CAS Number3106-85-2
SynonymsN-Acetyl-L-aspartyl-L-glutamic acid; N-acetyl-1-aspartylglutamic acid; NAAGA; AC-ASP-GLU; SPAGLUMIC ACID; N-(N-Acetyl-L-a-aspartyl)-L-glutamic Acid; N-acetyl-L-aspartyl-L-glutamate; N-Acetyl-L-α-aspartyl-L-glutamic acid; isospaglumic acid; AC-ASP-GLU H2O; AC-ASP-GLU-OH; MFCD00076652; Tacrine hydrochloride; N-acetyl-aspartatylglutamate; N-(N-Acetyl-L-α-aspartyl)-L-glutamic acid; ACETYL-D-E; Naaxia; NAAG; N-Acetylaspartylglutamic acid; NAAG Spaglumic acid
Molecular FormulaC11H16N2O8
Molecular Weight304.25
Purity≥97 (TLC)%
Density1.5±0.1 g/cm3
Boiling Point769.5±60.0 °C at 760 mmHg
Appearancepowder or crystals
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 3106-85-2 |
| Catalog No. | 2A-9011543 |
| Chinese Name | 异冬谷酸 |
| Synonyms | N-Acetyl-L-aspartyl-L-glutamic acid; N-acetyl-1-aspartylglutamic acid; NAAGA; AC-ASP-GLU; SPAGLUMIC ACID; N-(N-Acetyl-L-a-aspartyl)-L-glutamic Acid; N-acetyl-L-aspartyl-L-glutamate; N-Acetyl-L-α-aspartyl-L-glutamic acid; isospaglumic acid; AC-ASP-GLU H2O; AC-ASP-GLU-OH; MFCD00076652; Tacrine hydrochloride; N-acetyl-aspartatylglutamate; N-(N-Acetyl-L-α-aspartyl)-L-glutamic acid; ACETYL-D-E; Naaxia; NAAG; N-Acetylaspartylglutamic acid; NAAG Spaglumic acid |
| Molecular Formula | C11H16N2O8 |
| Molecular Weight | 304.25 |
| Purity | ≥97 (TLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 769.5±60.0 °C at 760 mmHg |
| Appearance | powder or crystals |
| Water Solubility | H2O: 50 mg/mL |
| Storage Condition | Sealed in a cool, dry environment at -20 ºC |
| Application | Isospaglumic acid is a neuropeptide present in millimolar concentrations in the brain. |
| HTC | 2924199090 |
| PubChem ID | 24891036 |
| MDL Number | MFCD00076652 |
| SMILES | CC(=O)NC(CC(O)=O)C(=O)NC(CCC(O)=O)C(O)=O |
| InChI | 1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21) |
| InChI Key | OPVPGKGADVGKTG-UHFFFAOYSA-N |
| NACRES Code | NA.32 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| MSDS | msds/11543_1_3106_85_2.pdf |
| Bioactivity | Isospaglumic acid is a neuropeptide found in millimolar concentrations in brain. Related Catalog Natural Products >> Acids and Aldehydes Research Areas >> Neurological Disease Target Human Endogenous Metabolite In Vitro Isospaglumic acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. NAAG is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of NAAG and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders[1]. References [1]. Coyle JT. The nagging question of the function of N-acetylaspartylglutamate. Neurobiol Dis. 1997;4(3-4):231-8. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 769.5±60.0 °C at 760 mmHg Molecular Formula C11H16N2O8 Molecular Weight 304.253 Flash Point 419.1±32.9 °C Exact Mass 304.090668 PSA 170.10000 LogP -1.96 Vapour Pressure 0.0±5.7 mmHg at 25°C Index of Refraction 1.540 InChIKey OPVPGKGADVGKTG-BQBZGAKWSA-N SMILES CC(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)O Storage condition −20°C Water Solubility H2O: 50 mg/mL |
| Use of | Isospaglumic acid is a neuropeptide found in millimolar concentrations in brain. Properties Articles50 Name n-acetyl-asp-glu Synonym More Synonyms Spaglumic Acid Biological Activity Description Isospaglumic acid is a neuropeptide found in millimolar concentrations in brain. Related Catalog Natural Products >> Acids and Aldehydes Research Areas >> Neurological Disease Human Endogenous Metabolite In Vitro Isospaglumic acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. NAAG is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of NAAG and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders[1]. References [1]. Coyle JT. The nagging question of the function of N-acetylaspartylglutamate. Neurobiol Dis. 1997;4(3-4):231-8. Chemical & Physical Properties Molecular Formula C11H16N2O8 Exact Mass 304.090668 PSA 170.10000 LogP -1.96 Index of Refraction 1.540 InChIKey OPVPGKGADVGKTG-BQBZGAKWSA-N SMILES CC(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)O |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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