CAS Number10262-69-8
Synonyms3-(9,10-Dihydro-9,10-ethanoanthracen-9-yl)-N-methylpropan-1-amine; Deprilept; Dibencycladine; N-methyl-9,10-ethanoanthracene-9(10H)-propanamine; Maprotilina; Maprotylina [Polish]; Maprotilinum; MFCD00661057; Maprotilin; Maprotilinum [INN-Latin]; EINECS 233-599-4; 9-[3-(methylamino)propyl]-9,10-dihydro-9,10-ethanoanthracene; Maprotilina [INN-Spanish]; Maprotylina
Molecular FormulaC20H23N
Molecular Weight313.86
Purity98.00%
Density1.08 g/cm3
Boiling Point399.6ºC at 760 mmHg
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 10262-69-8 |
| Catalog No. | 2A-9011291 |
| Chinese Name | 马普替林 |
| Synonyms | 3-(9,10-Dihydro-9,10-ethanoanthracen-9-yl)-N-methylpropan-1-amine; Deprilept; Dibencycladine; N-methyl-9,10-ethanoanthracene-9(10H)-propanamine; Maprotilina; Maprotylina [Polish]; Maprotilinum; MFCD00661057; Maprotilin; Maprotilinum [INN-Latin]; EINECS 233-599-4; 9-[3-(methylamino)propyl]-9,10-dihydro-9,10-ethanoanthracene; Maprotilina [INN-Spanish]; Maprotylina |
| Molecular Formula | C20H23N |
| Molecular Weight | 313.86 |
| Purity | 98.00 |
| Density | 1.08 g/cm3 |
| Boiling Point | 399.6ºC at 760 mmHg |
| Storage Condition | Seal in a cool, dry place. |
| Packaging | III |
| Application | Maprotiline is a highly selective noradrenergic reuptake blocker with strong antidepressant efficacy. Maprotiline induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1. Mapro |
| HTC | 2921499090 |
| PubChem ID | 329817742 |
| MDL Number | MFCD00079464 |
| SMILES | Cl.CNCCCC12CCC(c3ccccc13)c4ccccc24 |
| InChI | 1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H |
| InChI Key | NZDMFGKECODQRY-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/11291_1_10262_69_8.pdf |
| Use of | Maprotiline is a highly selective noradrenergic reuptake blocker, has strong antidepressant efficacy. Maprotiline induces cancer cells apoptosis by targeting ERK signaling pathway and CRABP1. Maprotiline restrains cell proliferation and metastasis, exhibits anticancer effect[1][2]. Properties Name maprotiline Synonym More Synonyms Maprotiline Biological Activity Description Maprotiline is a highly selective noradrenergic reuptake blocker, has strong antidepressant efficacy. Maprotiline induces cancer cells apoptosis by targeting ERK signaling pathway and CRABP1. Maprotiline restrains cell proliferation and metastasis, exhibits anticancer effect[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Neurological Disease References [1]. Gunduz O, et al. Analysis of the anti-allodynic effects of combination of a synthetic cannabinoid and a selective noradrenaline re-uptake inhibitor in nerve injury-induced neuropathic mice. Eur J Pain. 2016 Mar. 20(3):465-71. [2]. Zheng C, et al. Maprotiline Suppresses Cholesterol Biosynthesis and Hepatocellular Carcinoma Progression Through Direct Targeting of CRABP1. Front Pharmacol. 2021 May 20. 12:689767. Chemical & Physical Properties Molecular Formula C20H23N Exact Mass 277.18300 PSA 12.03000 LogP 4.60230 Index of Refraction 1.599 InChIKey QSLMDECMDJKHMQ-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 9,10-Ethanoanthracene-9(10H)-propylamine, N-methyl- CAS REGISTRY NUMBER : 10262-69-8 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - child DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - coma Vascular - BP elevation not characterized in autonomic section REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,260,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity REFERENCE : HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 55,527,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea REFERENCE : APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 40,235,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity REFERENCE : HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 55,527,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity REFERENCE : HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 55,527,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 40,235,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity REFERENCE : HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 55,527,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Cardiac - EKG changes not diagnostic of specified effects Related to Chronic Data - death REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1709,1980 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Cardiac - EKG changes not diagnostic of specified effects REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 51,43,1982 Safety Information RIDADR 3249 Packaging Group III Hazard Class 6.1(b) HS Code 2921499090 Synthetic Route CAS#:90-44-8 Maprotiline CAS#:10262-69-8 Literature: Helvetica chimica acta, , vol. 52, # 6 p. 1385 - 1395 3-[Dibenzo[b,e]... CAS#:6812-49-3 Maprotiline CAS#:10262-69-8 Literature: Helvetica chimica acta, , vol. 52, # 6 p. 1385 - 1395 3-(9-Anthryl)pr... CAS#:41034-83-7 Maprotiline CAS#:10262-69-8 Literature: Helvetica chimica acta, , vol. 52, # 6 p. 1385 - 1395 Precursor & DownStream Precursor 5 CAS#:23716-34-9 3-[Dibenzo[b,e]... CAS#:90-44-8 CAS#:6812-49-3 3-[Dibenzo[b,e]... CAS#:41034-83-7 3-(9-Anthryl)pr... DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Manidipine | 120092-68-4 | 2A-9011286 |
| Manidipine dihydrochloride | 89226-75-5 | 2A-9011287 |
| Mannitol nitrate | 130-39-2 | 2A-9011288 |
| Manozodil | 77528-67-7 | 2A-9011289 |
| Manzamine A | 104196-68-1 | 2A-9011290 |
| Marein | 535-96-6 | 2A-9011293 |
| Marigold P.E. | 2A-302377 | 2A-9011294 |
| Masoprocol | 127757-92-0 | 2A-9011295 |
| Matrinium | 519-02-8 | 2A-9011296 |
| Mazindol | 22232-71-9 | 2A-9011297 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS