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Metoprolol tartrate structure, CAS 56392-17-7

Metoprolol tartrate

CAS Number56392-17-7

SynonymsMFCD00941460; EINECS 260-148-9

Molecular FormulaC17H28NO6

Molecular Weight342.41

Purity98%

Density

Boiling Point398.6ºC at 760 mmHg

Melting Point120ºC

Flash Point

Appearanceliquid

EINECS200-659-6

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9011414 Purity: 98%
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Quality Control of [ 56392-17-7 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number56392-17-7
Catalog No.2A-9011414
Chinese Name酒石酸美托洛尔
SynonymsMFCD00941460; EINECS 260-148-9
Molecular FormulaC17H28NO6
Molecular Weight342.41
Purity98
Boiling Point398.6ºC at 760 mmHg
Melting Point120ºC
Appearanceliquid
Storage ConditionKeep the receptacle sealed, stored in a cool, dry
ApplicationMetoprolol is a cardioselective beta1 adrenergic blocker.
EINECS200-659-6
PubChem ID329817863
MDL NumberMFCD23141017
SMILESCC(C)NCC(COC1=CC=C(CCOC)C=C1)O.CC(C)NCC(COC2=CC=C(CCOC)C=C2)O.OC(C(O)=O)C(C(O)=O)O
InChI1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)
InChI KeyYGULWPYYGQCFMP-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard SymbolsTransport
MSDSmsds/11414_1_56392_17_7.pdf
BioactivityMetoprolol is a cardioselective β1-adrenergic blocking agent.Target: β1- adrenergic ReceptorPatients took 50 mg metoprolol twice daily with weekly titration to response or 200 mg twice daily. beta(1)-adrenergic receptor polymorphisms are important determinants of antihypertensive response to metoprolol. In the future, codon 49 and 389 genotypes or beta(1)-adrenergic receptor haplotypes might be used to predict the diastolic blood pressure response to metoprolol in patients with hypertension [1]. Patients were studied at baseline and after each dose titration of metoprolol succinate (at 25, 50, 100, and 200 mg once/day) and immediate-release carvedilol (at 3.125, 6.25, 12.5, and 25 mg twice/day). As assessed by glucose AUC, there was no significant difference in the degree of beta(2)-blockade between metoprolol 200 mg and carvedilol 25 mg. In contrast to these data, the degree of beta(2)-blockade as assessed by potassium AUC was greater for carvedilol compared with metoprolol across all doses [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease References [1]. Johnson, J.A., et al., Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin Pharmacol Ther, 2003. 74(1): p. 44-52. [2]. Zebrack, J.S., et al., Beta-receptor selectivity of carvedilol and metoprolol succinate in patients with heart failure (SELECT trial): a randomized dose-ranging trial. Pharmacotherapy, 2009. 29(8): p. 883-90. Chemical & Physical Properties Boiling Point 398.6ºC at 760 mmHg Melting Point 120ºC Molecular Formula C17H28NO6 Molecular Weight 342.41 Flash Point 194.9ºC PSA 216.50000 LogP 1.88560 InChIKey YGULWPYYGQCFMP-UHFFFAOYSA-N SMILES COCCc1ccc(OCC(O)CNC(C)C)cc1.COCCc1ccc(OCC(O)CNC(C)C)cc1.O=C(O)C(O)C(O)C(=O)O Stability Stable. Incompatible with strong oxidizing agents.
Use ofProperties Articles79 Name rac Metoprolol Hemi (+)-Tartrate Synonym More Synonyms Metoprolol Tartrate Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease References [1]. Johnson, J.A., et al., Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin Pharmacol Ther, 2003. 74(1): p. 44-52. [2]. Zebrack, J.S., et al., Beta-receptor selectivity of carvedilol and metoprolol succinate in patients with heart failure (SELECT trial): a randomized dose-ranging trial. Pharmacotherapy, 2009. 29(8): p. 883-90. Chemical & Physical Properties Molecular Formula C17H28NO6 PSA 216.50000 LogP 1.88560 InChIKey YGULWPYYGQCFMP-UHFFFAOYSA-N Stability Stable. Incompatible with strong oxidizing agents.
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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