CAS Number315-72-0
SynonymsN-<3-<4-(2-Hydroxyoxyethyl)-piperazino>propyl>-2,2'-iminostilben; Opipramol; 4-[3-(5H-Dibenz[b,f]azepin-5-yl)-propyl]-1-piperazineethanol; 2-[4-(3-dibenzo[b,f]azepin-5-yl-propyl)-piperazin-1-yl]-ethanol; Insidon; Opipramolum [INN-Latin]; opipramol hydrochloride; [3H]-Opipramol; EINECS 206-254-0; Opipramol [INN:BAN]; Opipramol G; Nisidana
Molecular FormulaC23H29N3O
Molecular Weight363.5
Purity98%
Density1.129 g/cm3
Boiling Point555.1ºC at 760 mmHg
Melting Point100-101ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 315-72-0 |
| Catalog No. | 2A-9011777 |
| Chinese Name | 息顿 |
| Synonyms | N-<3-<4-(2-Hydroxyoxyethyl)-piperazino>propyl>-2,2'-iminostilben; Opipramol; 4-[3-(5H-Dibenz[b,f]azepin-5-yl)-propyl]-1-piperazineethanol; 2-[4-(3-dibenzo[b,f]azepin-5-yl-propyl)-piperazin-1-yl]-ethanol; Insidon; Opipramolum [INN-Latin]; opipramol hydrochloride; [3H]-Opipramol; EINECS 206-254-0; Opipramol [INN:BAN]; Opipramol G; Nisidana |
| Molecular Formula | C23H29N3O |
| Molecular Weight | 363.5 |
| Purity | 98 |
| Density | 1.129 g/cm3 |
| Boiling Point | 555.1ºC at 760 mmHg |
| Melting Point | 100-101ºC |
| Storage Condition | -20°C Freezer |
| Application | Ensidon is an atypical tricyclic antidepressant (TCA). Opramole mainly acts as a sigma (σ) receptor agonist and can effectively interact with the sigma recognition site with a Ki value of 50nM. Opramo |
| HTC | 2933990090 |
| MDL Number | C23H29N3O |
| SMILES | OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1 |
| InChI | InChI=1S/C23H29N3O/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26/h1-4,6-11,27H,5,12-19H2 |
| InChI Key | YNZFUWZUGRBMHL-UHFFFAOYSA-N |
| MSDS | msds/11777_1_315_72_0.pdf |
| Use of | Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD)[1][2]. Properties Name 2-[4-(3-benzo[b][1]benzazepin-11-ylpropyl)piperazin-1-yl]ethanol Synonym More Synonyms opipramol Biological Activity Description Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD)[1][2]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor Ki: 50 nM (σ receptor); IC50: 5.5 μM ([3H] DA)[1]. In Vitro Opipramol can potently interact with sigma recognition sites with a Ki value of 50 nM[1]. Opipramol inhibit the uptake of [3H] DA in crude synaptosomal preparations with an IC50 value of 5.5 μM[1]. Chemical & Physical Properties Molecular Formula C23H29N3O Exact Mass 363.23100 PSA 29.95000 LogP 3.24930 Index of Refraction 1.6500 (estimate) InChIKey YNZFUWZUGRBMHL-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1-Piperazineethanol, 4-(3-(5H-dibenz(b,f)azepin-5-yl)propyl)- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C23-H29-N3-O MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T C676 BNJ B3- AT6N DNTJ D2Q HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 148,560,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 148,560,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 148,560,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 181,68,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 148,560,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 148,560,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 148,560,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 148,560,1964 Safety Information GHS07, GHS09 Signal Word Warning Hazard Statements H302-H410 Precautionary Statements P273-P501 Hazard Codes Xn,N Safety Phrases 60-61 RTECS TL8750000 HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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