CAS Number26159-34-2
SynonymsEINECS 247-486-2; sodium (S)-2-(6-methoxynaphthalen-2-yl)propanoate; Anaprox,Naprelan; (S)-Naproxen Sodium Salt; Naproxen sodium; MFCD00058507; Naproxen (sodium)
Molecular FormulaC14H13NaO3
Molecular Weight252.24
Purity98.0-102.0%
Boiling Point403.9ºC at 760 mmHg
Melting Point250-251ºC
Appearancepowder
EINECS247-486-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 26159-34-2 |
| Catalog No. | 2A-9011578 |
| Chinese Name | 萘普生钠 |
| Synonyms | EINECS 247-486-2; sodium (S)-2-(6-methoxynaphthalen-2-yl)propanoate; Anaprox,Naprelan; (S)-Naproxen Sodium Salt; Naproxen sodium; MFCD00058507; Naproxen (sodium) |
| Molecular Formula | C14H13NaO3 |
| Molecular Weight | 252.24 |
| Purity | 98.0-102.0 |
| Boiling Point | 403.9ºC at 760 mmHg |
| Melting Point | 250-251ºC |
| Appearance | powder |
| Storage Condition | Desiccate at RT |
| Packaging | III |
| Application | Naproxen sodium is an inhibitor of COX-1 and COX-2, with IC50 values of 8.72 and 5.15 μM respectively in cell assays. |
| EINECS | 247-486-2 |
| HTC | 2918990090 |
| PubChem ID | 57654352 |
| MDL Number | MFCD00058507 |
| SMILES | [Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O |
| InChI | 1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1 |
| InChI Key | CDBRNDSHEYLDJV-FVGYRXGTSA-M |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/11578_1_26159_34_2.pdf |
| Bioactivity | Naproxen sodium is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology Target COX-2:5.65 μM (IC50, in intact cells ) COX-1:9.55 μM (IC50, in intact cells ) In Vitro Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively[1]. In Vivo Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation[2]. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM)[3]. Cell Assay BAEC are incubated for 30 min with Naproxen (0.1 ng/mL to 1 mg/mL). Arachidonic acid (30 μM) is then added, and the cells are incubated for a further 15 min at 37°C. The medium is then removed, and radioimmunoassay is used to measure the formation of 6-keto-PGF,a, PGE2, thromboxane B2, or PGF2a[1]. Animal Admin Rats[3] To measure the analgesic effects of naproxen in a carrageenaninduced model of monoarthritis, Male Sprague-Dawley rats (n=48, 217±28 g) are randomly divided into four groups of 12 by an internally developed computer program, allowing the blind performance of the behavioral experiment. To induce hyperalgesia by inflammation, animals in groups 1B, 1C, and 1D receive a 40-μL intra-articular injection of a saline solution containing 7.5 mg/mL carrageenan in the left hind limb under isoflurane anesthesia (time=−1 h). Animals in group 1A receive no injection. After 1 h (time=0) the animals in groups 1A, 1B, 1C, and 1D receive oral doses of naproxen in saline of 0, 0, 7.5 and 30 μmol/kg, respectively. The doses and time points of measurements are selected on the basis of simulations predicting measuring a full concentration-effect relationship within the time-span of the experiment[3]. Mice[2] Bleomycin (0.05 IU) is instilled intratracheally to C57BL/6 mice, which are then treated by micro-osmotic pump with vehicle, JNJ7777120 (40 mg/kg b.wt.), naproxen (21 mg/kg b.wt.), or a combination of both. Airway resistance to inflation, an index of lung stiffness, is assessed, and lung specimens are processed for inflammation, oxidative stress, and fibrosis markers[2]. References [1]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. [2]. Rosa AC, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351(2):308-16. [3]. Krekels EH, et al. Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain, fever, and the ex vivo synthesis of TXB2 and PGE2 in rats. Chemical & Physical Properties Boiling Point 403.9ºC at 760 mmHg Melting Point 250-251ºC Molecular Formula C14H13NaO3 Molecular Weight 252.241 Flash Point 154.5ºC Exact Mass 252.076233 PSA 49.36000 LogP 1.70180 Vapour Pressure 3.01E-07mmHg at 25°C InChIKey CDBRNDSHEYLDJV-FVGYRXGTSA-M SMILES COc1ccc2cc(C(C)C(=O)[O-])ccc2c1.[Na+] Storage condition Desiccate at RT |
| Use of | Naproxen sodium is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Properties Articles13 Name naproxen sodium Synonym More Synonyms naproxen sodium Biological Activity Description Naproxen sodium is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology COX-2:5.65 μM (IC50, in intact cells ) COX-1:9.55 μM (IC50, in intact cells ) In Vitro Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively[1]. References [1]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. [2]. Rosa AC, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351(2):308-16. [3]. Krekels EH, et al. Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain, fever, and the ex vivo synthesis of TXB2 and PGE2 in rats. Chemical & Physical Properties Molecular Formula C14H13NaO3 Exact Mass 252.076233 PSA 49.36000 LogP 1.70180 InChIKey CDBRNDSHEYLDJV-FVGYRXGTSA-M Storage condition Desiccate at RT |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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