CAS Number150399-23-8
SynonymsAlimt; PeMetexed DisodiuM; PEMETREXED SODIUM; Alimta; PEMETREXED; MFCD07779402; Pemetrexed disodium; Pemwtrexed Disodium; Pemetrexed Dinatrium; Pemetrexed (disodium)
Molecular FormulaC20H19N5Na2O6
Molecular Weight597.48
Purity≥98 (HPLC)%
Boiling Point160°C 20mm
Melting Point36-38°C
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 150399-23-8 |
| Catalog No. | 2A-9011903 |
| Chinese Name | 培美曲塞二钠 |
| Synonyms | Alimt; PeMetexed DisodiuM; PEMETREXED SODIUM; Alimta; PEMETREXED; MFCD07779402; Pemetrexed disodium; Pemwtrexed Disodium; Pemetrexed Dinatrium; Pemetrexed (disodium) |
| Molecular Formula | C20H19N5Na2O6 |
| Molecular Weight | 597.48 |
| Purity | ≥98 (HPLC) |
| Boiling Point | 160°C 20mm |
| Melting Point | 36-38°C |
| Appearance | powder |
| Storage Condition | -20°C Freezer |
| Application | Pemetrexed disodium is a folate antagonist. The Ki for inhibiting thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide nucleotide formyltransferase (GARFT) are 1.3 nM, 7.2 nM and |
| HTC | 2933990090 |
| SMILES | [Na+].[Na+].[nH]1c2[nH]cc(c2[c](nc1N)=O)CCc3ccc(cc3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.O.O |
| InChI | 1S/C20H21N5O6.2Na.7H2O/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;;;;;;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;;7*1H2/q;2*+1;;;;;;;/p-2/t13-;;;;;;;;;/m0........./s1 |
| InChI Key | QJVSMHJWAOSBMD-MYXYZBIASA-L |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/11903_1_150399_23_8.pdf |
| Use of | Pemetrexed disodium is a novel antifolate that inhibits the folatedependent enzymes thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase with Kis of 1.3, 7.2, and 65 nM, respectively. Properties Name pemetrexed disodium Synonym More Synonyms Pemetrexed Biological Activity Description Pemetrexed disodium is a novel antifolate that inhibits the folatedependent enzymes thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase with Kis of 1.3, 7.2, and 65 nM, respectively. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate Signaling Pathways >> Autophagy >> Autophagy Natural Products >> Alkaloid Research Areas >> Cancer Ki: 1.3 nM (TS), 7.2 nM (DHFR), 65 nM (GARFT)[1] In Vivo The group of mice treated with PC61 plus Pemetrexed demonstrates statistically longer survival than other groups. In a survival analysis, significantly better survival is observed in the group of mice treated with PC61 plus Pemetrexed compare with those treated with PC61 alone, rat IgG plus Pemetrexed, or no treatment[2]. References [1]. Shih C, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57(6):1116-23. [2]. Anraku M, et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185(2):956-66. Chemical & Physical Properties Molecular Formula C20H19N5Na2O6 Exact Mass 471.113068 PSA 196.92000 InChIKey NYDXNILOWQXUOF-GXKRWWSZSA-L Safety Information Hazard Codes T:Toxic HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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