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Nafamostat mesylate structure, CAS 82956-11-4

Nafamostat mesylate

CAS Number82956-11-4

SynonymsNAFAMOSTAT, MESYLATE; Nafamostatmesylate; MFCD00941430; Nafamostat mesilate; 6-Amidino-2-naphthyl 4-guanidino-benzoate dimethanesulphonate; Nafamostat . mesylate; 6-carbamimidoylnaphthalen-2-yl 4-carbamimidamidobenzoate methanesulfonate (1:1); NAFAMOSTAT MESYLATE; mostat mesylate; 6-Carbamimidoyl-2-naphthyl 4-[(diaminomethylene)amino]benzoate methanesulfonate (1:1); 6-[amino(imino)methyl]-2-naphthyl 4-{[amino(imino)methyl]amino}benzoate dimethanesulfonate; Nafamostat (mesylate); NAFAMOSTATMESILATE

Molecular FormulaC21H25N5O8S2

Molecular Weight539.58

Purity98%

Density

Boiling Point637.2ºCat 760 mmHg

Melting Point259-261°C

Flash Point

AppearanceYellowish brown to light orange solid

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9011549 Purity: 98%
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Quality Control of [ 82956-11-4 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number82956-11-4
Catalog No.2A-9011549
Chinese Name甲磺酸萘莫司他
SynonymsNAFAMOSTAT, MESYLATE; Nafamostatmesylate; MFCD00941430; Nafamostat mesilate; 6-Amidino-2-naphthyl 4-guanidino-benzoate dimethanesulphonate; Nafamostat . mesylate; 6-carbamimidoylnaphthalen-2-yl 4-carbamimidamidobenzoate methanesulfonate (1:1); NAFAMOSTAT MESYLATE; mostat mesylate; 6-Carbamimidoyl-2-naphthyl 4-[(diaminomethylene)amino]benzoate methanesulfonate (1:1); 6-[amino(imino)methyl]-2-naphthyl 4-{[amino(imino)methyl]amino}benzoate dimethanesulfonate; Nafamostat (mesylate); NAFAMOSTATMESILATE
Molecular FormulaC21H25N5O8S2
Molecular Weight539.58
Purity98
Boiling Point637.2ºCat 760 mmHg
Melting Point259-261°C
AppearanceYellowish brown to light orange solid
Water SolubilityWater solubility: soluble; very slightly soluble:
Storage ConditionWarehouse Ventilation Low Temperature Drying
ApplicationNafamostat mesylate is a broad-spectrum serine protease inhibitor, angiotensin inhibitor, can inhibit blood coagulation, and is a potential complement inhibitor.
SMILESCS(=O)(=O)O.CS(=O)(=O)O.N=C(N)c1ccc2cc(OC(=O)c3ccc(N=C(N)N)cc3)ccc2c1
InChIInChI=1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);2*1H3,(H,2,3,4)
InChI KeySRXKIZXIRHMPFW-UHFFFAOYSA-N
MSDSmsds/11549_2_82956_11_4.pdf
BioactivityNafamostat mesylate, a synthetic serine protease inhibitor, is an anticoagulant.Target: Serine ProteaseTranilast (FUT-175) is an antiallergic drug for bronchial asthma. It has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. It has also been investigated for use as an antiproliferative drug on drug-eluting stents.A 20-40 mg/h dose of FUT-175 prolonged coagulation time sufficiently in the instrumental blood of the extracorporeal circuit but not in the systemic blood. Its anticoagulant activity decreased immediately after hemodialysis. Therefore, we could manage all patients without any bleeding trouble during hemodialysis with FUT-175 as an anticoagulant. Although there were side effects of FUT-175, such as nausea, vomiting, itching and eruption, they were not serious, and FUT-175 could be administered without interruption. FUT-175 seems to be useful as an anticoagulant during hemodialysis for patients susceptible to bleeding. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cardiovascular Disease References [1]. Ikehara S, et al. Effect of FUT-175, a new synthetic protease inhibitor, on the development of lupus nephritis in (NZB x NZW) F1 mice. Immunology. 1985 Aug;55(4):595-600. [2]. Pak K, et al. Effectiveness of FUT-175, protease inhibitor, as an anticoagulant to hemodialysis. Hinyokika Kiyo. 1988 Jun;34(6):1077-81. Chemical & Physical Properties Boiling Point 637.2ºCat 760 mmHg Melting Point 259-261°C Molecular Formula C21H25N5O8S2 Molecular Weight 539.58 Flash Point 339.1ºC PSA 200.82000 LogP 4.90630 InChIKey SRXKIZXIRHMPFW-UHFFFAOYSA-N SMILES CS(=O)(=O)O.CS(=O)(=O)O.N=C(N)c1ccc2cc(OC(=O)c3ccc(N=C(N)N)cc3)ccc2c1
Use ofProperties Name Nafamostat Mesylate Synonym More Synonyms Nafamostat mesylate Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cardiovascular Disease References [2]. Pak K, et al. Effectiveness of FUT-175, protease inhibitor, as an anticoagulant to hemodialysis. Hinyokika Kiyo. 1988 Jun;34(6):1077-81. Chemical & Physical Properties Molecular Formula C21H25N5O8S2 PSA 200.82000 LogP 4.90630 InChIKey SRXKIZXIRHMPFW-UHFFFAOYSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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