CAS Number298-81-7
Synonyms8-MP; Puvalen; Xanthotoxin; Methoxsalen; Puvamet; Dermox; Meloxine; Vitpso; Meladinine; Deltasoralen; OXSORALEN; 9-methoxypsoralen; 8-methoxypsoralene; 8-MOP,9-Methoxyfuro[3,2-g][1]benzopyran-7-one,Ammoidin; Uvadex; 9-Methoxy-7H-furo[3,2-g]chromen-7-one; Ammodin; 8-MOP; 8-MOP,8-Methoxypsoralen,9-Methoxyfuro[3,2-g][1]benzopyran-7-one; EINECS 206-066-9; 6-Hydroxy-7-methoxy-5-benzofuranacrylic Acid d-Lactone; MFCD00005009; 8-Methoxypsoralen; Metoxin; 8-Methoxy[furano-3',2':6,7-coumarin]
Molecular FormulaC12H8O4
Molecular Weight216.19
Purity99%
Density1.4±0.1 g/cm3
Boiling Point414.8±45.0 °C at 760 mmHg
Melting Point148-150 °C (lit.)
Appearancecrystals
EINECS206-066-9
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 298-81-7 |
| Catalog No. | 2A-9011390 |
| Chinese Name | 花椒毒素； 8-甲氧基补骨脂素 |
| Synonyms | 8-MP; Puvalen; Xanthotoxin; Methoxsalen; Puvamet; Dermox; Meloxine; Vitpso; Meladinine; Deltasoralen; OXSORALEN; 9-methoxypsoralen; 8-methoxypsoralene; 8-MOP,9-Methoxyfuro[3,2-g][1]benzopyran-7-one,Ammoidin; Uvadex; 9-Methoxy-7H-furo[3,2-g]chromen-7-one; Ammodin; 8-MOP; 8-MOP,8-Methoxypsoralen,9-Methoxyfuro[3,2-g][1]benzopyran-7-one; EINECS 206-066-9; 6-Hydroxy-7-methoxy-5-benzofuranacrylic Acid d-Lactone; MFCD00005009; 8-Methoxypsoralen; Metoxin; 8-Methoxy[furano-3',2':6,7-coumarin] |
| Molecular Formula | C12H8O4 |
| Molecular Weight | 216.19 |
| Purity | 99 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 414.8±45.0 °C at 760 mmHg |
| Melting Point | 148-150 °C (lit.) |
| Appearance | crystals |
| Water Solubility | PRACTICALLY INSOLUBLE |
| Storage Condition | -20°C Freezer, Under Inert Atmosphere |
| Packaging | I; II; III |
| Application | Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used to treat psoriasis, eczema, vitiligo and some sun-exposed skin lymphomas, and is a P450 inhibitor. |
| EINECS | 206-066-9 |
| HTC | 2932999099 |
| PubChem ID | 24896845 |
| MDL Number | MFCD00005009 |
| SMILES | COc1c2OC(=O)C=Cc2cc3ccoc13 |
| InChI | 1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3 |
| InChI Key | QXKHYNVANLEOEG-UHFFFAOYSA-N |
| Beilstein/REAXYS | 196453 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1 |
| MSDS | msds/11390_1_298_81_7.pdf |
| Bioactivity | Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight.Target: CYP (cytochrome P-450)Methoxsalen is a drug used to treat psoriasis, eczema, vitiligo, and some cutaneous lymphomas in conjunction with exposing the skin to UVA light from lamps or sunlight. Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease. The dosage comes in 10 mg tablets, which are taken in the amount of 30 mg 75 minutes before a PUVA (psoralen + UVA) light treatment. Chemically, methoxsalen belongs to a class of organic natural molecules known asfuranocoumarins. They consist of coumarin annulated with furan.Administration of intra peritoneal (ip) methoxsalen significantly increased nicotine's Cmax, prolonged the plasma half-life (fourfold decrease) of nicotine, and increased its area under the curve (AUC) compared with ip vehicle treatment. Methoxsalen pretreatment prolonged the duration of nicotine-induced antinociception and hypothermia (15mg/kg, po) for periods up to 6- and 24-hr postnicotine administration, respectively. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Natural Products >> Phenylpropanoids Research Areas >> Inflammation/Immunology References [1]. Alsharari SD, et al. Pharmacokinetic and Pharmacodynamics Studies of Nicotine After Oral Administration in Mice: Effects of Methoxsalen, a CYP2A5/6 Inhibitor. Nicotine Tob Res. 2014 Jan;16(1):18-25. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 414.8±45.0 °C at 760 mmHg Melting Point 143-148 ºC Molecular Formula C12H8O4 Molecular Weight 216.189 Flash Point 204.7±28.7 °C Exact Mass 216.042252 PSA 52.58000 LogP 1.93 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.635 InChIKey QXKHYNVANLEOEG-UHFFFAOYSA-N SMILES COc1c2occc2cc2ccc(=O)oc12 Storage condition -20°C Freezer, Under Inert Atmosphere Water Solubility PRACTICALLY INSOLUBLE |
| Use of | Properties Articles68 Name methoxsalen Synonym More Synonyms Xanthotoxin Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Natural Products >> Phenylpropanoids Research Areas >> Inflammation/Immunology References Chemical & Physical Properties Molecular Formula C12H8O4 Exact Mass 216.042252 PSA 52.58000 Index of Refraction 1.635 InChIKey QXKHYNVANLEOEG-UHFFFAOYSA-N Water Solubility PRACTICALLY INSOLUBLE |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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