EN
0
Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > Paxilline
Paxilline structure, CAS 57186-25-1

Paxilline

CAS Number57186-25-1

SynonymsPAXILINE; PAXILLINE,PENICILLIUM PAXILLI; DPNI-caged-GABA; MFCD00083464; paxilline from penicillium paxilli; Paxilline 1; Paxilline

Molecular FormulaC27H33NO4

Molecular Weight435.555

Purity98%

Density1.3±0.1 g/cm3

Boiling Point648.8±55.0 °C at 760 mmHg

Melting Point252ºC

Flash Point

Appearancebuffered aqueous solution

EINECS

MSDSChineseEnglish

Symbol6.1(b)

Signal WordWarning

Cat. No.: 2A-9011886 Purity: 98%
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 57186-25-1 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number57186-25-1
Catalog No.2A-9011886
Chinese Name蕈青霉素
SynonymsPAXILINE; PAXILLINE,PENICILLIUM PAXILLI; DPNI-caged-GABA; MFCD00083464; paxilline from penicillium paxilli; Paxilline 1; Paxilline
Molecular FormulaC27H33NO4
Molecular Weight435.555
Purity98
Density1.3±0.1 g/cm3
Boiling Point648.8±55.0 °C at 760 mmHg
Melting Point252ºC
Appearancebuffered aqueous solution
Water SolubilitySoluble in DMSO, acetone or chloroform.
Storage ConditionSealed in a cool, dry environment of 2-8ºC
PackagingIII
ApplicationPaxilline is an indole alkaloid mycotoxin from Penicillium paxilli that effectively inhibits BK channels through a channel-blocking mechanism. Paxilline can also inhibit sarcoplasmic reticulum Ca2+-st
HTC29419090
MDL NumberMFCD00212475
SMILESCC(C)(O)C1OC2CCC3(C)C(O)(CCC4Cc5c([nH]c6ccccc56)C43C)C2=CC1=O
InChIInChI=1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1
InChI KeyACNHBCIZLNNLRS-FHHRXKHGSA-N
NACRES CodeNA.41
UNSPSC12352203
Hazard Symbols6.1(b)
MSDSmsds/11886_1_57186_25_1.pdf
BioactivityPaxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50s between 5μM and 50μM for differing isoforms. Paxilline possesses significant anticonvulsant activity[1][2][3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease Target IC50: 5-50 μM (SERCA)[2], BK channel[1] References [1]. Zhou Y, et al. Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism. J Gen Physiol. 2014 Nov;144(5):415-40. [2]. Bilmen JG, et al. The mechanism of inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase by paxilline. Arch Biochem Biophys. 2002 Oct 1;406(1):55-64. [3]. Sheehan JJ, et al. Anticonvulsant effects of the BK-channel antagonist paxilline. Epilepsia. 2009 Apr;50(4):711-20. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 648.8±55.0 °C at 760 mmHg Melting Point 252ºC Molecular Formula C27H33NO4 Molecular Weight 435.555 Flash Point 346.2±31.5 °C Exact Mass 435.240967 PSA 82.55000 LogP 3.77 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.661 InChIKey ACNHBCIZLNNLRS-FHHRXKHGSA-N SMILES CC(C)(O)C1OC2CCC3(C)C(O)(CCC4Cc5c([nH]c6ccccc56)C43C)C2=CC1=O Storage condition 2-8°C Water Solubility Soluble in DMSO, acetone or chloroform.
Use ofPaxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50s between 5μM and 50μM for differing isoforms. Paxilline possesses significant anticonvulsant activity[1][2][3]. Properties Articles33 Synonym More Synonyms Paxilline Biological Activity Description Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50s between 5μM and 50μM for differing isoforms. Paxilline possesses significant anticonvulsant activity[1][2][3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease IC50: 5-50 μM (SERCA)[2], BK channel[1] References [1]. Zhou Y, et al. Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism. J Gen Physiol. 2014 Nov;144(5):415-40. [2]. Bilmen JG, et al. The mechanism of inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase by paxilline. Arch Biochem Biophys. 2002 Oct 1;406(1):55-64. [3]. Sheehan JJ, et al. Anticonvulsant effects of the BK-channel antagonist paxilline. Epilepsia. 2009 Apr;50(4):711-20. Chemical & Physical Properties Molecular Formula C27H33NO4 Exact Mass 435.240967 PSA 82.55000 Index of Refraction 1.661 InChIKey ACNHBCIZLNNLRS-FHHRXKHGSA-N Water Solubility Soluble in DMSO, acetone or chloroform.
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Paxilline from Penicillium paxilli) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (Paxilline from Penicillium paxilli) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Paxilline from Penicillium paxilli) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
Related Products in Specialty Chemicals
Parbendazole14255-87-92A-9011878
Pargolol47082-97-32A-9011879
Pariphyllin2A-3029632A-9011880
Parodilol103238-56-82A-9011881
Paxamate5579-05-52A-9011885
Pazinaclone103255-66-92A-9011887
Pazufloxacin127045-41-42A-9011888
Pazufloxacin mesilate163680-77-12A-9011889
p-Chlorophenol106-48-92A-9011890
Pebulate1114-71-22A-9011891
Browse all Specialty Chemicals products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA