CAS Number73590-58-6
Synonyms5-methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)-methylsulfinyl]benzimidazole; 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole; Omepral; (RS)-5-Methoxy-2-(4-methoxy-3,5-dimethyl-2-pyridylmethylsulphinyl)benzimidazole; elgam; ANTRA; MEPRAL; Zoltum; PRILOSEC; (-)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole; zimor; Losec; Omeprazen; Pepticum; prysma; 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole; EINECS 201-212-8; (±)-Omeprazole; MFCD00083192; Omeprazole; 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulphinyl]-1H-benzimidazole; aulcer; 6-Methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole; 5-Methoxy-2-{[(4-methoxy-3,5-dimethyl-2-pyridinyl
Molecular FormulaC17H19N3O3S
Molecular Weight345.42
Purity98%
Density1.4±0.1 g/cm3
Boiling Point600.0±60.0 °C at 760 mmHg
Melting Point156ºC
AppearanceWhite crystalline solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 73590-58-6 |
| Catalog No. | 2A-9011769 |
| Chinese Name | 奥美拉唑 |
| Synonyms | 5-methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)-methylsulfinyl]benzimidazole; 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole; Omepral; (RS)-5-Methoxy-2-(4-methoxy-3,5-dimethyl-2-pyridylmethylsulphinyl)benzimidazole; elgam; ANTRA; MEPRAL; Zoltum; PRILOSEC; (-)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole; zimor; Losec; Omeprazen; Pepticum; prysma; 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole; EINECS 201-212-8; (±)-Omeprazole; MFCD00083192; Omeprazole; 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulphinyl]-1H-benzimidazole; aulcer; 6-Methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole; 5-Methoxy-2-{[(4-methoxy-3,5-dimethyl-2-pyridinyl |
| Molecular Formula | C17H19N3O3S |
| Molecular Weight | 345.42 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 600.0±60.0 °C at 760 mmHg |
| Melting Point | 156ºC |
| Appearance | White crystalline solid |
| Water Solubility | H2O: 0.5 mg/mL |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | Omeprazole (Prilosec) is a proton pump inhibitor that can treat indigestion. |
| PubChem ID | 329823089 |
| MDL Number | MFCD00083192 |
| SMILES | COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C |
| InChI | 1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20) |
| InChI Key | SUBDBMMJDZJVOS-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/11769_1_73590_58_6.pdf |
| Bioactivity | Omeprazole(Prilosec) is a proton pump inhibitor used in the treatment of dyspepsia.Target: Proton PumpOmeprazole is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger-Ellison syndrome. Omeprazole virtually eliminated intragastric acidity in all patients: the median 24 hour intragastric pH rose from 1.4 to 5.3 and the mean hourly hydrogen ion activity fell from 38.50 to 1.95 mmol(mEq)/1 (p less than 0.001). This inhibition of 24 hour intragastric acidity is more profound than that previously reported with either cimetidine 1 g daily or ranitidine 300 mg daily [1]. The pharmacokinetics of omeprazole were studied in a group of healthy male subjects after single and repeated oral doses of 30 and 60 mg. Absorption of omeprazole from its enteric-coated formulation was unpredictable. There was a highly significant increase in the area under the plasma concentration time curve (AUC) after repeated dosing. Omeprazole increases its own relative availability following repeated dosing. This may be due to inhibition of gastric acid secretion by omeprazole which is an acid-labile compound [2].Clinical indications: Duodenal ulcer; Endocrine tumor; Esophagitis; Gastroesophageal reflux; Helicobacter pylori infection; Stomach ulcer; Zollinger-Ellison syndromeToxicity: Symptoms of overdose include confusion, drowsiness, blurred vision, tachycardia, nausea, diaphoresis, flushing, headache, and dry mouth. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump Research Areas >> Metabolic Disease References [1]. Walt, R.P., et al., Effect of daily oral omeprazole on 24 hour intragastric acidity. Br Med J (Clin Res Ed), 1983. 287(6384): p. 12-4. [2]. Howden, C.W., et al., Oral pharmacokinetics of omeprazole. Eur J Clin Pharmacol, 1984. 26(5): p. 641-3. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 600.0±60.0 °C at 760 mmHg Melting Point 156ºC Molecular Formula C17H19N3O3S Molecular Weight 345.416 Flash Point 316.7±32.9 °C Exact Mass 345.114716 PSA 96.31000 LogP 2.17 Vapour Pressure 0.0±1.7 mmHg at 25°C Index of Refraction 1.669 InChIKey SUBDBMMJDZJVOS-UHFFFAOYSA-N SMILES COc1ccc2nc(S(=O)Cc3ncc(C)c(OC)c3C)[nH]c2c1 Storage condition 2-8°C Stability Stable, but hygroscopic and photosensitive. Incompatible with strong oxidizing agents. Store in the dark. Water Solubility H2O: 0.5 mg/mL |
| Use of | Properties Articles143 Name 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Synonym More Synonyms omeprazole Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump Research Areas >> Metabolic Disease References [1]. Walt, R.P., et al., Effect of daily oral omeprazole on 24 hour intragastric acidity. Br Med J (Clin Res Ed), 1983. 287(6384): p. 12-4. [2]. Howden, C.W., et al., Oral pharmacokinetics of omeprazole. Eur J Clin Pharmacol, 1984. 26(5): p. 641-3. Chemical & Physical Properties Molecular Formula C17H19N3O3S Exact Mass 345.114716 PSA 96.31000 Index of Refraction 1.669 InChIKey SUBDBMMJDZJVOS-UHFFFAOYSA-N Stability Stable, but hygroscopic and photosensitive. Incompatible with strong oxidizing agents. Store in the dark. |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1230 International Maritime Transport Danger Regulations: 1230 International Air Transport Danger Regulations: 1230 14.2 United Nations shipping name European Land Transport Dangerous Regulations: METHANOL, solution IMDG Code: METHANOL, solution IFRS: Methanol, solution 14.3 Transport hazard categories European land transport risk code: 3 (6.1) International sea transport risk code: 3 (6.1) International air transport risk code: 3 (6.1) 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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