CAS Number72432-03-2
SynonymsBAY m 1099; Miglitol; (2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(hydroxymethyl)piperidin-3,4,5-triol; Diastabol; (2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(hydroxymethyl)-3,4,5-piperidinetriol; EINECS 276-661-6; MFCD00867240; GLYSET; Plumarol; BAY-m-1099; Seibule; (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol; N-(2-Hydroxyethyl)moranoline; BAY 1099; (2R,3R,4R,5S)-1-(2-hydroxyéthyl)-2-(hydroxyméthyl)pipéridine-3,4,5-triol
Molecular FormulaC8H17NO5
Molecular Weight207.22
Purity≥98 (HPLC)%
Density1.5±0.1 g/cm3
Boiling Point453.7±45.0 °C at 760 mmHg
Melting Point142-147 °C
Appearancepowder
EINECS276-661-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 72432-03-2 |
| Catalog No. | 2A-9011445 |
| Chinese Name | 米各尼醇 |
| Synonyms | BAY m 1099; Miglitol; (2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(hydroxymethyl)piperidin-3,4,5-triol; Diastabol; (2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(hydroxymethyl)-3,4,5-piperidinetriol; EINECS 276-661-6; MFCD00867240; GLYSET; Plumarol; BAY-m-1099; Seibule; (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol; N-(2-Hydroxyethyl)moranoline; BAY 1099; (2R,3R,4R,5S)-1-(2-hydroxyéthyl)-2-(hydroxyméthyl)pipéridine-3,4,5-triol |
| Molecular Formula | C8H17NO5 |
| Molecular Weight | 207.22 |
| Purity | ≥98 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 453.7±45.0 °C at 760 mmHg |
| Melting Point | 142-147 °C |
| Appearance | powder |
| Water Solubility | Soluble |
| Storage Condition | -20°C Freezer |
| Application | Miglitol is an oral antidiabetic compound that inhibits the breakdown of glycoconjugates into glucose. |
| EINECS | 276-661-6 |
| SMILES | N1([C@@H]([C@H]([C@@H]([C@H](C1)O)O)O)CO)CCO |
| InChI | 1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1 |
| InChI Key | IBAQFPQHRJAVAV-ULAWRXDQSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352205 |
| Hazard Symbols | Transport |
| MSDS | msds/11445_1_72432_03_2.pdf |
| Bioactivity | Miglitol is an oral anti-diabetic drug that acts by inhibiting the ability of the patient to breakdown complex carbohydrates into glucose.Target: OthersMiglitol is an oral anti-diabetic drug that acts by inhibiting the ability of the patient to breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body. Miglitol inhibits glycoside hydrolase enzymes called alpha-glucosidases. Since miglitol works by preventing digestion of carbohydrates, it lowers the degree of postprandial hyperglycemia. It must be taken at the start of main meals to have maximal effect. Its effect will depend on the amount of non-monosaccharide carbohydrates in a person's diet. Dietary supplementation with miglitol from pre-onset stage in OLETF rats delays the onset and development of diabetes and preserves the insulin secretory function of pancreatic islets [1]. Miglitol was orally administered at 40 mg/100 g of high-fat diet containing 45% kcal as fat to 12-week-old rats for 29 days, and age-matched rats without the agent were used as the respective controls [2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Fukaya, N., et al., The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats. Eur J Pharmacol, 2009. 624(1-3): p. 51-7. [2]. Hirata, A., et al., Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats. Horm Metab Res, 2009. 41(3): p. 213-20. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 453.7±45.0 °C at 760 mmHg Melting Point 114ºC Molecular Formula C8H17NO5 Molecular Weight 207.224 Flash Point 284.3±27.4 °C Exact Mass 207.110672 PSA 104.39000 LogP -1.40 Vapour Pressure 0.0±2.5 mmHg at 25°C Index of Refraction 1.598 InChIKey IBAQFPQHRJAVAV-ULAWRXDQSA-N SMILES OCCN1CC(O)C(O)C(O)C1CO Storage condition -20°C Freezer Water Solubility Soluble |
| Use of | Properties Articles31 Name Miglitol Synonym More Synonyms Miglitol Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Fukaya, N., et al., The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats. Eur J Pharmacol, 2009. 624(1-3): p. 51-7. [2]. Hirata, A., et al., Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats. Horm Metab Res, 2009. 41(3): p. 213-20. Chemical & Physical Properties Molecular Formula C8H17NO5 Exact Mass 207.110672 PSA 104.39000 LogP -1.40 Index of Refraction 1.598 InChIKey IBAQFPQHRJAVAV-ULAWRXDQSA-N Water Solubility Soluble |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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