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Oxomemazine

Name: Oxomemazine
Brand: 2A Biotech
SKU: 2A-9011827

CAS Number3689-50-7

SynonymsN,N,b-Trimethyl-10H-phenothiazine-10-propanamine 5,5-Dioxide; EINECS 222-996-8; Oxomemazine [INN:DCF]; 3-(5,5-dioxido-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine; 3-(9,9-Dioxo-10-phenothiazinyl)-2-methyl-1-dimethylaminopropane; Oxomemazine; 3-(5,5-Dioxido-10H-phenothiazin-10-yl)-N,N,2-trimethyl-1-propanamine; 10-(3-Dimethylamino-2-methylpropyl)phenothiazine 5,5-Dioxide; RP 6847; Dysedon; 10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-, 5,5-dioxide; Dioxo-5.5-(2'-methyl-3'dimethylamino-propyl)-10 phenothiazin Oxomemazin Doxergan; 10-(3-(Dimethylamino)-2-methylpropyl)phenothiazine 5,5-dioxide

Molecular FormulaC18H22N2O2S

Molecular Weight330.45

Purity98%

Density1.2±0.1 g/cm3

Boiling Point492.4±34.0 °C at 760 mmHg

MSDSChinese English

Cat. No.: 2A-9011827 Purity: 98%

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Quality Control of [ 3689-50-7 ] Purity: 98% SDS Specification MoL

Chemical & Physical Properties
CAS Number	3689-50-7
Catalog No.	2A-9011827
Chinese Name	奥索马嗪
Synonyms	N,N,b-Trimethyl-10H-phenothiazine-10-propanamine 5,5-Dioxide; EINECS 222-996-8; Oxomemazine [INN:DCF]; 3-(5,5-dioxido-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine; 3-(9,9-Dioxo-10-phenothiazinyl)-2-methyl-1-dimethylaminopropane; Oxomemazine; 3-(5,5-Dioxido-10H-phenothiazin-10-yl)-N,N,2-trimethyl-1-propanamine; 10-(3-Dimethylamino-2-methylpropyl)phenothiazine 5,5-Dioxide; RP 6847; Dysedon; 10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-, 5,5-dioxide; Dioxo-5.5-(2'-methyl-3'dimethylamino-propyl)-10 phenothiazin Oxomemazin Doxergan; 10-(3-(Dimethylamino)-2-methylpropyl)phenothiazine 5,5-dioxide
Molecular Formula	C18H22N2O2S
Molecular Weight	330.45
Purity	98
Density	1.2±0.1 g/cm3
Boiling Point	492.4±34.0 °C at 760 mmHg
Storage Condition	Room temperature, sealed, dry
Application	Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with significant antimuscarinic activity. Oxomemazine is a selective antagonist of the histamine M1 receptor, showing a 20-fold diffe
HTC	2934300000
MDL Number	C18H22N2O2S
SMILES	CC(CN(C)C)CN1c2ccccc2S(=O)(=O)c2ccccc21
InChI	InChI=1S/C18H22N2O2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)23(21,22)18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3
InChI Key	QTQPVLDZQVPLGV-UHFFFAOYSA-N
MSDS	msds/11827_1_3689_50_7.pdf
Use of	Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties. Oxomemazine is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki = 84 nM, M1 receptor) and low (Ki = 1.65 μM, M2 receptor) affinity sites[1]. Oxomemazine an antihistamine and anticholinergic agent used for the study of cough treatment[2]. Properties Name 3-(5,5-dioxophenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine Synonym More Synonyms Oxomemazine Biological Activity Description Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties. Oxomemazine is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki = 84 nM, M1 receptor) and low (Ki = 1.65 μM, M2 receptor) affinity sites[1]. Oxomemazine an antihistamine and anticholinergic agent used for the study of cough treatment[2]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> mGluR Signaling Pathways >> GPCR/G Protein >> Histamine Receptor H1 Receptor mGluR 1:84 nM (Ki) mGluR2:1.65 μM (Ki) References [2]. M S Siddegowda, et al.Oxomemazine hydro-chloride. Acta Crystallogr Sect E Struct Rep Online. 2011 Aug 1;67(Pt 8):o1875. Chemical & Physical Properties Molecular Formula C18H22N2O2S Exact Mass 330.140198 PSA 49.00000 Index of Refraction 1.598 InChIKey QTQPVLDZQVPLGV-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-, 5,5-dioxide CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C18-H22-N2-O2-S MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T C666 BN ISWJ B1Y1&1N1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit REFERENCE : FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982 TYPE OF TEST : Rinsed with water ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit REFERENCE : FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982 ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,1203,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - irritability Skin and Appendages - hair REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 57,460,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 135,364,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 135,364,1962 * REVIEWS * TOXICOLOGY REVIEW TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 15,57,1977 Safety Information HS Code 2934300000
Tax Rebate	13.0%
Supervision	None. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport Info	Product name: Summary 2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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