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Methoxamine hydrochloride structure, CAS 61-16-5

Methoxamine hydrochloride

CAS Number61-16-5

SynonymsMethoxamine HCl; (1RS,2SR)-2-amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol,hydrochloride; Methoxamini hydrochloridum; METHOXAMINE HYDROCHLORIDE; EINECS 200-499-7; Pressomin hydrochloride; Idasal; Vasoxyl hydrochloride; (1RS,2SR)-2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol,Hydrochlorid; MFCD00058607; Vasylox hydrochloride; 2-amino-1-(2,5-dimethoxyphenyl)-1-propanol monohydrochloride

Molecular FormulaC11H18ClNO3

Molecular Weight247.72

Purity98%

Density

Boiling Point368.4ºC at 760 mmHg

Melting Point212-216ºC

Flash Point

Appearancesolid

EINECS200-499-7

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Cat. No.: 2A-9011388 Purity: 98%
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Quality Control of [ 61-16-5 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number61-16-5
Catalog No.2A-9011388
Chinese Name甲氧胺 盐酸盐
SynonymsMethoxamine HCl; (1RS,2SR)-2-amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol,hydrochloride; Methoxamini hydrochloridum; METHOXAMINE HYDROCHLORIDE; EINECS 200-499-7; Pressomin hydrochloride; Idasal; Vasoxyl hydrochloride; (1RS,2SR)-2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol,Hydrochlorid; MFCD00058607; Vasylox hydrochloride; 2-amino-1-(2,5-dimethoxyphenyl)-1-propanol monohydrochloride
Molecular FormulaC11H18ClNO3
Molecular Weight247.72
Purity98
Boiling Point368.4ºC at 760 mmHg
Melting Point212-216ºC
Appearancesolid
Storage Condition2-8°C
ApplicationMethoxamine hydrochloride is an agonist of noradrenergic receptor α1.
EINECS200-499-7
PubChem ID24277785
MDL NumberMFCD00058607
SMILESCl[H].COc1ccc(OC)c(c1)C(O)C(C)N
InChI1S/C11H17NO3.ClH/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3;/h4-7,11,13H,12H2,1-3H3;1H
InChI KeyYGRFXPCHZBRUKP-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352116
Hazard SymbolsTransport
MSDSmsds/11388_1_61_16_5.pdf
BioactivityMethoxamine hydrochloride is a noradrenergic α1 agonistsup>[1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease Target Noradrenergic α1[1]. In Vitro Methoxamine produces a dose-related increase in force development of the cat papillary muscle that was selectively blocked by alpha-adrenergic antagonists. This is suggestive evidence of the presence of alpha-adrenergic receptors in ventricular myocardium[1]. Methoxamine greatly enhances bistable behavior in the decerebrate. Methoxamine approximately doubles the amplitude of IPIC without changing its onset voltage, its offset voltage, or its persistence[2]. References [1]. Rabinowitz B, et al. Positive inotropic effects of methoxamine: evidence for alpha-adrenergic receptors in ventricular myocardium. Am J Physiol. 1975 Sep;229(3):582-5. [2]. Lee RH, et al. Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alpha1 agonist methoxamine. J Neurophysiol. 1999 May;81(5):2164-74. Chemical & Physical Properties Boiling Point 368.4ºC at 760 mmHg Melting Point 212-216ºC Molecular Formula C11H18ClNO3 Molecular Weight 247.71900 Flash Point 176.6ºC Exact Mass 247.09800 PSA 64.71000 LogP 2.58670 Index of Refraction 1.5204 InChIKey YGRFXPCHZBRUKP-UHFFFAOYSA-N SMILES COc1ccc(OC)c(C(O)C(C)N)c1.Cl Storage condition 2-8°C
Use ofMethoxamine hydrochloride is a noradrenergic α1 agonistsup>[1]. Properties Articles36 Name 2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol,hydrochloride Synonym More Synonyms methoxamine hydrochloride Biological Activity Description Methoxamine hydrochloride is a noradrenergic α1 agonistsup>[1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease Noradrenergic α1[1]. In Vitro Methoxamine produces a dose-related increase in force development of the cat papillary muscle that was selectively blocked by alpha-adrenergic antagonists. This is suggestive evidence of the presence of alpha-adrenergic receptors in ventricular myocardium[1]. Methoxamine greatly enhances bistable behavior in the decerebrate. Methoxamine approximately doubles the amplitude of IPIC without changing its onset voltage, its offset voltage, or its persistence[2]. References [1]. Rabinowitz B, et al. Positive inotropic effects of methoxamine: evidence for alpha-adrenergic receptors in ventricular myocardium. Am J Physiol. 1975 Sep;229(3):582-5. [2]. Lee RH, et al. Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alpha1 agonist methoxamine. J Neurophysiol. 1999 May;81(5):2164-74. Chemical & Physical Properties Exact Mass 247.09800 PSA 64.71000 LogP 2.58670 Index of Refraction 1.5204 InChIKey YGRFXPCHZBRUKP-UHFFFAOYSA-N
Transport InfoProduct name: Purity: 95.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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