CAS Number559-74-0
SynonymsD:A-Friedooleanan-3-one; Einecs 209-205-1; 3-oxofriedelane; 3-friedelanone; Friedeline; FRIEDELAN-3-ONE; Friedelin; friedelane-3-one
Molecular FormulaC30H50O
Molecular Weight426.72
Purity≥95.0 (HPLC)%
Density1.0±0.1 g/cm3
Boiling Point477.2±13.0 °C at 760 mmHg
Melting Point262-265 °C (lit.)
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 559-74-0 |
| Catalog No. | 2A-9010633 |
| Chinese Name | 无羁萜，木栓酮 |
| Synonyms | D:A-Friedooleanan-3-one; Einecs 209-205-1; 3-oxofriedelane; 3-friedelanone; Friedeline; FRIEDELAN-3-ONE; Friedelin; friedelane-3-one |
| Molecular Formula | C30H50O |
| Molecular Weight | 426.72 |
| Purity | ≥95.0 (HPLC) |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 477.2±13.0 °C at 760 mmHg |
| Melting Point | 262-265 °C (lit.) |
| Appearance | solid |
| Storage Condition | 2-8℃ |
| Application | Friedelin is isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a non-competitive inhibitor of CYP3A4 with IC50 and Ki values of 10.79 μM and 6.16 μM, respectively. Friedelin is als |
| MDL Number | MFCD00017296 |
| SMILES | C[C@H]1C(=O)CC[C@@H]2[C@]1(C)CC[C@H]3[C@@]2(C)CC[C@@]4(C)[C@@H]5CC(C)(C)CC[C@]5(C)CC[C@]34C |
| InChI | 1S/C30H50O/c1-20-21(31)9-10-22-27(20,5)12-11-23-28(22,6)16-18-30(8)24-19-25(2,3)13-14-26(24,4)15-17-29(23,30)7/h20,22-24H,9-19H2,1-8H3/t20-,22+,23-,24+,26+,27+,28-,29+,30-/m0/s1 |
| InChI Key | OFMXGFHWLZPCFL-SVRPQWSVSA-N |
| Beilstein/REAXYS | 1916451 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/10633_1_559_74_0.pdf |
| Bioactivity | Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a noncompetitive inhibitor of CYP3A4 with IC50 and Kivalues of 10.79 μM and 6.16 μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC50 and Ki values of 22.54 μM and 18.02 μM, respectively[1]. Related Catalog Research Areas >> Others Target IC50: 10.79 μM (CYP3A4), 22.54 μM (CYP2E1); Ki: 6.16 μM(CYP3A4), 18.02 μM(CYP2E1)[1] References [1]. Wei J, et al. In vitro inhibitory effects of Friedelin on human liver cytochrome P450 enzymes. Pharm Biol. 2018 Dec;56(1):363-367. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 477.2±13.0 °C at 760 mmHg Melting Point 262-265ºC(lit.) Molecular Formula C30H50O Molecular Weight 426.717 Flash Point 233.9±12.1 °C Exact Mass 426.386169 PSA 17.07000 LogP 10.87 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.503 InChIKey OFMXGFHWLZPCFL-SVRPQWSVSA-N SMILES CC1C(=O)CCC2C1(C)CCC1C2(C)CCC2(C)C3CC(C)(C)CCC3(C)CCC12C Storage condition 2-8℃ |
| Use of | Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a noncompetitive inhibitor of CYP3A4 with IC50 and Kivalues of 10.79 μM and 6.16 μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC50 and Ki values of 22.54 μM and 18.02 μM, respectively[1]. Properties Name friedelin Synonym More Synonyms Friedelin Biological Activity Description Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a noncompetitive inhibitor of CYP3A4 with IC50 and Kivalues of 10.79 μM and 6.16 μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC50 and Ki values of 22.54 μM and 18.02 μM, respectively[1]. Related Catalog Research Areas >> Others IC50: 10.79 μM (CYP3A4), 22.54 μM (CYP2E1); Ki: 6.16 μM(CYP3A4), 18.02 μM(CYP2E1)[1] References [1]. Wei J, et al. In vitro inhibitory effects of Friedelin on human liver cytochrome P450 enzymes. Pharm Biol. 2018 Dec;56(1):363-367. Chemical & Physical Properties Molecular Formula C30H50O Exact Mass 426.386169 PSA 17.07000 LogP 10.87 Index of Refraction 1.503 InChIKey OFMXGFHWLZPCFL-SVRPQWSVSA-N Storage condition 2-8℃ |
| Transport Info | Product Name: Suberone |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Fortimicin | 55779-06-1 | 2A-9010611 |
| Fotemustine | 92118-27-9 | 2A-9010626 |
| Fradafiban | 148396-36-5 | 2A-9010627 |
| Fraxidin | 525-21-3 | 2A-9010630 |
| Frentizole | 26130-02-9 | 2A-9010632 |
| Fronepidil | 79700-63-3 | 2A-9010634 |
| Fropenem | 106560-14-9 | 2A-9010635 |
| Fructose-1,6-diphosphate magnesium salt | 2A-301720 | 2A-9010637 |
| Fructus cannabis PE | 2A-301722 | 2A-9010639 |
| Fructus Corni Extract | 2A-301723 | 2A-9010640 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS