CAS Number492-08-0
Synonyms[7S-(7a,7aa,14a,14ab)]-Dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine; [7S-(7α,7aα,14α,14aβ)]-Dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine; (1S,2R,9S,10S)-7,15-Diazatetracyclo[7.7.1.0.0]heptadecane; Sparteine, (+)-Isomer; lupinidine; sparteine; Pachycarpine; (7α,9α)-Sparteine
Molecular FormulaC15H26N2
Molecular Weight234.38
Purity98%
Density1.1±0.1 g/cm3
Boiling Point340.9±10.0 °C at 760 mmHg
Melting Point201ºC
AppearanceLiquid;Colorless to Light orange to Yellow clear liquid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 492-08-0 |
| Catalog No. | 2A-9011849 |
| Chinese Name | (+)-鹰爪豆碱 |
| Synonyms | [7S-(7a,7aa,14a,14ab)]-Dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine; [7S-(7α,7aα,14α,14aβ)]-Dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine; (1S,2R,9S,10S)-7,15-Diazatetracyclo[7.7.1.0.0]heptadecane; Sparteine, (+)-Isomer; lupinidine; sparteine; Pachycarpine; (7α,9α)-Sparteine |
| Molecular Formula | C15H26N2 |
| Molecular Weight | 234.38 |
| Purity | 98 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 340.9±10.0 °C at 760 mmHg |
| Melting Point | 201ºC |
| Appearance | Liquid;Colorless to Light orange to Yellow clear liquid |
| Water Solubility | Slightly soluble: ethanol |
| Storage Condition | 0-10°C; store in inert gas; avoid air, heat |
| Application | (+)-Sparteine is a natural alkaloid that acts as a ganglion blocker. In nerve cells, (+)-Sparteine competitively inhibits nicotinic acetylcholine receptor (nACh receptor) activity. |
| MDL Number | C15H26N2 |
| SMILES | C1CCN2CC3CC(CN4CCCCC34)C2C1 |
| InChI | InChI=1S/C15H26N2/c1-3-7-16-11-13-9-12(14(16)5-1)10-17-8-4-2-6-15(13)17/h12-15H,1-11H2/t12-,13-,14-,15+/m1/s1 |
| InChI Key | SLRCCWJSBJZJBV-TUVASFSCSA-N |
| MSDS | msds/11849_1_492_08_0.pdf |
| Bioactivity | (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Natural Products >> Alkaloid Research Areas >> Neurological Disease Target AChR[1] In Vitro (+)-Sparteine (2 μM) reduces the ACh-induced current caused by activation of nicotinic AChRs in a voltage-independent manner. (+)-Sparteine (5, 10 μM) reduces the amplitude of the excitatory postsynaptic current (EPSC) and the time constant of the EPSC decay[1]. References [1]. Voitenko S, et al. Effect of (+)-sparteine on nicotinic acetylcholine receptors in the neurons of rat superior cervical ganglion. Mol Pharmacol. 1991 Aug;40(2):180-5. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 340.9±10.0 °C at 760 mmHg Melting Point 201ºC Molecular Formula C15H26N2 Molecular Weight 234.380 Flash Point 148.3±6.8 °C Exact Mass 234.209595 PSA 6.48000 LogP 3.21 Vapour Pressure 0.0±0.7 mmHg at 25°C Index of Refraction 1.570 InChIKey SLRCCWJSBJZJBV-TUVASFSCSA-N SMILES C1CCN2CC3CC(CN4CCCCC34)C2C1 |
| Use of | (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons. Properties Name (+)-Sparteine Synonym More Synonyms Pachycarpine Biological Activity Description (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Natural Products >> Alkaloid Research Areas >> Neurological Disease In Vitro (+)-Sparteine (2 μM) reduces the ACh-induced current caused by activation of nicotinic AChRs in a voltage-independent manner. (+)-Sparteine (5, 10 μM) reduces the amplitude of the excitatory postsynaptic current (EPSC) and the time constant of the EPSC decay[1]. References [1]. Voitenko S, et al. Effect of (+)-sparteine on nicotinic acetylcholine receptors in the neurons of rat superior cervical ganglion. Mol Pharmacol. 1991 Aug;40(2):180-5. Chemical & Physical Properties Molecular Formula C15H26N2 Exact Mass 234.209595 PSA 6.48000 Index of Refraction 1.570 InChIKey SLRCCWJSBJZJBV-TUVASFSCSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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