CAS Number11021-14-0
SynonymsEINECS 234-253-5; Ginsenoside Rc; MFCD00133368; Ginsenoside-Rc from Panax ginseng (Korean ginseng) root
Molecular FormulaC53H90O22
Molecular Weight1079.27
Purity≥98 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point1128.3±65.0 °C at 760 mmHg
Appearancepowder
EINECS234-253-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 11021-14-0 |
| Catalog No. | 2A-9010735 |
| Chinese Name | 人参皂苷Rc |
| Synonyms | EINECS 234-253-5; Ginsenoside Rc; MFCD00133368; Ginsenoside-Rc from Panax ginseng (Korean ginseng) root |
| Molecular Formula | C53H90O22 |
| Molecular Weight | 1079.27 |
| Purity | ≥98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 1128.3±65.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | Seal in a cool, dry place at 2-8ºC. |
| Application | Ginsenoside Rc is one of the major ginsenosides, Ginsenoside Rc enhances GABA receptor A (GABAA)-mediated ion channels (IGABA). Ginsenoside Rc also inhibits TNF-α and IL-1β expression. |
| EINECS | 234-253-5 |
| PubChem ID | 24895029 |
| MDL Number | MFCD00133368 |
| SMILES | C\C(C)=C\CCC(C)(OC1OC(COC2OC(CO)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C |
| InChI | 1S/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-68-45-41(65)36(60)28(21-56)69-45)24-11-16-52(7)33(24)25(57)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)35(59)27(20-55)71-48)74-46-42(66)38(62)34(58)26(19-54)70-46/h10,24-48,54-67H,9,11-22H2,1-8H3 |
| InChI Key | JDCPEKQWFDWQLI-UHFFFAOYSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352201 |
| Hazard Symbols | Transport |
| MSDS | msds/10735_1_11021_14_0.pdf |
| Bioactivity | Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptorA (GABAA)-mediated ion channel currents (IGABA). Ginsenoside Rc inhibits the expression of TNF-α and IL-1β. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Apoptosis >> TNF Receptor Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Target GABA Receptor TNF-α IL-1β In Vitro Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances γ-aminobutyric acid (GABA) receptorA (GABAA)-mediated ion channel currents. Ginsenoside Rc enhances GABA-mediated ion currents in oocytes expressing the GABAA receptor[1]. Ginsenoside Rc significantly inhibits the expression of macrophage-derived cytokines, such as TNF-α and IL-1β. Ginsenoside Rc also markedly suppresses the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Ginsenoside Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling. Ginsenoside Rc suppresses the nuclear translocation of phospho-ATF-2 and phospho-FRA-1, whereas the translocation of p65 at its peak time points (30 and 60 min) is not decreased by Ginsenoside Rc treatment. Ginsenoside Rc regulates the expression of the proinflammatory cytokine TNF-α, which is produced by macrophages, by suppressing AP-1 activation[2]. Kinase Assay To evaluate the effects of Ginsenoside Rc on kinase activity, immunoprecipitated TBK1, IKKε, and p38 are incubated in reaction buffer in the presence or absence of Ginsenoside Rc. The reactions are initiated by the addition of Mg-ATP. After a 30 min incubation at 30°C, the reactions are stopped by the addition of sample buffer and the samples are boiled. Kinase activity is assessed by immunoblotting with antibodies against the phospho-forms of IKKε, IRF-3, and ATF-2[2]. References [1]. Lee BH, et al. Effects of Ginsenoside Metabolites on GABAA Receptor-Mediated Ion Currents. J Ginseng Res. 2012 Jan;36(1):55-60. [2]. Yu T, et al. Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-bindingkinase 1/interferon regulatory factor-3 and p38/ATF-2. J Ginseng Res. 2017 Apr;41(2):127-133. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 1128.3±65.0 °C at 760 mmHg Molecular Formula C53H90O22 Molecular Weight 1079.269 Flash Point 636.2±34.3 °C Exact Mass 1078.592407 PSA 357.06000 LogP 5.10 Vapour Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.622 InChIKey JDCPEKQWFDWQLI-LUQKBWBOSA-N SMILES CC(C)=CCCC(C)(OC1OC(COC2OC(CO)C(O)C2O)C(O)C(O)C1O)C1CCC2(C)C1C(O)CC1C3(C)CCC(OC4OC(CO)C(O)C(O)C4OC4OC(CO)C(O)C(O)C4O)C(C)(C)C3CCC12C Storage condition 2-8°C |
| Use of | Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptorA (GABAA)-mediated ion channel currents (IGABA). Ginsenoside Rc inhibits the expression of TNF-α and IL-1β. Properties Articles23 Name ginsenoside Rc Synonym More Synonyms Ginsenoside Rc Biological Activity Description Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptorA (GABAA)-mediated ion channel currents (IGABA). Ginsenoside Rc inhibits the expression of TNF-α and IL-1β. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Apoptosis >> TNF Receptor Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease GABA Receptor References [1]. Lee BH, et al. Effects of Ginsenoside Metabolites on GABAA Receptor-Mediated Ion Currents. J Ginseng Res. 2012 Jan;36(1):55-60. Chemical & Physical Properties Molecular Formula C53H90O22 Exact Mass 1078.592407 PSA 357.06000 Index of Refraction 1.622 InChIKey JDCPEKQWFDWQLI-LUQKBWBOSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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| Ginsenoside F3 | 62025-50-7 | 2A-9010732 |
| Ginsenoside Rb1 | 41753-43-9 | 2A-9010733 |
| Ginsenoside Rb3 | 68406-26-8 | 2A-9010734 |
| Ginsenoside Re | 52286-59-6 | 2A-9010736 |
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| Ginsenoside Rg2 | 52286-74-5 | 2A-9010738 |
| Ginsenoside Rg3 | 14197-60-5 | 2A-9010739 |
| Ginsenoside Rh1 | 63223-86-9 | 2A-9010740 |
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