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Fumonisin B1 structure, CAS 116355-83-0

Fumonisin B1

CAS Number116355-83-0

SynonymsFumonisin B1 from Fusarium moniliforme,Macrofusine; Fumonisin B1; FB1

Molecular FormulaC34H59NO15

Molecular Weight721.83

Purity≥98 (HPLC)%

Density1.3±0.1 g/cm3

Boiling Point924.9±65.0 °C at 760 mmHg

Melting Point

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symbol6.1(b)

Signal WordWarning

Cat. No.: 2A-9010648 Purity: ≥98 (HPLC)%
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Quality Control of [ 116355-83-0 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number116355-83-0
Catalog No.2A-9010648
Chinese Name伏马毒素 B1
SynonymsFumonisin B1 from Fusarium moniliforme,Macrofusine; Fumonisin B1; FB1
Molecular FormulaC34H59NO15
Molecular Weight721.83
Purity≥98 (HPLC)
Density1.3±0.1 g/cm3
Boiling Point924.9±65.0 °C at 760 mmHg
Appearancepowder
Storage ConditionSealed, stored at 2ºC -8ºC
PackagingIII
ApplicationFumonisin B1 is a mycotoxin produced by Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase), disrupting de novo sphingolipid biosynthesis. Fum
HTC29221990
PubChem ID24894752
MDL NumberMFCD27977580
SMILESCCCC[C@@H](C)[C@@H](OC(=O)C[C@@H](CC(O)=O)C(O)=O)[C@H](C[C@@H](C)C[C@H](O)CCCC[C@@H](O)C[C@H](O)[C@H](C)N)OC(=O)C[C@@H](CC(O)=O)C(O)=O
InChI1S/C34H59NO15/c1-5-6-9-20(3)32(50-31(44)17-23(34(47)48)15-29(41)42)27(49-30(43)16-22(33(45)46)14-28(39)40)13-19(2)12-24(36)10-7-8-11-25(37)18-26(38)21(4)35/h19-27,32,36-38H,5-18,35H2,1-4H3,(H,39,40)(H,41,42)(H,45,46)(H,47,48)/t19-,20+,21-,22+,23+,24+,25+,26-,27-,32+/m0/s1
InChI KeyUVBUBMSSQKOIBE-DSLOAKGESA-N
NACRES CodeNA.32
UNSPSC12352200
Hazard Symbols6.1(b)
MSDSmsds/10648_1_116355_83_0.pdf
BioactivityFumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin[1][2]. Related Catalog Research Areas >> Infection Signaling Pathways >> Others >> Others Target Sphingosine N-acyltransferase[2] In Vitro Fumonisin B1 alters the gene expression and signal transduction pathways in monkey kidney cells[3]. Fumonisin B1 increases the initial disruption of sphingolipid metabolism and the accumulation of sphinganine in LLC-PK1 kidney cells, causes DNA damage of apoptotic type in rat astrocytes[3]. References [1]. Henry MH, et al. The toxicity of fumonisin B1, B2, and B3, individually and in combination, in chicken embryos. Poult Sci. 2001 Apr;80(4):401-7. [2]. Shephard GS, et al. Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing Fusarium moniliforme culture material. Toxicon. 1996 May;34(5):527-34. [3]. Wang SK, et al. Effect of fumonisin B₁ on the cell cycle of normal human liver cells. Mol Med Rep. 2013 Jun;7(6):1970-6. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 924.9±65.0 °C at 760 mmHg Molecular Formula C34H59NO15 Molecular Weight 721.830 Flash Point 513.2±34.3 °C Exact Mass 721.388489 PSA 288.51000 LogP 2.20 Vapour Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.528 InChIKey UVBUBMSSQKOIBE-DSLOAKGESA-N SMILES CCCCC(C)C(OC(=O)CC(CC(=O)O)C(=O)O)C(CC(C)CC(O)CCCCC(O)CC(O)C(C)N)OC(=O)CC(CC(=O)O)C(=O)O
Use ofFumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin[1][2]. Properties Articles80 Name fumonisin B1 Synonym More Synonyms FB1 Biological Activity Description Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin[1][2]. Related Catalog Research Areas >> Infection Signaling Pathways >> Others >> Others Sphingosine N-acyltransferase[2] In Vitro Fumonisin B1 alters the gene expression and signal transduction pathways in monkey kidney cells[3]. Fumonisin B1 increases the initial disruption of sphingolipid metabolism and the accumulation of sphinganine in LLC-PK1 kidney cells, causes DNA damage of apoptotic type in rat astrocytes[3]. References [1]. Henry MH, et al. The toxicity of fumonisin B1, B2, and B3, individually and in combination, in chicken embryos. Poult Sci. 2001 Apr;80(4):401-7. [2]. Shephard GS, et al. Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing Fusarium moniliforme culture material. Toxicon. 1996 May;34(5):527-34. [3]. Wang SK, et al. Effect of fumonisin B₁ on the cell cycle of normal human liver cells. Mol Med Rep. 2013 Jun;7(6):1970-6. Chemical & Physical Properties Molecular Formula C34H59NO15 Exact Mass 721.388489 PSA 288.51000 Index of Refraction 1.528 InChIKey UVBUBMSSQKOIBE-DSLOAKGESA-N SMILES CCCCC(C)C(OC(=O)CC(CC(=O)O)C(=O)O)C(CC(C)CC(O)CCCCC(O)CC(O)C(C)N)OC(=O)CC(CC(=O)O)C(=O)O
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip.
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