CAS Number151720-43-3
Synonyms(2E)-N-hydroxy-5-{3-[(phenylsulfonyl)amino]phenyl}pent-2-en-4-ynamide; (2E)-N-Hydroxy-5-{3-[(phenylsulfonyl)amino]phenyl}-2-penten-4-ynamide; (2E)-5-[3-(Phenylsulfonylamino)phenyl]-pent-2-en-4-ynohydroxamic acid; (E)-5-[3-(benzenesulfonamido)phenyl]-N-hydroxypent-2-en-4-ynamide
Molecular FormulaC17H14N2O4S
Molecular Weight342.37
Purity≥98 (HPLC)%
Density1.4±0.1 g/cm3
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 151720-43-3 |
| Catalog No. | 2A-9011807 |
| Chinese Name | Oxamflatin |
| Synonyms | (2E)-N-hydroxy-5-{3-[(phenylsulfonyl)amino]phenyl}pent-2-en-4-ynamide; (2E)-N-Hydroxy-5-{3-[(phenylsulfonyl)amino]phenyl}-2-penten-4-ynamide; (2E)-5-[3-(Phenylsulfonylamino)phenyl]-pent-2-en-4-ynohydroxamic acid; (E)-5-[3-(benzenesulfonamido)phenyl]-N-hydroxypent-2-en-4-ynamide |
| Molecular Formula | C17H14N2O4S |
| Molecular Weight | 342.37 |
| Purity | ≥98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Appearance | solid |
| Storage Condition | 2-8℃ |
| Application | Oxamflatin (Metacept-3) is a highly potent HDAC inhibitor with an IC50 value of 15.7 nM. |
| HTC | 2935009090 |
| PubChem ID | 329818905 |
| MDL Number | MFCD00949087 |
| SMILES | ONC(=O)\C=C\C#Cc1cccc(NS(=O)(=O)c2ccccc2)c1 |
| InChI | 1S/C17H14N2O4S/c20-17(18-21)12-5-4-7-14-8-6-9-15(13-14)19-24(22,23)16-10-2-1-3-11-16/h1-3,5-6,8-13,19,21H,(H,18,20)/b12-5+ |
| InChI Key | QRPSQQUYPMFERG-LFYBBSHMSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352203 |
| MSDS | msds/11807_1_151720_43_3.pdf |
| Use of | Oxamflatin (Metacept-3) is a potent HDAC inhibitor with an IC50 of 15.7 nM. Properties Name Oxamflatin Synonym More Synonyms Oxamflatin Biological Activity Description Oxamflatin (Metacept-3) is a potent HDAC inhibitor with an IC50 of 15.7 nM. Related Catalog Research Areas >> Cancer HDAC:15.7 nM (IC50) Cell Assay Cells grown in DMEM supplemented with 10% fetal bovine serum are challenged with serial two fold dilutions of oxamflatin on day 1 after the cells are seeded, and incubated for 2 days for the suspension cell cultures and for 3 days for the adherent cell cultures. Inhibition of the cell growth by oxamflatin is determined by staining with MTT as described previously[1]. References [1]. Kim YB, et al. Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase. Oncogene. 1999 Apr 15;18(15):2461-70. [2]. Wang YL, et al. HDAC Inhibitor Oxamflatin Induces Morphological Changes and has Strong Cytostatic Effects in Ovarian Cancer Cell Lines. Curr Mol Med. 2016;16(3):232-42. [3]. Faghihloo E, et al. The effect of oxamflatin on the E-cadherin expression in gastric cancer cell line. Cancer Gene Ther. 2016 Nov;23(11):396-399. Chemical & Physical Properties Molecular Formula C17H14N2O4S Exact Mass 342.067413 PSA 103.88000 Index of Refraction 1.686 InChIKey QRPSQQUYPMFERG-LFYBBSHMSA-N Storage condition 2-8℃ Safety Information Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter Safety Phrases S22 RIDADR NONH for all modes of transport HS Code 2935009090 Synthetic Route Dehydroxyamino ... CAS#:151720-90-0 Oxamflatin CAS#:151720-43-3 Literature: Journal of Medicinal Chemistry, , vol. 39, # 15 p. 2871 - 2873 tert-Butyl (3-i... CAS#:143390-49-2 Oxamflatin CAS#:151720-43-3 Literature: Journal of Medicinal Chemistry, , vol. 39, # 15 p. 2871 - 2873 CAS#:151721-61-8 Oxamflatin CAS#:151720-43-3 Literature: Journal of Medicinal Chemistry, , vol. 39, # 15 p. 2871 - 2873 Precursor & DownStream Precursor 4 CAS#:151720-90-0 Dehydroxyamino ... CAS#:143390-49-2 tert-Butyl (3-i... CAS#:151721-61-8 CAS#:151720-89-7 DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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