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Oxiconazole nitrate structure, CAS 64211-46-7

Oxiconazole nitrate

CAS Number64211-46-7

SynonymsMFCD00865580; Oxiconazole nitrate; (1Z)-N-(2,4-Dichlorophenoxy)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanimine nitrate (1:1); EINECS 264-730-3; (z)-1-(2-(2,4-dichlorophenyl)-2-(((2,4-dichlorophenyl)oxy)imino)ethyl)-1h-IMIDAZOLE mononitrate

Molecular FormulaC18H14Cl4N4O4

Molecular Weight492.14

Purity99%

Density

Boiling Point576.8ºC

Melting Point137-1380C

Flash Point

Appearancecrystalline solid

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9011822 Purity: 99%
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Quality Control of [ 64211-46-7 ] Purity: 99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number64211-46-7
Catalog No.2A-9011822
Chinese Name硝酸奥昔康唑
SynonymsMFCD00865580; Oxiconazole nitrate; (1Z)-N-(2,4-Dichlorophenoxy)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanimine nitrate (1:1); EINECS 264-730-3; (z)-1-(2-(2,4-dichlorophenyl)-2-(((2,4-dichlorophenyl)oxy)imino)ethyl)-1h-IMIDAZOLE mononitrate
Molecular FormulaC18H14Cl4N4O4
Molecular Weight492.14
Purity99
Boiling Point576.8ºC
Melting Point137-1380C
Appearancecrystalline solid
Storage ConditionRefrigerator
ApplicationOxiconazole nitrate is a broad-spectrum antifungal drug that inhibits the growth of T. tonsurans and T. rubrum with MIC90 values ​​of 0.25 and 0.5 μg/mL, respectively.
HTC29335995
MDL NumberMFCD01727545
SMILESClc1ccc(CON=C(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1.O=[N+]([O-])O
InChI1S/C18H13Cl4N3O.HNO3/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11H,9-10H2;(H,2,3,4)/b24-18+;
InChI KeyWVNOAGNOIPTWPT-NDUABGMUSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/11822_1_64211_46_7.pdf
Use ofOxiconazole nitrate is a broad spectrum antifungal which can inhibit the growth of T. tonsurans and T. rubrum with MIC90s of 0.25 and 0.5 μg/mL, respectively. Properties Name oxiconazole nitrate Synonym More Synonyms Oxiconazole nitrate Biological Activity Description Oxiconazole nitrate is a broad spectrum antifungal which can inhibit the growth of T. tonsurans and T. rubrum with MIC90s of 0.25 and 0.5 μg/mL, respectively. Related Catalog Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection MIC90: 0.25 μg/mL (T. tonsurans), 0.5 μg/mL (T. rubrum)[1] In Vitro Oxiconazole nitrate is the more active compound in tests with T. tonsurans and T. rubrum. Twelve isolates are inhibited by 0.063 μg/mL of oxiconazole; corresponding econazole MICs range from 0.063 (three isolates) to 8 (two isolates) μg/mL. Three isolates have oxiconazole MICs of 16 or 32 μg/mL[1]. In Vivo The baseline distortion product otoacoustic emission (DPOAE) results of the right ears of all animals tested are normal. Animals in groups I, II, IV and V show no statistically significant change in the DPOAE amplitudes. The rats in the gentamicingroup show a significant decrease[2]. References [1]. Shadomy S, et al. Further in vitro studies with oxiconazole nitrate. Diagn Microbiol Infect Dis. 1988 Apr;9(4):231-7. [2]. Özdemir S, et al. Effects of topical oxiconazole and boric acid in alcohol solutions to rat inner ears. Otolaryngol Head Neck Surg. 2013 Jun;148(6):1023-7. Chemical & Physical Properties PSA 105.46000 LogP 6.15550 InChIKey WVNOAGNOIPTWPT-UHFFFAOYSA-N Storage condition Refrigerator Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-, o-((2,4-dichlorophenyl)methyl)oxime, nitrate, (Z)- CAS REGISTRY NUMBER : 64211-46-7 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C18-H13-Cl4-N3-O.H-N-O3 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 37,1355,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 17,365,1986 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,227,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 17,365,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 17,365,1986 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,227,1990 Safety Information Hazard Codes Xi RIDADR NONH for all modes of transport WGK Germany 2 RTECS CQ7700000 HS Code 29335995
Transport InfoProduct Name: Oxyconazole Nitrate
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