CAS Number21535-47-7
SynonymsTolvon; 2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride (1:1); EINECS 244-426-7; 1,2,3,4,10,14b-Hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride; Mianserin HCl; Bolvidon; Athymil; Dibenzo[c,f]pyrazino[1,2-a]azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, hydrochloride (1:1); MFCD00055072; Mianserin hydrochloride; Norval; 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine Hydrochloride; Tetramide; Mianserin (hydrochloride)
Molecular FormulaC18H21ClN2
Molecular Weight300.83
Purity98%
Density1.18 g/cm3
Boiling Point411.3ºC at 760 mmHg
Melting Point>230ºC (dec.)
AppearanceWhite film-coated flakes, may be white or off-white after film coating is removed
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 21535-47-7 |
| Catalog No. | 2A-9011433 |
| Chinese Name | 盐酸米安色林 |
| Synonyms | Tolvon; 2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride (1:1); EINECS 244-426-7; 1,2,3,4,10,14b-Hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride; Mianserin HCl; Bolvidon; Athymil; Dibenzo[c,f]pyrazino[1,2-a]azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, hydrochloride (1:1); MFCD00055072; Mianserin hydrochloride; Norval; 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine Hydrochloride; Tetramide; Mianserin (hydrochloride) |
| Molecular Formula | C18H21ClN2 |
| Molecular Weight | 300.83 |
| Purity | 98 |
| Density | 1.18 g/cm3 |
| Boiling Point | 411.3ºC at 760 mmHg |
| Melting Point | >230ºC (dec.) |
| Appearance | White film-coated flakes, may be white or off-white after film coating is removed |
| Water Solubility | H2O: 3.4 mg/mL |
| Storage Condition | 2-8℃ |
| Packaging | III |
| Application | Mianserin hydrochloride is an H1 receptor inverse agonist with antidepressant activity. |
| HTC | 2933990090 |
| PubChem ID | 329817919 |
| MDL Number | MFCD00055072 |
| SMILES | Cl.CN1CCN2C(C1)c3ccccc3Cc4ccccc24 |
| InChI | 1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H |
| InChI Key | YNPFMWCWRVTGKJ-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/11433_1_21535_47_7.pdf |
| Bioactivity | Mianserin hydrochloride is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.Target: H1 receptorMianserin is a psychoactive drug of the tetracyclic antidepressant (TeCA) therapeutic family. It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant, anxiolytic (anti-anxiety), hypnotic (sedating), antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating), and antihistamine effects. It is not approved for use in the US, but its analogue, mirtazapine, is. Mianserin was the first antidepressant to reach the UK market that was less dangerous than the tricyclic antidepressants in overdose.Mianserin is an antagonist/inverse agonist of the H1, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT6, 5-HT7, α1-adrenergic, and α2-adrenergic receptors, and also inhibits the reuptake of norepinephrine. As a high affinity H1 receptor inverse agonist, mianserin has strong antihistamine effects (sedation, weight gain, etc.). Contrarily, it has negligible affinity for the mACh receptors, and thus lacks any anticholinergic properties. It was recently found to be a potent kappa opioid receptor agonist. In addition, mianserin also appears to be a potent antagonist of the neuronal octopamine receptor. What implications this may have on mood are currently unknown, however octopamine has been implicated in the regulation of sleep, appetite and insulin production and therefore may theoretically contribute to the overall side effect profile of mianserin. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Natural Products >> Alkaloid Research Areas >> Neurological Disease References [1]. Olianas MC,et al. The atypical antidepressant mianserin exhibits agonist activity at κ-opioid receptors. Br J Pharmacol. 2012 Nov;167(6):1329-41. [2]. Roeder T. High-affinity antagonists of the locust neuronal octopamine receptor. Eur J Pharmacol. 1990 Nov 27;191(2):221-4. Chemical & Physical Properties Density 1.18 g/cm3 Boiling Point 411.3ºC at 760 mmHg Melting Point >230ºC (dec.) Molecular Formula C18H21ClN2 Molecular Weight 300.826 Flash Point 186.1ºC Exact Mass 300.139313 PSA 6.48000 LogP 3.88880 Vapour Pressure 5.65E-07mmHg at 25°C InChIKey YNPFMWCWRVTGKJ-UHFFFAOYSA-N SMILES CN1CCN2c3ccccc3Cc3ccccc3C2C1.Cl Water Solubility H2O: 3.4 mg/mL |
| Use of | Properties Articles58 Name Mianserin Hydrochloride Synonym More Synonyms Mianserin hydrochloride Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Natural Products >> Alkaloid Research Areas >> Neurological Disease References [1]. Olianas MC,et al. The atypical antidepressant mianserin exhibits agonist activity at κ-opioid receptors. Br J Pharmacol. 2012 Nov;167(6):1329-41. [2]. Roeder T. High-affinity antagonists of the locust neuronal octopamine receptor. Eur J Pharmacol. 1990 Nov 27;191(2):221-4. Chemical & Physical Properties Exact Mass 300.139313 PSA 6.48000 LogP 3.88880 InChIKey YNPFMWCWRVTGKJ-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1230 International Maritime Transport Danger Regulations: 1230 International Air Transport Danger Regulations: 1230 14.2 United Nations shipping name European Land Transport Dangerous Regulations: METHANOL, solution IMDG Code: METHANOL, solution IFRS: Methanol, solution 14.3 Transport hazard categories European land transport risk code: 3 (6.1) International sea transport risk code: 3 (6.1) International air transport risk code: 3 (6.1) 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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