CAS Number56341-08-3
Synonyms1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)-2-(tert-butylamino)ethanol; 1-[4-azanyl-3-chloro-5-(trifluoromethyl)phenyl]-2-(tert-butylamino)ethanol; Ambuterol
Molecular FormulaC13H18ClF3N2O
Molecular Weight347.20
Purity98%
Density1.278g/cm3
Boiling Point375.9ºC at 760mmHg
Melting Point85-87ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 56341-08-3 |
| Catalog No. | 2A-9011265 |
| Chinese Name | 马布台诺 |
| Synonyms | 1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)-2-(tert-butylamino)ethanol; 1-[4-azanyl-3-chloro-5-(trifluoromethyl)phenyl]-2-(tert-butylamino)ethanol; Ambuterol |
| Molecular Formula | C13H18ClF3N2O |
| Molecular Weight | 347.20 |
| Purity | 98 |
| Density | 1.278g/cm3 |
| Boiling Point | 375.9ºC at 760mmHg |
| Melting Point | 85-87ºC |
| Storage Condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Application | Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabtrol inhibits the proliferation and increase of intracellular Ca2+ induced by PDGF-BB. Mabtrol inhibits the pr |
| HTC | 2922199090 |
| PubChem ID | 329754035 |
| MDL Number | MFCD00941398 |
| SMILES | Cl.CC(C)(C)NCC(O)c1cc(Cl)c(N)c(c1)C(F)(F)F |
| InChI | 1S/C13H18ClF3N2O.ClH/c1-12(2,3)19-6-10(20)7-4-8(13(15,16)17)11(18)9(14)5-7;/h4-5,10,19-20H,6,18H2,1-3H3;1H |
| InChI Key | MMCDXJOMPMIKGP-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/11265_1_56341_08_3.pdf |
| Use of | Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB[1][2]. Properties Name mabuterol Synonym More Synonyms Mabuterol Biological Activity Description Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Beta-2 adrenergic receptor References [1]. Yamamoto I, et al. Enzyme immunoassay for mabuterol, a selective beta 2-adrenergic stimulant in the trachea. J Immunoassay. 1985;6(3):261-76. [2]. Yaru Gu, et al. Inhibitory effect of mabuterol on proliferation of rat ASMCs induced by PDGF-BB via regulating [Ca2+]i and mitochondrial fission/fusion. Interactions, 2019, 307: 63-72. Chemical & Physical Properties Exact Mass 310.10600 PSA 58.28000 LogP 4.33460 Index of Refraction 1.516 InChIKey JSJCTEKTBOKRST-UHFFFAOYSA-N Safety Information HS Code 2922199090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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