CAS Number54143-57-6
SynonymsAnnavar; 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide monohydrochloride; 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide monohydrochloride; Benzamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-, hydrochloride (1:1); 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride (1:1); Metoclopramide hydrochloride [USAN:JAN]; 4-Amino-5-chlor-N-[2-(diethylamino)ethyl]-2-methoxybenzolcarboxamidhydrochlorid; o-Anisamide, 4-amino-5-chloro-N-[2- (diethylamino)ethyl]-, monohydrochloride; GastreseL.A; 4-amino-5-chloro-N-[2-(diéthylamino)éthyl]-2-méthoxybenzamide chlorhydrate; Benzamide, 4-amino-5-chloro-N-[2- (diethylamino)ethyl]-2-methoxy-, monohydrochloride; 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-o-anisamide hydrochloride; MFCD00150634;
Molecular FormulaC14H25Cl2N3O3
Molecular Weight354.27
Purity98.00%
Boiling Point418.7ºC at 760mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 54143-57-6 |
| Catalog No. | 2A-9011410 |
| Chinese Name | 盐酸甲氧氯普胺 |
| Synonyms | Annavar; 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide monohydrochloride; 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide monohydrochloride; Benzamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-, hydrochloride (1:1); 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride (1:1); Metoclopramide hydrochloride [USAN:JAN]; 4-Amino-5-chlor-N-[2-(diethylamino)ethyl]-2-methoxybenzolcarboxamidhydrochlorid; o-Anisamide, 4-amino-5-chloro-N-[2- (diethylamino)ethyl]-, monohydrochloride; GastreseL.A; 4-amino-5-chloro-N-[2-(diéthylamino)éthyl]-2-méthoxybenzamide chlorhydrate; Benzamide, 4-amino-5-chloro-N-[2- (diethylamino)ethyl]-2-methoxy-, monohydrochloride; 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-o-anisamide hydrochloride; MFCD00150634; |
| Molecular Formula | C14H25Cl2N3O3 |
| Molecular Weight | 354.27 |
| Purity | 98.00 |
| Boiling Point | 418.7ºC at 760mmHg |
| Storage Condition | Room temperature, dry |
| Application | Metoclopramide hydrochloride hydrate is a dopamine receptor D2 antagonist. |
| MDL Number | MFCD00150634 |
| SMILES | [Cl-].Clc1c(cc(c(c1)C(=O)NCCN(CC)CC)OC)N.O.[H+] |
| InChI | 1S/C14H22ClN3O2.ClH.H2O/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H;1H2 |
| InChI Key | KJBLQGHJOCAOJP-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/11410_1_54143_57_6.pdf |
| Bioactivity | Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist that is used as an antiemetic.IC50 Value:Target: D2 ReceptorMetoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Endocrinology Chemical & Physical Properties Boiling Point 418.7ºC at 760mmHg Molecular Formula C14H25Cl2N3O3 Molecular Weight 354.27 Flash Point 207ºC PSA 67.59000 LogP 3.77650 InChIKey KJBLQGHJOCAOJP-UHFFFAOYSA-N SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC.Cl.O |
| Use of | Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist that is used as an antiemetic.IC50 Value:Target: D2 ReceptorMetoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist. Properties Articles32 Name metoclopramide hydrochloride Synonym More Synonyms metoclopramide hydrochloride Biological Activity Description Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist that is used as an antiemetic.IC50 Value:Target: D2 ReceptorMetoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Endocrinology Chemical & Physical Properties PSA 67.59000 LogP 3.77650 InChIKey KJBLQGHJOCAOJP-UHFFFAOYSA-N |
| Transport Info | Product Name: Metoclopramide Hydrochloride |
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