| Chemical & Physical Properties | |
|---|---|
| CAS Number | 13189-98-5 |
| Catalog No. | 2A-9010645 |
| Chinese Name | 福多司坦 |
| Synonyms | FUDESTEINE; fudosteine; S-(3-Hydroxypropyl)-L-cysteine; MFCD00899873 |
| Molecular Formula | C6H13O3N1S1 |
| Molecular Weight | 179.24 |
| Purity | 99 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 354.5±42.0 °C at 760 mmHg |
| Melting Point | 210.9-212.5ºC |
| Appearance | off-white crystal |
| Storage Condition | -20°C Freezer |
| Application | Fudosteine is a mucus active agent and inhibitor of mucin hypersecretion by MUC5AC. |
| MDL Number | MFCD00899873 |
| SMILES | NC(CSCCCO)C(=O)O |
| InChI | InChI=1S/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5,8H,1-4,7H2,(H,9,10)/t5-/m0/s1 |
| InChI Key | KINWYTAUPKOPCQ-YFKPBYRVSA-N |
| MSDS | msds/10645_1_13189_98_5.pdf |
| Bioactivity | Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.Target: OthersFudosteine is a cysteine derivative that is used as an expectorant in chronic bronchial inflammatory disorders. The administration of fudosteine during the challenge with ovalbumin prevented the development of airway hyperresponsiveness and accumulation of lymphocytes in the airways. Eotaxin, IL-4, and TGF-β levels and the relative intensity of matrix metalloproteinase-2 and matrix metalloproteinase-9 (MMP-2 and MMP-9) in BAL fluid were reduced by the fudosteine treatment; however, the number of eosinophils in BAL fluid and serum IgE levels did not change. The expression of TGF-β, the development of goblet cell hyperplasia, subepithelial collagenization, and basement membrane thickening were also reduced by the fudosteine treatment [1]. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of fudosteine are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro [2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Ueno-Iio, T., et al., Effect of fudosteine, a cysteine derivative, on airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma. Life Sci, 2013. 92(20-21): p. 1015-23. [2]. Rhee, C.K., et al., Effect of fudosteine on mucin production. Eur Respir J, 2008. 32(5): p. 1195-202. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 354.5±42.0 °C at 760 mmHg Melting Point 210.9-212.5ºC Molecular Formula C6H13NO3S Molecular Weight 179.237 Flash Point 168.2±27.9 °C Exact Mass 179.061615 PSA 108.85000 LogP -0.10 Vapour Pressure 0.0±1.8 mmHg at 25°C Index of Refraction 1.558 InChIKey KINWYTAUPKOPCQ-YFKPBYRVSA-N SMILES NC(CSCCCO)C(=O)O Storage condition -20°C Freezer |
| Use of | Properties Name Fudosteine Synonym More Synonyms Fudosteine Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Ueno-Iio, T., et al., Effect of fudosteine, a cysteine derivative, on airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma. Life Sci, 2013. 92(20-21): p. 1015-23. [2]. Rhee, C.K., et al., Effect of fudosteine on mucin production. Eur Respir J, 2008. 32(5): p. 1195-202. Chemical & Physical Properties Molecular Formula C6H13NO3S Exact Mass 179.061615 PSA 108.85000 LogP -0.10 Index of Refraction 1.558 InChIKey KINWYTAUPKOPCQ-YFKPBYRVSA-N SMILES NC(CSCCCO)C(=O)O |
| Transport Info | Product Name: Fudosteine |
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