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Minocycline hydrochloride structure, CAS 13614-98-7

Minocycline hydrochloride

CAS Number13614-98-7

Synonyms7-Dimethylamino-6-demethyl-6-deoxytetracycline Monohydrochloride; Minocin; MINOCYCLINE HCL; Minocyn; Arestin; VECTRIN; EINECS 237-099-7; Dynacin; Klinomycin; MFCD00083669; MINOCYCLINE HYDROCHLORIDE; Minocycline (hydrochloride)

Molecular FormulaC23H28ClN3O7

Molecular Weight493.94

Purity98%

Density

Boiling Point659.4ºC at 760mmHg

Melting Point205-210° (dec)

Flash Point

Appearancepowder

EINECS237-099-7

MSDSChineseEnglish

Symbol6.1(b)

Signal WordWarning

Cat. No.: 2A-9011457 Purity: 98%
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Quality Control of [ 13614-98-7 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number13614-98-7
Catalog No.2A-9011457
Chinese Name盐酸米诺环素
Synonyms7-Dimethylamino-6-demethyl-6-deoxytetracycline Monohydrochloride; Minocin; MINOCYCLINE HCL; Minocyn; Arestin; VECTRIN; EINECS 237-099-7; Dynacin; Klinomycin; MFCD00083669; MINOCYCLINE HYDROCHLORIDE; Minocycline (hydrochloride)
Molecular FormulaC23H28ClN3O7
Molecular Weight493.94
Purity98
Boiling Point659.4ºC at 760mmHg
Melting Point205-210° (dec)
Appearancepowder
Water SolubilityWater solubility: slightly soluble; soluble in: di
Storage Condition2-8°C
PackagingIII
ApplicationMinocycline hydrochloride is a broad-spectrum tetracycline antibiotic that acts by binding to the bacterial 30S ribosomal subunit and inhibiting protein synthesis.
EINECS237-099-7
HTC2942000000
PubChem ID24278175
MDL NumberMFCD00083669
SMILESCl.CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)N(C)C
InChI1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
InChI KeyGLMUAFMGXXHGLU-VQAITOIOSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard Symbols6.1(b)
MSDSmsds/11457_1_13614_98_7.pdf
BioactivityMinocycline hydrochloride is a broad-spectrum tetracycline antibiotic, acting by binding to the bacterial 30S ribosomal subunit and inhibiting protein synthesis. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Hu X, Wu B, Wang X, et al. Minocycline attenuates ischemia-induced ventricular arrhythmias in rats. Eur J Pharmacol. 2011 Mar 11;654(3):274-9. [2]. Tao R, Kim SH, Honbo N, et al. Minocycline protects cardiac myocytes against simulated ischemia-reperfusion injury by inhibiting poly(ADP-ribose) polymerase-1. J Cardiovasc Pharmacol. 2010 Dec;56(6):659-68. doi: 10.1097/FJC.0b013e3181faeaf0. [3]. Padi SS, Kulkarni SK. Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms. Eur J Pharmacol. 2008 Dec 28;601(1-3):79-87. doi: 10.1016/j.ejphar.2008.10.018. [4]. Brundula V, Rewcastle NB, Metz LM, et al. Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis. Brain. 2002 Jun;125(Pt 6):1297-308. [5]. Tikka T, Fiebich BL, Goldsteins G, et al. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci. 2001 Apr 15;21(8):2580-8. Chemical & Physical Properties Boiling Point 659.4ºC at 760mmHg Melting Point 205-210° (dec) Molecular Formula C23H28ClN3O7 Molecular Weight 493.937 Flash Point 352.6ºC Exact Mass 493.161591 PSA 164.63000 LogP 1.68890 Vapour Pressure 6.33E-28mmHg at 25°C InChIKey WTJXVDPDEQKTCV-VQAITOIOSA-N SMILES CN(C)c1ccc(O)c2c1CC1CC3C(N(C)C)C(=O)C(C(N)=O)=C(O)C3(O)C(=O)C1=C2O.Cl Storage condition 2-8°C Stability Light Sensitive
Use ofMinocycline hydrochloride is a broad-spectrum tetracycline antibiotic, acting by binding to the bacterial 30S ribosomal subunit and inhibiting protein synthesis. Properties Articles96 Name minocycline hydrochloride Synonym More Synonyms Minocycline hydrochloride Biological Activity Description Minocycline hydrochloride is a broad-spectrum tetracycline antibiotic, acting by binding to the bacterial 30S ribosomal subunit and inhibiting protein synthesis. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Hu X, Wu B, Wang X, et al. Minocycline attenuates ischemia-induced ventricular arrhythmias in rats. Eur J Pharmacol. 2011 Mar 11;654(3):274-9. [4]. Brundula V, Rewcastle NB, Metz LM, et al. Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis. Brain. 2002 Jun;125(Pt 6):1297-308. [5]. Tikka T, Fiebich BL, Goldsteins G, et al. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci. 2001 Apr 15;21(8):2580-8. Chemical & Physical Properties Exact Mass 493.161591 PSA 164.63000 LogP 1.68890 InChIKey WTJXVDPDEQKTCV-VQAITOIOSA-N Stability Light Sensitive
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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