CAS Number60607-34-3
SynonymsOxatomidum; MFCD00211147; KW-4354; EINECS 262-320-9; Oxatomida; Oxatomidum [INN-Latin]; oxatomide; 1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one; Oxetal; Tinset; Oxatimide; Celtect
Molecular FormulaC27H30N4O
Molecular Weight426.55
Purity≥99%
Density1.175 g/cm3
Boiling Point621.1ºC at 760 mmHg
Melting Point153.60C
Appearancepowder
EINECS262-320-9
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 60607-34-3 |
| Catalog No. | 2A-9011812 |
| Chinese Name | 奥沙米特 |
| Synonyms | Oxatomidum; MFCD00211147; KW-4354; EINECS 262-320-9; Oxatomida; Oxatomidum [INN-Latin]; oxatomide; 1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one; Oxetal; Tinset; Oxatimide; Celtect |
| Molecular Formula | C27H30N4O |
| Molecular Weight | 426.55 |
| Purity | ≥99 |
| Density | 1.175 g/cm3 |
| Boiling Point | 621.1ºC at 760 mmHg |
| Melting Point | 153.60C |
| Appearance | powder |
| Water Solubility | DMSO: soluble |
| Storage Condition | Store in a sealed container in a cool, dry place |
| Application | Oxatomide is a potent, orally active, dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity. Oxatomide almost completely blocks ATP-induced currents in t |
| EINECS | 262-320-9 |
| HTC | 2933990090 |
| PubChem ID | 24278615 |
| MDL Number | MFCD00211147 |
| SMILES | O=C1Nc2ccccc2N1CCCN3CCN(CC3)C(c4ccccc4)c5ccccc5 |
| InChI | 1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32) |
| InChI Key | BAINIUMDFURPJM-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 51111800 |
| Hazard Symbols | Transport |
| MSDS | msds/11812_1_60607_34_3.pdf |
| Bioactivity | Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin[1][2]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Target H1 Receptor P2X7 serotonin References [1]. Kazuki Yoshida, et al. P2X7 receptor antagonist activity of the anti-allergic agent oxatomide. Eur J Pharmacol. 2015 Nov 15;767:41-51. [2]. K Ohmori, et al. Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators. Nihon Yakurigaku Zasshi. 1983 May;81(5):399-409. Chemical & Physical Properties Density 1.175 g/cm3 Boiling Point 621.1ºC at 760 mmHg Melting Point 153.60C Molecular Formula C27H30N4O Molecular Weight 426.55300 Flash Point 329.4ºC Exact Mass 426.24200 PSA 44.27000 LogP 4.00270 Index of Refraction 1.619 InChIKey BAINIUMDFURPJM-UHFFFAOYSA-N SMILES O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 Storage condition Refrigerator Water Solubility DMSO: soluble |
| Use of | Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin[1][2]. Properties Articles34 Name 3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one Synonym More Synonyms Oxatomide Biological Activity Description Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin[1][2]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor H1 Receptor References [1]. Kazuki Yoshida, et al. P2X7 receptor antagonist activity of the anti-allergic agent oxatomide. Eur J Pharmacol. 2015 Nov 15;767:41-51. [2]. K Ohmori, et al. Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators. Nihon Yakurigaku Zasshi. 1983 May;81(5):399-409. Chemical & Physical Properties Molecular Formula C27H30N4O Exact Mass 426.24200 PSA 44.27000 LogP 4.00270 Index of Refraction 1.619 InChIKey BAINIUMDFURPJM-UHFFFAOYSA-N Storage condition Refrigerator Water Solubility DMSO: soluble |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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