EN
0
Home > Products > Pharmaceuticals & Life Science > API & Advanced Intermediates > Nelfinavir mesylate
Nelfinavir mesylate structure, CAS 159989-65-8

Nelfinavir mesylate

CAS Number159989-65-8

SynonymsNelfinavir mesylate; MFCD00931436; Nelfinavir mesylate hydrate; AZT/3TC/NLFR combination; Nelfinavir (Mesylate)

Molecular FormulaC33H49N3O7S2

Molecular Weight663.888

Purity98%

Density

Boiling Point786.8ºC at 760 mmHg

Melting Point131-135ºC

Flash Point

AppearanceA white or almost white powder

EINECS

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9011604 Purity: 98%
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 159989-65-8 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number159989-65-8
Catalog No.2A-9011604
Chinese Name甲磺酸奈非那韦
SynonymsNelfinavir mesylate; MFCD00931436; Nelfinavir mesylate hydrate; AZT/3TC/NLFR combination; Nelfinavir (Mesylate)
Molecular FormulaC33H49N3O7S2
Molecular Weight663.888
Purity98
Boiling Point786.8ºC at 760 mmHg
Melting Point131-135ºC
AppearanceA white or almost white powder
Storage ConditionStore at +4°C
ApplicationNelfinavir (AG-1341) is an oral human HIV-1 protease inhibitor with a Ki of 2nM.
SMILESCS(=O)(=O)O.Cc1c(O)cccc1C(=O)NC(CSc1ccccc1)C(O)CN1CC2CCCCC2CC1C(=O)NC(C)(C)C
InChIInChI=1S/C32H45N3O4S.CH4O3S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4;1-5(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,38)(H,34,39);1H3,(H,2,3,4)/t22-,23+,26-,27-,29+;/m0./s1
InChI KeyNQHXCOAXSHGTIA-SKXNDZRYSA-N
Hazard SymbolsTransport
MSDSmsds/11604_2_159989_65_8.pdf
BioactivityNelfinavir(AG-1341) is a potent and orally bioavailable human immunodeficiency virus HIV-1 protease inhibitor (Ki=2 nM) and is widely prescribed in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection. IC50 Valur: 2 nM (Ki for HIV-1 protease) [2]Target: HIV Proteasein vitro: In vitro exposure (72 hours) of HAECs to NEL (0.25-2 μg/mL) decreased both basal (2.5-fold) and insulin-induced NO production (4- to 5-fold). NEL suppressed insulin-induced phosphorylation of both Akt and eNOS at serine residues 473 and 1177, respectively. NEL decreased tyrosine phosphorylation of IR-β, IRS-1, and PI3K. Coexposure to troglitazone (TRO; 250 nM) ameliorated the suppressive effects of NEL on insulin signaling and NO production. Coexposure to TRO also increased eNOS expression in NEL-treated HAECs [1]. AG1343 is a potent enzyme inhibitor (Ki = 2 nM) and antiviral agent (HIV-1 ED50 = 14 nM). An X-ray cocrystal structure of the enzyme-AG1343 complex reveals how the novel thiophenyl ether and phenol-amide substituents of the inhibitor interact with the S1 and S2 subsites of HIV-1 protease, respectively [2].in vivo: In vivo studies indicate that AG1343 is well absorbed orally in a variety of species and possesses favorable pharmacokinetic properties in humans [2]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection References [1]. Mondal D, et al. Nelfinavir suppresses insulin signaling and nitric oxide production by human aortic endothelial cells: protective effects of thiazolidinediones. Ochsner J. 2013 Spring;13(1):76-90. [2]. Kaldor SW, et al. Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease. J Med Chem. 1997 Nov 21;40(24):3979-85. Chemical & Physical Properties Boiling Point 786.8ºC at 760 mmHg Melting Point 131-135ºC Molecular Formula C33H49N3O7S2 Molecular Weight 663.888 Flash Point 429.7ºC Exact Mass 663.301208 PSA 189.95000 LogP 6.05210 InChIKey NQHXCOAXSHGTIA-SKXNDZRYSA-N SMILES CS(=O)(=O)O.Cc1c(O)cccc1C(=O)NC(CSc1ccccc1)C(O)CN1CC2CCCCC2CC1C(=O)NC(C)(C)C Storage condition Store at +4°C
Use ofProperties Name nelfinavir mesylate Synonym More Synonyms Nelfinavir mesylate Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection References [1]. Mondal D, et al. Nelfinavir suppresses insulin signaling and nitric oxide production by human aortic endothelial cells: protective effects of thiazolidinediones. Ochsner J. 2013 Spring;13(1):76-90. [2]. Kaldor SW, et al. Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease. J Med Chem. 1997 Nov 21;40(24):3979-85. Chemical & Physical Properties Molecular Formula C33H49N3O7S2 Exact Mass 663.301208 PSA 189.95000 LogP 6.05210 InChIKey NQHXCOAXSHGTIA-SKXNDZRYSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
Related Products in API & Advanced Intermediates
Nandrolone laurate26490-31-32A-9011571
Nandrolone undecylate862-89-52A-9011572
Naproxen26159-31-92A-9011577
Naproxen sodium26159-34-22A-9011578
Nebivolol99200-09-62A-9011592
Nelfinavir mesylate159989-64-72A-9011605
Nevirapine129618-40-22A-9011622
Nifedipine21829-25-42A-9011652
Nimodipine66085-59-42A-9011671
Noctone; Ranitidine Hydrochloride71130-06-82A-9011688
Browse all API & Advanced Intermediates products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA