CAS Number991-42-4
SynonymsMcneil 1025; NORBORMIDE; Nobormide; Shoxin; Caswell No. 606; Raticate; 5-(α-hydroxy-α-2-pyridylbenzyl)-7-(α-2-pyridylbenzylidene)bicyclo[2.2.1]hept-5-ene-2,3-dicarboximide; 5-(α-hydroxy-α-2-pyridylbenzyl)-7-(α-2-pyridylbenzylidene)-8,9,10-trinorborn-5-ene-2,3-dicarboximide; EINECS 213-589-6
Molecular FormulaC33H25N3O3
Molecular Weight511.57
Purity98%
Density1.346g/cm3
Boiling Point780.539ºC at 760 mmHg
Melting Point190-198ºC
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 991-42-4 |
| Catalog No. | 2A-9011700 |
| Chinese Name | 鼠特灵 |
| Synonyms | Mcneil 1025; NORBORMIDE; Nobormide; Shoxin; Caswell No. 606; Raticate; 5-(α-hydroxy-α-2-pyridylbenzyl)-7-(α-2-pyridylbenzylidene)bicyclo[2.2.1]hept-5-ene-2,3-dicarboximide; 5-(α-hydroxy-α-2-pyridylbenzyl)-7-(α-2-pyridylbenzylidene)-8,9,10-trinorborn-5-ene-2,3-dicarboximide; EINECS 213-589-6 |
| Molecular Formula | C33H25N3O3 |
| Molecular Weight | 511.57 |
| Purity | 98 |
| Density | 1.346g/cm3 |
| Boiling Point | 780.539ºC at 760 mmHg |
| Melting Point | 190-198ºC |
| Storage Condition | The warehouse is ventilated and dried at low tempe |
| Packaging | I |
| Application | Norbormide exhibits vasoconstrictive activity by blocking calcium ion channels. Norbormide's activity is species- and tissue-specific, endothelium-independent, and restricted to peripheral arteries in |
| SMILES | O=C1NC(=O)C2C3C(C(O)(c4ccccc4)c4ccccn4)=CC(C3=C(c3ccccc3)c3ccccn3)C12 |
| InChI | InChI=1S/C33H25N3O3.ClH/c37-31-28-22-19-23(33(39,21-13-5-2-6-14-21)25-16-8-10-18-35-25)29(30(28)32(38)36-31)27(22)26(20-11-3-1-4-12-20)24-15-7-9-17-34-24;/h1-19,22,28-30,39H,(H,36,37,38);1H/b27-26-; |
| InChI Key | DNTHHIVFNQZZRD-CYYJNZCTSA-N |
| Hazard Symbols | 6.1(a) |
| Bioactivity | Norbormide shows vasoconstrictor activity by blocking calcium channel. The activity of Norbormide is species- and tissue-specific, endothelium independent, and is restricted to the peripheral arteries of rat. Norbormide is also a toxicant, and the oral LD50s in mouse, hamster, guinea pig and rabbit are 2250, 140, 620, and 1000 mg/kg[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [1]. Bova S, et al. Norbormide: a calcium entry blocker with selective vasoconstrictor activity in rat peripheral arteries. Cardiovasc Drug Rev. 2001 Fall;19(3):226-33. Chemical & Physical Properties Density 1.346g/cm3 Boiling Point 780.539ºC at 760 mmHg Melting Point 190-198ºC Molecular Formula C33H25N3O3 Molecular Weight 511.57 Flash Point >230 °F Exact Mass 511.19000 PSA 92.18000 LogP 4.61820 Index of Refraction 1.69 InChIKey DNTHHIVFNQZZRD-CYYJNZCTSA-N SMILES O=C1NC(=O)C2C3C(C(O)(c4ccccc4)c4ccccn4)=CC(C3=C(c3ccccc3)c3ccccn3)C12 |
| Use of | Properties Name norbormide Synonym More Synonyms Norbormide Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [1]. Bova S, et al. Norbormide: a calcium entry blocker with selective vasoconstrictor activity in rat peripheral arteries. Cardiovasc Drug Rev. 2001 Fall;19(3):226-33. Chemical & Physical Properties Molecular Formula C33H25N3O3 Exact Mass 511.19000 PSA 92.18000 LogP 4.61820 Index of Refraction 1.69 InChIKey DNTHHIVFNQZZRD-CYYJNZCTSA-N |
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