CAS Number124858-35-1
SynonymsNadiflox; Activon; Acuatim; Jinofloxacin; Nadifloxacin; Nadixa; Nadoxin; MFCD00865081
Molecular FormulaC19H21FN2O4
Molecular Weight360.38
Purity98%
Density1.5±0.1 g/cm3
Boiling Point624.9±55.0 °C at 760 mmHg
Melting Point245-247ºC (dec)
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 124858-35-1 |
| Catalog No. | 2A-9011545 |
| Chinese Name | 那氟沙星 |
| Synonyms | Nadiflox; Activon; Acuatim; Jinofloxacin; Nadifloxacin; Nadixa; Nadoxin; MFCD00865081 |
| Molecular Formula | C19H21FN2O4 |
| Molecular Weight | 360.38 |
| Purity | 98 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 624.9±55.0 °C at 760 mmHg |
| Melting Point | 245-247ºC (dec) |
| Appearance | solid |
| Storage Condition | -20?C Freezer |
| Application | Nadifloxacin (OPC7251) is a broad-spectrum fluoroquinolone antibiotic that is effective against acne vulgaris. |
| PubChem ID | 329794855 |
| MDL Number | MFCD00865081 |
| SMILES | FC1=C(N2CCC(O)CC2)C3=C4C(C(C(C(O)=O)=CN4C(C)CC3)=O)=C1 |
| InChI | 1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26) |
| InChI Key | JYJTVFIEFKZWCJ-UHFFFAOYSA-N |
| NACRES Code | NA.21 |
| UNSPSC | 12352200 |
| MSDS | msds/11545_1_124858_35_1.pdf |
| Bioactivity | Nadifloxacin(OPC7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris. Target: AntibacterialNadifloxacin is a potent, broad-spectrum, quinolone agent approved for topical use in acne vulgaris and skin infections. Nadifloxacin inhibits the enzyme DNA gyrase that is involved in bacterial DNA synthesis and replication, thus inhibiting the bacterial multiplication. In vitro studies of nadifloxacin show potent and broad-spectrum antibacterial activity against aerobic Gram-positive, Gram-negative and anaerobic bacteria. Additionally, studies also suggest that the effectiveness of nadifloxacin in inflammatory acne lesions may be attributed to its inhibitory effect on pro-inflammatory cytokines like interleukin (IL)-1α, IL-6, and IL-8 which also play an important role in acne pathogenesis [1, 2]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Inflammation/Immunology References [1]. Jacobs, M.R. and P.C. Appelbaum, Nadifloxacin: a quinolone for topical treatment of skin infections and potential for systemic use of its active isomer, WCK 771. Expert Opin Pharmacother, 2006. 7(14): p. 1957-66. [2]. Choudhury, S., et al., Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial. Indian J Pharmacol, 2011. 43(6): p. 628-31. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 624.9±55.0 °C at 760 mmHg Melting Point 245-247ºC (dec) Molecular Formula C19H21FN2O4 Molecular Weight 360.379 Flash Point 331.7±31.5 °C Exact Mass 360.148529 PSA 82.77000 LogP 1.95 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.669 InChIKey JYJTVFIEFKZWCJ-UHFFFAOYSA-N SMILES CC1CCc2c(N3CCC(O)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23 Storage condition -20?C Freezer |
| Use of | Nadifloxacin(OPC7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris. Target: AntibacterialNadifloxacin is a potent, broad-spectrum, quinolone agent approved for topical use in acne vulgaris and skin infections. Nadifloxacin inhibits the enzyme DNA gyrase that is involved in bacterial DNA synthesis and replication, thus inhibiting the bacterial multiplication. In vitro studies of nadifloxacin show potent and broad-spectrum antibacterial activity against aerobic Gram-positive, Gram-negative and anaerobic bacteria. Additionally, studies also suggest that the effectiveness of nadifloxacin in inflammatory acne lesions may be attributed to its inhibitory effect on pro-inflammatory cytokines like interleukin (IL)-1α, IL-6, and IL-8 which also play an important role in acne pathogenesis [1, 2]. Properties Name nadifloxacin Synonym More Synonyms Nadifloxacin Biological Activity Description Nadifloxacin(OPC7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris. Target: AntibacterialNadifloxacin is a potent, broad-spectrum, quinolone agent approved for topical use in acne vulgaris and skin infections. Nadifloxacin inhibits the enzyme DNA gyrase that is involved in bacterial DNA synthesis and replication, thus inhibiting the bacterial multiplication. In vitro studies of nadifloxacin show potent and broad-spectrum antibacterial activity against aerobic Gram-positive, Gram-negative and anaerobic bacteria. Additionally, studies also suggest that the effectiveness of nadifloxacin in inflammatory acne lesions may be attributed to its inhibitory effect on pro-inflammatory cytokines like interleukin (IL)-1α, IL-6, and IL-8 which also play an important role in acne pathogenesis [1, 2]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Inflammation/Immunology References [1]. Jacobs, M.R. and P.C. Appelbaum, Nadifloxacin: a quinolone for topical treatment of skin infections and potential for systemic use of its active isomer, WCK 771. Expert Opin Pharmacother, 2006. 7(14): p. 1957-66. [2]. Choudhury, S., et al., Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial. Indian J Pharmacol, 2011. 43(6): p. 628-31. Chemical & Physical Properties Molecular Formula C19H21FN2O4 Exact Mass 360.148529 PSA 82.77000 Index of Refraction 1.669 InChIKey JYJTVFIEFKZWCJ-UHFFFAOYSA-N Storage condition -20?C Freezer |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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