CAS Number54527-84-3
SynonymsUNII:K5BC5011K3; dafil; EINECS 259-198-4; MFCD00057327; Barizin; Cardene; Nicardipine HCl; lincil; loxen; Aprovan; dagan; NICODEL; Dacarel; YC-93; Nicardipine Hydrochloride; Vasonas; Nicardipine (Hydrochloride)
Molecular FormulaC26H30ClN3O6
Molecular Weight515.99
Purity≥98%
Boiling Point603.4ºC at 760 mmHg
Melting Point176-1780C
Appearancepowder
EINECS259-198-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 54527-84-3 |
| Catalog No. | 2A-0201798 |
| Chinese Name | 盐酸尼卡地平 |
| Synonyms | UNII:K5BC5011K3; dafil; EINECS 259-198-4; MFCD00057327; Barizin; Cardene; Nicardipine HCl; lincil; loxen; Aprovan; dagan; NICODEL; Dacarel; YC-93; Nicardipine Hydrochloride; Vasonas; Nicardipine (Hydrochloride) |
| Molecular Formula | C26H30ClN3O6 |
| Molecular Weight | 515.99 |
| Purity | ≥98 |
| Boiling Point | 603.4ºC at 760 mmHg |
| Melting Point | 176-1780C |
| Appearance | powder |
| Water Solubility | DMSO: ~1 mg/mL |
| Storage Condition | Sealed, stored at 2ºC -8ºC |
| Packaging | III |
| Application | Nicardipine (YC-93) hydrochloride is a calcium channel antagonist that has been widely used to control severe hypertension and other diseases, ischemic stroke, brain trauma, cerebral hemorrhage, etc. |
| EINECS | 259-198-4 |
| PubChem ID | 24277856 |
| MDL Number | MFCD00057327 |
| SMILES | Cl[H].COC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OCCN(C)Cc3ccccc3 |
| InChI | 1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H |
| InChI Key | AIKVCUNQWYTVTO-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/11631_1_54527_84_3.pdf |
| Bioactivity | Nicardipine Hcl(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease References [1]. Huang BR, et al. Anti-neuroinflammatory effects of the calcium channel blocker nicardipine on microglial cells: implications for neuroprotection. PLoS One. 2014 Mar 12;9(3):e91167. [2]. Amenta F, et al. Vascular and neuronal hypertensive brain damage: protective effect of treatment with nicardipine. J Hypertens Suppl. 1996 Oct;14(3):S29-35. [3]. Gasior M, et al. Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice. J Neural Transm. 1996;103(7):819-31. Chemical & Physical Properties Boiling Point 603.4ºC at 760 mmHg Melting Point 176-1780C Molecular Formula C26H30ClN3O6 Molecular Weight 515.986 Flash Point 318.7ºC Exact Mass 515.182312 PSA 113.69000 LogP 5.33180 Storage condition 2-8°C Water Solubility DMSO: ~1 mg/mL |
| Use of | Nicardipine Hcl(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage. Properties Articles13 Name Nicardipine hydrochloride Synonym More Synonyms Nicardipine Hydrochloride Biological Activity Description Nicardipine Hcl(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease References [1]. Huang BR, et al. Anti-neuroinflammatory effects of the calcium channel blocker nicardipine on microglial cells: implications for neuroprotection. PLoS One. 2014 Mar 12;9(3):e91167. [2]. Amenta F, et al. Vascular and neuronal hypertensive brain damage: protective effect of treatment with nicardipine. J Hypertens Suppl. 1996 Oct;14(3):S29-35. [3]. Gasior M, et al. Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice. J Neural Transm. 1996;103(7):819-31. Chemical & Physical Properties Exact Mass 515.182312 PSA 113.69000 LogP 5.33180 |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (2-(Benzylmethylamino)ethyl methyl 1,4-dihydro-2,6- dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylatemonohydrochloride) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (2-(Benzylmethylamino)ethyl methyl 1,4-dihydro-2,6- dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylatemonohydrochloride) International air transport hazard regulations: Toxic solid, organic, n.o.s. (2-(Benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl)pyridine-3,5-dicarboxylatemonohydrochloride) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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