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Idazoxan hydrochloride structure, CAS 79944-56-2

Idazoxan hydrochloride

CAS Number79944-56-2

SynonymsIdazoxan Hydrochloride; Melanotan II; IdazoxanHCl

Molecular FormulaC11H13ClN2O2

Molecular Weight240.69

Purity98%

Density

Boiling Point397ºC at 760 mmHg

Melting Point

Flash Point

Appearance

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Cat. No.: 2A-9010892 Purity: 98%
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Quality Control of [ 79944-56-2 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number79944-56-2
Catalog No.2A-9010892
Chinese Name盐酸咪唑克生
SynonymsIdazoxan Hydrochloride; Melanotan II; IdazoxanHCl
Molecular FormulaC11H13ClN2O2
Molecular Weight240.69
Purity98
Boiling Point397ºC at 760 mmHg
Storage Condition2-8°C, sealed, dry
ApplicationIdazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenergic receptor antagonist and an imidazoline receptor (IRs) antagonist that competitively antagonizes the central antihypertensive effect
PubChem ID24278493
MDL NumberMFCD00069293
SMILESCl.C1CN=C(N1)C2COc3ccccc3O2
InChI1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H
InChI KeyMYUBYOVCLMEAOH-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard SymbolsTransport
MSDSmsds/10892_1_79944_56_2.pdf
BioactivityIdazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like drugs (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson's disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism[1][2]. Related Catalog Research Areas >> Endocrinology Target α2-adrenoceptor[1]; Imidazoline receptors (IRs)[2] In Vivo Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25 mg/kg. Idazoxan (0.3 and 2.5 mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol[1]. Animal Model: Male CD-COBS rats injected with 1 mg/kg haloperidol[1] Dosage: 0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0 mg/kg Administration: Subcutaneous injection; for 1 hour Result: Potently reversed haloperidol-induced catalepsy with an ED50 of 0.25 mg/kg. References [1]. Roberto W Invernizzi, et al. The α2-Adrenoceptor Antagonist Idazoxan Reverses Catalepsy Induced by Haloperidol in Rats Independent of Striatal Dopamine Release: Role of Serotonergic Mechanisms. Neuropsychopharmacology volume 28, pages872-879 (2003). [2]. Bousquet P, et al. Participation of imidazoline receptors and alpha(2-)-adrenoceptors in the central hypotensive effects of imidazoline-like drugs. Ann N Y Acad Sci. 1999 Jun 21;881:272-8. Chemical & Physical Properties Boiling Point 397ºC at 760 mmHg Molecular Formula C11H13ClN2O2 Molecular Weight 240.68600 Flash Point 193.9ºC Exact Mass 240.06700 PSA 42.85000 LogP 1.39450 InChIKey MYUBYOVCLMEAOH-UHFFFAOYSA-N SMILES Cl.c1ccc2c(c1)OCC(C1=NCCN1)O2
Use ofIdazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like drugs (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson's disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism[1][2]. Properties Articles36 Name Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride Synonym More Synonyms Idazoxan Hydrochloride Biological Activity Description Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like drugs (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson's disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism[1][2]. Related Catalog Research Areas >> Endocrinology α2-adrenoceptor[1]; Imidazoline receptors (IRs)[2] References [1]. Roberto W Invernizzi, et al. The α2-Adrenoceptor Antagonist Idazoxan Reverses Catalepsy Induced by Haloperidol in Rats Independent of Striatal Dopamine Release: Role of Serotonergic Mechanisms. Neuropsychopharmacology volume 28, pages872-879 (2003). [2]. Bousquet P, et al. Participation of imidazoline receptors and alpha(2-)-adrenoceptors in the central hypotensive effects of imidazoline-like drugs. Ann N Y Acad Sci. 1999 Jun 21;881:272-8. Chemical & Physical Properties Exact Mass 240.06700 PSA 42.85000 LogP 1.39450 InChIKey MYUBYOVCLMEAOH-UHFFFAOYSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Idazoxan hydrochloride) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (Idazoxan hydrochloride) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Idazoxan hydrochloride) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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