CAS Number74050-98-9
SynonymsPerketan; R41468; Taseron; EINECS 277-680-2; 3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}ethyl)quinazoline-2,4(1H,3H)-dione; MFCD00083392; 3-{2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl}-2,4(1H,3H)-quinazolinedione; Sufrexal; Ketensin; Serepress; Serefrex; KET; R41,468; 3-{2-[4-(4-Fluorobenzoyl)piperidin-1-yl]ethyl}quinazoline-2,4(1H,3H)-dione; R 41,468; Ketanserin
Molecular FormulaC22H22O3N3F1
Molecular Weight395.43
Purity98%
Density1.3±0.1 g/cm3
Melting Point227-235°C
AppearanceWhite-light yellow crystal-powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 74050-98-9 |
| Catalog No. | 2A-9011097 |
| Chinese Name | 凯他色林 |
| Synonyms | Perketan; R41468; Taseron; EINECS 277-680-2; 3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}ethyl)quinazoline-2,4(1H,3H)-dione; MFCD00083392; 3-{2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl}-2,4(1H,3H)-quinazolinedione; Sufrexal; Ketensin; Serepress; Serefrex; KET; R41,468; 3-{2-[4-(4-Fluorobenzoyl)piperidin-1-yl]ethyl}quinazoline-2,4(1H,3H)-dione; R 41,468; Ketanserin |
| Molecular Formula | C22H22O3N3F1 |
| Molecular Weight | 395.43 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Melting Point | 227-235°C |
| Appearance | White-light yellow crystal-powder |
| Water Solubility | DMF: 10 mg/mL, clear, colorless |
| Storage Condition | 2-8°C |
| Application | Ketanserin is a selective 5-HT receptor antagonist. Ketanserin also inhibits hERG currents (IhERG) with an IC50 of 0.11 μM, and this effect is concentration-dependent. |
| HTC | 2933990090 |
| MDL Number | MFCD00083392 |
| SMILES | O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 |
| InChI | InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29) |
| InChI Key | FPCCSQOGAWCVBH-UHFFFAOYSA-N |
| MSDS | msds/11097_1_74050_98_9.pdf |
| Use of | Ketanserin is a selective 5-HT receptor antagonist. Ketanserin also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM). Properties Name ketanserin Synonym More Synonyms Ketanserin Biological Activity Description Ketanserin is a selective 5-HT receptor antagonist. Ketanserin also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM). Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Neurological Disease In Vivo Ketanserin is a 5-HT2A receptor antagonist. Ketanserin significantly reduces BDNF protein levels in numerous brain regions (CA1 and CA3 of the hippocampus, prefrontal cortex, central amygdaloid nucleus, dorsomedial hypothalamic nucleus, dentate gyrus, shell of the nucleus accumbens and midbrain periaqueductal gray). 5-HT2A antagonist Ketanserin can significantly reduce BDNF mRNA levels in various brain regions[4]. References [1]. Tang Q, et al. The 5-HT2 antagonist Ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels. Br J Pharmacol. 2008 Oct;155(3):365-73. [2]. Khan N, et al. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug Des Devel Ther. 2015 Jul 6;9:3497-506. [3]. Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340(2):369-76. [4]. Jiang DG, et al. Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress. Neural Regen Res. 2016 Sep;11(9):1471-1479. Chemical & Physical Properties Molecular Formula C22H22FN3O3 Exact Mass 395.164520 PSA 75.17000 Index of Refraction 1.593 InChIKey FPCCSQOGAWCVBH-UHFFFAOYSA-N Safety Information Hazard Codes Xn WGK Germany 3 RTECS VA1411190 HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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