CAS Number1404-19-9
SynonymsOligomycin From Streptomyces Diastatochromogenes; EINECS 215-767-9; MFCD00065705
Molecular FormulaC135H220O33
Molecular Weight791.06
Purity≥90 (mixture of A, B, and C isomers, HPLC)%
Density1.14 g/cm3
Boiling Point886.3ºC at 760 mmHg
Melting Point84-100ºC
Appearancepowder
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1404-19-9 |
| Catalog No. | 2A-9011755 |
| Chinese Name | 寡霉素 |
| Synonyms | Oligomycin From Streptomyces Diastatochromogenes; EINECS 215-767-9; MFCD00065705 |
| Molecular Formula | C135H220O33 |
| Molecular Weight | 791.06 |
| Purity | ≥90 (mixture of A, B, and C isomers, HPLC) |
| Density | 1.14 g/cm3 |
| Boiling Point | 886.3ºC at 760 mmHg |
| Melting Point | 84-100ºC |
| Appearance | powder |
| Water Solubility | Sparingly soluble in water. Soluble in DMSO (20mg/ |
| Storage Condition | Sealed, stored at -20ºC |
| Packaging | III |
| Application | Oligomycins are macrolides produced by Streptomyces and are toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthase. Mitochondrial F1FO-ATP synthase can be |
| MDL Number | MFCD01779388 |
| SMILES | CCC\1CCC2OC3(CCC(C)C(CC(C)O)O3)C(C)C(OC(=O)\C=C\C(C)C(O)C(C)C(=O)C(C)C(O)C(C)C(=O)C(C)(O)C(O)C(C)C\C=C\C=C1)C2C |
| InChI | 1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15-,21-18+ |
| InChI Key | MNULEGDCPYONBU-ZUSSGZTJSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/11755_1_1404_19_9.pdf |
| Bioactivity | Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases. The mitochondrial F1FO ATP synthase can switch to an ATP hydrolase during ischemia, so that, under these conditions, inhibition by oligomycins will reduce ATP depletion rather than block ATP synthesis. Related Catalog Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Membrane Transporter/Ion Channel >> ATP Synthase Chemical & Physical Properties Density 1.14 g/cm3 Boiling Point 886.3ºC at 760 mmHg Melting Point 84-100ºC Molecular Formula C135H220O33 Molecular Weight 2371.171 Flash Point 252ºC Exact Mass 2369.553711 PSA 536.99000 LogP 17.71190 Vapour Pressure 0mmHg at 25°C Index of Refraction 1.543 Storage condition −20°C Water Solubility Sparingly soluble in water. Soluble in DMSO (20mg/ml) and ethanol (30mg/ml) /n |
| Use of | Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases. The mitochondrial F1FO ATP synthase can switch to an ATP hydrolase during ischemia, so that, under these conditions, inhibition by oligomycins will reduce ATP depletion rather than block ATP synthesis. Properties Name Oligomycin Synonym More Synonyms Oligomycin Biological Activity Description Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases. The mitochondrial F1FO ATP synthase can switch to an ATP hydrolase during ischemia, so that, under these conditions, inhibition by oligomycins will reduce ATP depletion rather than block ATP synthesis. Related Catalog Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Membrane Transporter/Ion Channel >> ATP Synthase Chemical & Physical Properties Molecular Formula C135H220O33 Exact Mass 2369.553711 PSA 536.99000 LogP 17.71190 Index of Refraction 1.543 |
| Transport Info | Product Name: Oligomycin |
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