CAS Number74103-07-4
SynonymsKetorolac tromethamine; 2-amino-2-(hydroxymethyl)propane-1,3-diol,5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; Ketorolac tris salt; rac Ketorolac Tromethamine Salt; (±)-Ketorolac Tromethamine Salt; MFCD00887595; 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate; Ketorolac (tromethamine salt)
Molecular FormulaC19H24N2O6
Molecular Weight376.40
Purity98%
Boiling Point493.2ºC at 760 mmHg
Melting Point160-161ºC
Appearancecrystallization
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 74103-07-4 |
| Catalog No. | 2A-9011101 |
| Chinese Name | 酮咯酸氨丁三醇 |
| Synonyms | Ketorolac tromethamine; 2-amino-2-(hydroxymethyl)propane-1,3-diol,5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; Ketorolac tris salt; rac Ketorolac Tromethamine Salt; (±)-Ketorolac Tromethamine Salt; MFCD00887595; 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate; Ketorolac (tromethamine salt) |
| Molecular Formula | C19H24N2O6 |
| Molecular Weight | 376.40 |
| Purity | 98 |
| Boiling Point | 493.2ºC at 760 mmHg |
| Melting Point | 160-161ºC |
| Appearance | crystallization |
| Water Solubility | H2O: 15 mg/mL stable at least one month at −20 °C. |
| Storage Condition | Hygroscopic, Refrigerator, Under Inert Atmosphere |
| Packaging | II |
| Application | Ketorolac tromethamine salt is a non-steroidal anti-inflammatory agent and a non-selective COX inhibitor with IC50 values of 20 nM and 120 nM for COX-1 and COX-2 respectively. |
| HTC | 2942000000 |
| PubChem ID | 329823160 |
| MDL Number | MFCD00887595 |
| SMILES | NC(CO)(CO)CO.OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3 |
| InChI | 1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2 |
| InChI Key | BWHLPLXXIDYSNW-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(a) |
| MSDS | msds/11101_1_74103_07_4.pdf |
| Bioactivity | Ketorolac tromethamine salt is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Related Catalog Research Areas >> Inflammation/Immunology Target COX-1:20 nM (IC50) COX-2:120 nM (IC50) In Vitro Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2[1]. In Vivo Ketorolac tromethamine (0.4%) causes nearly complete inhibition on LPS endotoxin-induced increases in FITC-dextran in the anterior chamber, and increases in aqueous PGE2 concentrations in the aqueous humor in rabbits[1].Ketorolac (30 mg/kg, i.v.) rapidly reverses hyperalgesia in rats. Ketorolac also reduces carrageenan-induced hyperalgesia and paw PG production, and causes reduction in PGE2 levels in rats[1]. Ketorolac (4 mg/kg/day, p.o.) has no detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket in rats[2]. Ketorolac (60 μg/10 μL) reduces the histological changes such as ischemic cell death, including cytoplasmic eosinophilia with disintegration of cytoarchitecture and nuclear pyknosis in rats. Ketorolac also effectively reduces neuronal death and improves hindlimb motor function, and the long-term survival is similar to that in the control group[3]. Animal Admin Rats[2] Treated rats receive oral doses of 1 mL aqueous solution of paracetamol (80 mg/kg/rat/day), Ketorolac (4 mg/kg/day) or etoricoxib (10 mg/kg/day) administered by gavage from the day of surgery until death, 2 weeks later. Control rats receive tap water (1 mL/day by gavage). The animals are housed under climate-controlled environment (12 h light/12 h dark, 20-24ºC) with free access to standard laboratory chow and tap water[2]. References [1]. Waterbury LD, et al. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22(6):1133-40. [2]. Fracon RN, et al. Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats. J Appl Oral Sci. 2010 Dec;18(6):630-4. [3]. Hsieh YC, et al. Intrathecal ketorolac pretreatment reduced spinal cord ischemic injury in rats. Anesth Analg. 2005 Apr;100(4):1134-9. Chemical & Physical Properties Boiling Point 493.2ºC at 760 mmHg Melting Point 160-161ºC Molecular Formula C19H24N2O6 Molecular Weight 376.404 Flash Point 252.1ºC Exact Mass 376.163422 PSA 146.01000 LogP 0.65210 InChIKey BWHLPLXXIDYSNW-UHFFFAOYSA-N SMILES NC(CO)(CO)CO.O=C(c1ccccc1)c1ccc2n1CCC2C(=O)O Storage condition Hygroscopic, Refrigerator, Under Inert Atmosphere Water Solubility H2O: 15 mg/mL stable at least one month at −20 °C., soluble |
| Use of | Ketorolac tromethamine salt is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Properties Articles64 Name ketorolac tromethamine Synonym More Synonyms Ketorolac tromethamine Biological Activity Description Ketorolac tromethamine salt is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Related Catalog Research Areas >> Inflammation/Immunology COX-1:20 nM (IC50) COX-2:120 nM (IC50) In Vitro Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2[1]. References [1]. Waterbury LD, et al. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22(6):1133-40. [2]. Fracon RN, et al. Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats. J Appl Oral Sci. 2010 Dec;18(6):630-4. [3]. Hsieh YC, et al. Intrathecal ketorolac pretreatment reduced spinal cord ischemic injury in rats. Anesth Analg. 2005 Apr;100(4):1134-9. Chemical & Physical Properties Molecular Formula C19H24N2O6 Exact Mass 376.163422 PSA 146.01000 LogP 0.65210 InChIKey BWHLPLXXIDYSNW-UHFFFAOYSA-N Storage condition Hygroscopic, Refrigerator, Under Inert Atmosphere |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Ketorolac tris salt) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (Ketorolac tris salt) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Ketorolac tris salt) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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