CAS Number519-02-8
SynonymsMaca extract; Matrine; Matrines; Matridin-15-on; EINECS 610-750-6; MATRINIUM; MATRENE; Sophocarpidine; MASSMARK 1621; matridin-15-one; MFCD00210527
Molecular FormulaC15H24N2O
Molecular Weight248.36
Purity98%
Density1.2±0.1 g/cm3
Boiling Point396.7±31.0 °C at 760 mmHg
Melting Point77°C
AppearanceWhite to yellow powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 519-02-8 |
| Catalog No. | 2A-9011296 |
| Chinese Name | 苦参碱 |
| Synonyms | Maca extract; Matrine; Matrines; Matridin-15-on; EINECS 610-750-6; MATRINIUM; MATRENE; Sophocarpidine; MASSMARK 1621; matridin-15-one; MFCD00210527 |
| Molecular Formula | C15H24N2O |
| Molecular Weight | 248.36 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 396.7±31.0 °C at 760 mmHg |
| Melting Point | 77°C |
| Appearance | White to yellow powder |
| Storage Condition | 1. Packages should be stored in a cool, ventilated |
| Application | Matrine (Sophocarpidine; α-Matrine) is an alkaloid derived from plants, has anti-tumor activity, and is a kappa opioid receptor agonist. |
| HTC | 1302199001 |
| PubChem ID | 329818010 |
| MDL Number | MFCD00210527 |
| SMILES | O=C1CCCC2C3CCCN4CCCC(CN12)C34 |
| InChI | 1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1 |
| InChI Key | ZSBXGIUJOOQZMP-JLNYLFASSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352200 |
| MSDS | msds/11296_1_519_02_8.pdf |
| Use of | Properties Name matrine Synonym More Synonyms Matrine Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Autophagy >> Mitophagy Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Natural Products >> Alkaloid Research Areas >> Cancer References [3]. Li X, et al. Regulation of endothelial nitric oxide synthase and asymmetric dimethylarginine by matrine attenuates isoproterenol-induced acute myocardial injury in rats. J Pharm Pharmacol. 2012 Aug;64(8):1107-18. [4]. Zhang B, et al. Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice. Eur J Pharm Sci. 2011 Dec 18;44(5):573-9. Chemical & Physical Properties Molecular Formula C15H24N2O Exact Mass 248.188858 PSA 23.55000 Index of Refraction 1.581 InChIKey ZSBXGIUJOOQZMP-JLNYLFASSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C15-H24-N2-O MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 18,2555,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 18,214,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 64850 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,201,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 74150 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,201,1992 Safety Information Hazard Codes Xn: Harmful; HS Code 1302199001 Synthetic Route Oxysophocarpine CAS#:26904-64-3 oxymatrine CAS#:16837-52-8 CAS#:519-02-8 tert-butyl pyri... CAS#:65321-36-0 CAS#:519-02-8 Literature: Boiteau, Laurent; Boivin, Jean; Liard, Annie; Quiclet-Sire, Beatrice; Zard, Samir Z. Angewandte Chemie - International Edition, 1998 , vol. 37, # 8 p. 1128 - 1130 CAS#:208714-36-7 CAS#:519-02-8 Literature: Boiteau, Laurent; Boivin, Jean; Liard, Annie; Quiclet-Sire, Beatrice; Zard, Samir Z. Angewandte Chemie - International Edition, 1998 , vol. 37, # 8 p. 1128 - 1130 Precursor & DownStream Precursor 4 CAS#:26904-64-3 Oxysophocarpine CAS#:16837-52-8 oxymatrine CAS#:65321-36-0 tert-butyl pyri... CAS#:4695-77-6 tert-butyl 1,4,... DownStream 3 CAS#:641-39-4 Allomatrine CAS#:6483-15-4 Sophocarpine CAS#:16837-52-8 oxymatrine |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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