CAS Number58186-27-9
Synonyms6-(10-Hydroxydecyl)ubiquinone; Raxone; Idebenone [INN:JAN]; Daruma; Catena; CV 2619; 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone; Sovrima; 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylbenzo-1,4-quinone; Idebenone; Idebenonum [Latin]; 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-cyclohexa-2,5-diene-1,4-dione; 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione; MFCD00274552; UNII-HB6PN45W4J; 2,3-Dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone; 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione; Lucenabol; Idebenone (JAN); Mnesis; Avan; Idebenona [Spanish]
Molecular FormulaC19H30O5
Molecular Weight338.44
Purity≥98 (HPLC)%
Density1.1±0.1 g/cm3
Boiling Point497.3±45.0 °C at 760 mmHg
Melting Point52-550C
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 58186-27-9 |
| Catalog No. | 2A-9010893 |
| Chinese Name | 艾地苯醌 |
| Synonyms | 6-(10-Hydroxydecyl)ubiquinone; Raxone; Idebenone [INN:JAN]; Daruma; Catena; CV 2619; 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone; Sovrima; 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylbenzo-1,4-quinone; Idebenone; Idebenonum [Latin]; 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-cyclohexa-2,5-diene-1,4-dione; 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione; MFCD00274552; UNII-HB6PN45W4J; 2,3-Dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone; 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione; Lucenabol; Idebenone (JAN); Mnesis; Avan; Idebenona [Spanish] |
| Molecular Formula | C19H30O5 |
| Molecular Weight | 338.44 |
| Purity | ≥98 (HPLC) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 497.3±45.0 °C at 760 mmHg |
| Melting Point | 52-550C |
| Appearance | powder |
| Water Solubility | Water solubility: insoluble; slightly soluble: met |
| Storage Condition | Room temp |
| Application | Idebenone is a synthetic variant of coenzyme Q10 originally used for Alzheimer's disease and other cognitive deficits. |
| PubChem ID | 329815386 |
| MDL Number | MFCD00274552 |
| SMILES | O=C(C(OC)=C1OC)C(CCCCCCCCCCO)=C(C)C1=O |
| InChI | 1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3 |
| InChI Key | JGPMMRGNQUBGND-UHFFFAOYSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352204 |
| Hazard Symbols | Transport |
| MSDS | msds/10893_1_58186_27_9.pdf |
| Bioactivity | Idebenone is a synthetic variant of coenzyme Q10 (CoQ10), which initially developed for the treatment of Alzheimer's disease and other cognitive defects.Target: OthersIdebenone is a synthetic variant of coenzyme Q10 (CoQ10), which initially developed for the treatment of Alzheimer's disease and other cognitive defects. Idebenone was generally well tolerated with similar numbers of adverse events in each group. One child receiving high-dose idebenone developed neutropenia after 6 months, which resolved after discontinuation of treatment. 8OH2′dG concentrations were not increased, and did not significantly change with idebenone treatment [1]. The 2-year efficacy and safety of idebenone were studied in a prospective, randomized, double-blind multicentre study in 3 parallel groups of patients with dementia of the Alzheimer type (DAT) of mild to moderate degree. A total of 450 patients were randomized to either placebo for 12 months, followed by idebenone 90 mg tid for another 12 months (n = 153) or idebenone 90 mg tid for 24 months (n = 148) or 120 mg tid for 24 months (n = 149). idebenone showed statistically significant dose-dependent improvement in the primary efficacy variable ADAS-Total and in all the secondary efficacy variables [2]. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Quinones Research Areas >> Neurological Disease References [1]. Di Prospero, N.A., et al., Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomised, placebo-controlled trial. The Lancet Neurology, 2007. 6(10): p. 878-886. [2]. Gutzmann, H. and D. Hadler, Sustained efficacy and safety of idebenone in the treatment of Alzheimer's disease: update on a 2-year double-blind multicentre study, in Alzheimer's Disease-From Basic Research to Clinical Applications. 1998, Springer. p. 301-310. [3]. Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 497.3±45.0 °C at 760 mmHg Melting Point 52-550C Molecular Formula C19H30O5 Molecular Weight 338.439 Flash Point 170.1±22.2 °C Exact Mass 338.209320 PSA 72.83000 LogP 3.49 Vapour Pressure 0.0±2.9 mmHg at 25°C Index of Refraction 1.502 InChIKey JGPMMRGNQUBGND-UHFFFAOYSA-N SMILES COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O Storage condition Room temp |
| Use of | Properties Articles15 Name idebenone Synonym More Synonyms Idebenone Biological Activity Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Quinones Research Areas >> Neurological Disease References [1]. Di Prospero, N.A., et al., Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomised, placebo-controlled trial. The Lancet Neurology, 2007. 6(10): p. 878-886. [2]. Gutzmann, H. and D. Hadler, Sustained efficacy and safety of idebenone in the treatment of Alzheimer's disease: update on a 2-year double-blind multicentre study, in Alzheimer's Disease-From Basic Research to Clinical Applications. 1998, Springer. p. 301-310. [3]. Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153. Chemical & Physical Properties Molecular Formula C19H30O5 Exact Mass 338.209320 PSA 72.83000 Index of Refraction 1.502 InChIKey JGPMMRGNQUBGND-UHFFFAOYSA-N SMILES COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O Storage condition Room temp |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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