CAS Number145375-43-5
SynonymsMitiglinide; Unii-D86I0xlb13; (-)-(2S,3a,7a-cis)-α-Benzylhexahydro-γ-oxo-2-isoindolinebutyric acid; (2S)-2-Benzyl-4-((3a,7a-cis)-octahydro-2H-isoindol-2-yl)-4-oxobutanoic Acid; (-)-(2S,3a,7a-cis)-a-Benzylhexahydro-g-oxo-2-isoindolinebutyric Acid; (2S)-2-Benzyl-4-[(3aR,7aS)-octahydro-2H-isoindol-2-yl]-4-oxobutanoic acid
Molecular FormulaC38H48O6N2Ca1
Molecular Weight668.89
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point519.6±43.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 145375-43-5 |
| Catalog No. | 2A-9011467 |
| Chinese Name | 米格列奈 |
| Synonyms | Mitiglinide; Unii-D86I0xlb13; (-)-(2S,3a,7a-cis)-α-Benzylhexahydro-γ-oxo-2-isoindolinebutyric acid; (2S)-2-Benzyl-4-((3a,7a-cis)-octahydro-2H-isoindol-2-yl)-4-oxobutanoic Acid; (-)-(2S,3a,7a-cis)-a-Benzylhexahydro-g-oxo-2-isoindolinebutyric Acid; (2S)-2-Benzyl-4-[(3aR,7aS)-octahydro-2H-isoindol-2-yl]-4-oxobutanoic acid |
| Molecular Formula | C38H48O6N2Ca1 |
| Molecular Weight | 668.89 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 519.6±43.0 °C at 760 mmHg |
| Application | Miteglinide (KAD-1229) is an insulinotropic drug and an ATP-sensitive potassium ion (KATP) channel antagonist. Miteglinide is highly specific for the Kir6.2/SUR1 complex (pancreatic beta cell KATP cha |
| HTC | 2942000000 |
| MDL Number | MFCD09955408 |
| SMILES | O=C(O)C(CC(=O)N1CC2CCCCC2C1)Cc1ccccc1 |
| InChI | InChI=1S/C19H25NO3/c21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13H2,(H,22,23) |
| InChI Key | WPGGHFDDFPHPOB-BBWFWOEESA-N |
| MSDS | msds/11467_1_145375_43_5.pdf |
| Use of | Properties Name [2(S)-cis]-Octahydro-γ-oxo-α-(phenylmethyl)-2H-isoindole-2-butanoic acid Synonym More Synonyms Mitiglinide Biological Activity Related Catalog Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel KATP channel[1] References [1]. Y Sunaga, et al. The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide. Eur J Pharmacol. 2001 Nov 9;431(1):119-25. [2]. Kiyoshi Ichikawa, et al. Effect of KAD-1229, a novel hypoglycaemic agent, on plasma glucose levels after meal load in type 2 diabetic rats. Clin Exp Pharmacol Physiol. May-Jun 2002;29(5-6):423-7. Chemical & Physical Properties Molecular Formula C19H25NO3 Exact Mass 315.183441 PSA 57.61000 Index of Refraction 1.567 InChIKey WPGGHFDDFPHPOB-BBWFWOEESA-N Safety Information HS Code 2942000000 Synthetic Route (3aS,6R,7aS)-8,... 787635-24-9 Mitiglinide 145375-43-5 Literature: Helvetica Chimica Acta, , vol. 87, # 8 p. 1935 - 1939 Octahydro-isoin... Mitiglinide 145375-43-5 Literature: Synthetic Communications, , vol. 37, # 13 p. 2153 - 2157 204187-39-3 Mitiglinide 145375-43-5 Literature: Chemical and Pharmaceutical Bulletin, , vol. 46, # 2 p. 337 - 340 Precursor & DownStream Precursor 5 CAS#:787635-24-9 (3aS,6R,7aS)-8,... CAS#:1470-99-1 Octahydro-isoindole CAS#:1141896-00-5 (2S)-2-benzyl-1... CAS#:125702-11-6 (E)-benzylidene... DownStream 0 |
| Transport Info | Product name: Mitiglinide calcium |
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