CAS Number163680-77-1
SynonymsPazufloxacin mesylate; MFCD00913262; Pazufloxacin Methanesulfonate; Pazufloxacin mesilate; Pazufloxacin (mesylate)
Molecular FormulaC17H19FN2O7S
Molecular Weight414.405
Purity98%
Boiling Point531.5ºC at 760 mmHg
Melting Point>255°C (dec.)
Appearancecrystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 163680-77-1 |
| Catalog No. | 2A-9011889 |
| Chinese Name | 甲磺酸帕珠沙星 |
| Synonyms | Pazufloxacin mesylate; MFCD00913262; Pazufloxacin Methanesulfonate; Pazufloxacin mesilate; Pazufloxacin (mesylate) |
| Molecular Formula | C17H19FN2O7S |
| Molecular Weight | 414.405 |
| Purity | 98 |
| Boiling Point | 531.5ºC at 760 mmHg |
| Melting Point | >255°C (dec.) |
| Appearance | crystalline solid |
| Water Solubility | Water solubility: completely soluble; soluble in: |
| Storage Condition | -20°C Freezer |
| Application | Pazufloxacin (T-3761) mesylate is a quinolone antibiotic. |
| SMILES | CC1COc2c(C3(N)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23.CS(=O)(=O)O |
| InChI Key | UDHGFPATQWQARM-FJXQXJEOSA-N |
| MSDS | msds/11889_2_163680_77_1.pdf |
| Bioactivity | Pazufloxacin (T-3761) mesylate is a fluoroquinolone antibiotic.Target: AntibacterialPazufloxacin (T-3761), a new quinolone derivative, showed broad and potent antibacterial activity. T-3761 showed good efficacy in mice against systemic, pulmonary, and urinary tract infections with gram-positive and gram-negative bacteria, including quinolone-resistant Serratia marcescens and Pseudomonas aeruginosa. The in vivo activity of T-3761 was comparable to or greater than those of ofloxacin, ciprofloxacin, norfloxacin, and tosufloxacin against most infection models in mice. The activities of T-3761 were lower than those of tosufloxacin against gram-positive bacterial systemic and pulmonary infections in mice but not against infections with methicillin-resistant Staphylococcus aureus [1]. T-3761 had a broad spectrum of activity and had potent activity against gram-positive and -negative bacteria. The MICs of T-3761 against 90% of the methicillin-susceptible Staphylococcus aureus, methicillin-susceptible and -resistant Staphylococcus epidermidis, and Clostridium spp. tested were 0.39 to 6.25 micrograms/ml. The MBCs of T-3761 were either equal to or twofold greater than the MICs. The 50% inhibitory concentrations of T-3761 for DNA gyrases isolated from E. coli and P. aeruginosa were 0.88 and 1.9 micrograms/ml, respectively [2]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Fukuoka, Y., et al., In vitro and in vivo antibacterial activities of T-3761, a new quinolone derivative. Antimicrob Agents Chemother, 1993. 37(3): p. 384-92. [2]. Muratani, T., M. Inoue, and S. Mitsuhashi, In vitro activity of T-3761, a new fluoroquinolone. Antimicrob Agents Chemother, 1992. 36(10): p. 2293-303. Chemical & Physical Properties Boiling Point 531.5ºC at 760 mmHg Melting Point >255°C (dec.) Molecular Formula C17H19FN2O7S Molecular Weight 414.405 Flash Point 275.2ºC Exact Mass 414.089691 PSA 157.30000 LogP 3.02510 Vapour Pressure 4E-12mmHg at 25°C InChIKey UDHGFPATQWQARM-FJXQXJEOSA-N SMILES CC1COc2c(C3(N)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23.CS(=O)(=O)O Storage condition -20°C Freezer |
| Use of | Properties Name Pazufloxacin Mesylate Synonym More Synonyms Pazufloxacin mesylate Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Fukuoka, Y., et al., In vitro and in vivo antibacterial activities of T-3761, a new quinolone derivative. Antimicrob Agents Chemother, 1993. 37(3): p. 384-92. [2]. Muratani, T., M. Inoue, and S. Mitsuhashi, In vitro activity of T-3761, a new fluoroquinolone. Antimicrob Agents Chemother, 1992. 36(10): p. 2293-303. Chemical & Physical Properties Molecular Formula C17H19FN2O7S Exact Mass 414.089691 PSA 157.30000 LogP 3.02510 InChIKey UDHGFPATQWQARM-FJXQXJEOSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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