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Olopatadine Hydrochloride structure, CAS 140462-76-6

Olopatadine Hydrochloride

CAS Number140462-76-6

SynonymsAL 4943A; MFCD00875716; Olopatadine hydrochloride; {(11Z)-11-[3-(Dimethylamino)propyliden]-6,11-dihydrodibenzo[b,e]oxepin-2-yl}essigsäurehydrochlorid; Olopatadine (hydrochloride)

Molecular FormulaC21H24ClNO3

Molecular Weight373.87

Purity98%

Density1.221 g/cm3

Boiling Point523ºC at 760mmHg

Melting Point242-245ºC

Flash Point

Appearancewhite solid

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Cat. No.: 2A-9011761 Purity: 98%
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Quality Control of [ 140462-76-6 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number140462-76-6
Catalog No.2A-9011761
Chinese Name盐酸奥洛他定
SynonymsAL 4943A; MFCD00875716; Olopatadine hydrochloride; {(11Z)-11-[3-(Dimethylamino)propyliden]-6,11-dihydrodibenzo[b,e]oxepin-2-yl}essigsäurehydrochlorid; Olopatadine (hydrochloride)
Molecular FormulaC21H24ClNO3
Molecular Weight373.87
Purity98
Density1.221 g/cm3
Boiling Point523ºC at 760mmHg
Melting Point242-245ºC
Appearancewhite solid
Storage ConditionRefrigerator
ApplicationOlopatadine hydrochloride is a histamine receptor blocker that can act on allergic conjunctivitis.
HTC2932999099
PubChem ID329750608
MDL NumberMFCD00875716
SMILESCl.CN(C)CC\C=C1\c2ccccc2COc3ccc(CC(O)=O)cc13
InChI1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;
InChI KeyHVRLZEKDTUEKQH-NOILCQHBSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard SymbolsTransport
MSDSmsds/11761_1_140462_76_6.pdf
BioactivityOlopatadine HCl is a histamine blocker used to treat allergic conjunctivitis.Target: Histamine ReceptorOlopatadine is one of the second-generation histamine H1 receptor antagonists that are treated for allergic disorders. Olopatadine significantly inhibited the ear swelling and the increased production of IL-4, IL-1beta, IL-6, GM-CSF and NGF in the lesioned ear [1]. Olopatadine was highly and rapidly absorbed in healthy human volunteers. The urinary excretion of olopatadine accounted for not less than 58% and the contribution of metabolism was considerably low in the clearance of olopatadine in humans. Olopatadine is one of the few renal clearance drugs in antiallergic drugs. Olopatadine was shown to be useful for the treatment of allergic rhinitis and chronic urticaria in double-blind clinical trials [2]. AL-4943A inhibits histamine release in a concentration-dependent fashion (IC50 = 559 microM) from human conjunctival mast cell preparations in vitro. Passive anaphylaxis in guinea pig conjunctiva was attenuated by AL-4943A applied 30 min prior to intravenous or topical ocular antigen challenge (ED50 values 0.0067% and 0.0170%, w/v, respectively) [3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. Tamura, T., et al., Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice. Pharmacology, 2005. 75(1): p. 45-52. [2]. Ohmori, K., et al., Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antiallergic drug. Jpn J Pharmacol, 2002. 88(4): p. 379-97. [3]. Yanni, J.M., et al., The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent. J Ocul Pharmacol Ther, 1996. 12(4): p. 389-400. Chemical & Physical Properties Density 1.221 g/cm3 Boiling Point 523ºC at 760mmHg Melting Point 242-245ºC Molecular Formula C21H24ClNO3 Molecular Weight 373.873 Flash Point 270.1ºC Exact Mass 373.144470 PSA 49.77000 LogP 4.39150 Vapour Pressure 9.65E-13mmHg at 25°C InChIKey HVRLZEKDTUEKQH-NOILCQHBSA-N SMILES CN(C)CCC=C1c2ccccc2COc2ccc(CC(=O)O)cc21.Cl Storage condition Refrigerator
Use ofProperties Articles35 Name Olopatadine Hydrochloride Synonym More Synonyms Olopatadine Hydrochloride Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. Tamura, T., et al., Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice. Pharmacology, 2005. 75(1): p. 45-52. [2]. Ohmori, K., et al., Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antiallergic drug. Jpn J Pharmacol, 2002. 88(4): p. 379-97. [3]. Yanni, J.M., et al., The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent. J Ocul Pharmacol Ther, 1996. 12(4): p. 389-400. Chemical & Physical Properties Exact Mass 373.144470 PSA 49.77000 LogP 4.39150 InChIKey HVRLZEKDTUEKQH-NOILCQHBSA-N Storage condition Refrigerator
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 0.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European land transport hazard regulations: TOXIC SOLID, ORGANIC, N.O.S. International Maritime Hazardous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (OLOPATADINE HYDROCHLORIDE) International air transport hazard regulations: Toxic solid, organic, n.o.s. (OLOPATADINE HYDROCHLORIDE) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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