blocks. Two treatments are randomly assigned within each block of 2 contiguous pens using a formal randomization process. The treatment groups are Control (no treatment given) and Treated (Penicillin G sodium salt). Penicillin G sodium salt is administered via the drinking water for 5 d over 2 periods of treatment. The first treatment period commences on the day of weaning, when the pigs are moved into the nursery barns (Day 1) and ends on Day 5. The second treatment period begins on Day 21 and ends on Day 25. The Control group does not receive treatment[2]. References [1]. Yang J, et al. Spectroscopic analysis and docking simulation on the recognition and binding of TEM-1 β-lactamase with β-lactam antibiotics. Exp Ther Med. 2017 Oct;14(4):3288-3298. [2]. Byra C, et al. Decreased mortality of weaned pigs with Streptococcus suis with the use of in-water potassium penicillin G. Can Vet J. 2011 Mar;52(3):272-6. Chemical & Physical Properties Density 1.41 Boiling Point 663.3ºC at 760 mmHg Melting Point 209-212°C Molecular Formula C16H17N2NaO4S Molecular Weight 356.372 Exact Mass 356.080658 PSA 114.84000 Index of Refraction 300 ° (C=2, H2O) InChIKey FCPVYOBCFFNJFS-LQDWTQKMSA-M SMILES CC1(C)SC2C(NC(=O)Cc3ccccc3)C(=O)N2C1C(=O)[O-].[Na+] Storage condition 2-8°C Water Solubility 5-10 g/100 mL at 25 ºC |
| Use of | Penicillin G sodium salt is a typical β-lactam antibiotic. Properties Name benzylpenicillin sodium Synonym More Synonyms Penicillin G Sodium Salt Biological Activity Description Penicillin G sodium salt is a typical β-lactam antibiotic. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection In Vitro The Ultraviolet-visible (UV-Vis) absorption spectrum of the Penicillin G sodium salt-TEM-1 system is markedly different to that of Penicillin G sodium salt and TEM-1 β-lactamase, indicating the formation of new complexes between Penicillin G sodium salt and TEM-1 β-lactamase. The UV-Vis absorption of TEM-1 β-lactamase increases and a slight red-shift occurs as the concentration of Penicillin G sodium salt increasing, indicating that the interaction between Penicillin G sodium salt and TEM-1 β-lactamase results in subtle conformational changes of TEM-1 β-lactamase[1]. References [1]. Yang J, et al. Spectroscopic analysis and docking simulation on the recognition and binding of TEM-1 β-lactamase with β-lactam antibiotics. Exp Ther Med. 2017 Oct;14(4):3288-3298. [2]. Byra C, et al. Decreased mortality of weaned pigs with Streptococcus suis with the use of in-water potassium penicillin G. Can Vet J. 2011 Mar;52(3):272-6. Chemical & Physical Properties Molecular Formula C16H17N2NaO4S Exact Mass 356.080658 PSA 114.84000 InChIKey FCPVYOBCFFNJFS-LQDWTQKMSA-M |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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