CAS Number106730-54-5
Synonyms1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxonicotinonitrile; Olprinone [INN]; 1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile; 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile; UNII-4Y8BMI9YGC; Loprinone; Coretec; MFCD00868774; Olprinone; 1,2-dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile; 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile; Olprinone|
Molecular FormulaC14H10O1N4
Molecular Weight250.26
Purity98%
Density1.3±0.1 g/cm3
Melting Point>300ºC
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 106730-54-5 |
| Catalog No. | 2A-9011763 |
| Chinese Name | 奥普力农 |
| Synonyms | 1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxonicotinonitrile; Olprinone [INN]; 1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile; 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile; UNII-4Y8BMI9YGC; Loprinone; Coretec; MFCD00868774; Olprinone; 1,2-dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile; 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile; Olprinone| |
| Molecular Formula | C14H10O1N4 |
| Molecular Weight | 250.26 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Melting Point | >300ºC |
| Storage Condition | 2~8℃, dry, sealed |
| Packaging | II |
| Application | Olprinone (Loprinone) is a phosphodiesterase 3 (PDE3) inhibitor. |
| HTC | 29183000 |
| MDL Number | MFCD25541649 |
| SMILES | Cc1[nH]c(=O)c(C#N)cc1-c1ccc2nccn2c1 |
| InChI | InChI=1S/C14H10N4O/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10/h2-6,8H,1H3,(H,17,19) |
| InChI Key | JPAWFIIYTJQOKW-UHFFFAOYSA-N |
| Hazard Symbols | 8 |
| MSDS | msds/11763_1_106730_54_5.pdf |
| Use of | Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. IC50 value:Target: PDE3Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury. Properties Name 5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1H-pyridine-3-carbonitrile Synonym More Synonyms Olprinone Biological Activity Description Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. IC50 value:Target: PDE3Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Cardiovascular Disease References [1]. Tsubokawa T, Ishizuka S, Fukumoto K, et al. The effect of hemodilution by cardiopulmonary bypass on protein binding of olprinone. J Anesth. 2012 . [2]. Mokra D, Drgova A, Pullmann R Sr, et al. Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury. Pulm Pharmacol Ther. 2012 Jun;25(3):216-22. [3]. Yamanaka H, Hayashi Y, Kamibayashi T, Mashimo T. Effect of olprinone, a phosphodiesterase III inhibitor, on balance of cerebral oxygen supply and demand during cardiopulmonary bypass. J Cardiovasc Pharmacol. 2011 May;57(5):579-83. [4]. Mazzon E, Esposito E, Di Paola R, et al. Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice. Pharmacol Res. 2011 Jul;64(1):68-79. Chemical & Physical Properties Molecular Formula C14H10N4O Exact Mass 250.085464 PSA 73.95000 Index of Refraction 1.703 InChIKey JPAWFIIYTJQOKW-UHFFFAOYSA-N Safety Information Hazard Codes T,N,C WGK Germany 3 RTECS AK5110000 Packaging Group II Hazard Class 8 HS Code 29183000 Synthetic Route 4-(dimethylamin... CAS#:106730-70-5 2-Cyanoacetamide CAS#:107-91-5 CAS#:106730-54-5 Literature: Yamanaka; Miyake; Suda; Ohhara; Ogawa Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1556 - 1567 2-amino-5-bromo... CAS#:1072-97-5 CAS#:106730-54-5 Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567 Methyl 6-aminon... CAS#:36052-24-1 CAS#:106730-54-5 Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567 Precursor & DownStream Precursor 9 CAS#:106730-70-5 4-(dimethylamin... CAS#:107-91-5 2-Cyanoacetamide CAS#:1072-97-5 2-amino-5-bromo... CAS#:36052-24-1 Methyl 6-aminon... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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