| Chemical & Physical Properties | |
|---|---|
| CAS Number | 136468-36-5 |
| Catalog No. | 2A-9010609 |
| Chinese Name | 福罗帕泛 |
| Synonyms | MFCD00904759 |
| Molecular Formula | C28H40N4S |
| Molecular Weight | 464.71 |
| Purity | ≥98 (HPLC) |
| Density | 1.065g/cm3 |
| Boiling Point | 571.6ºC at 760mmHg |
| Appearance | powder |
| Storage Condition | -20°C |
| Application | Foropafant (SR27417) is a highly potent, competitive, selective, orally available platelet-activating factor (PAF) receptor antagonist that inhibits the binding of [3H]PAF to its receptor with a Ki of |
| PubChem ID | 329825543 |
| MDL Number | MFCD00904759 |
| SMILES | CC(C)c1cc(C(C)C)c(-c2csc(n2)N(CCN(C)C)Cc3cccnc3)c(c1)C(C)C |
| InChI | 1S/C28H40N4S/c1-19(2)23-14-24(20(3)4)27(25(15-23)21(5)6)26-18-33-28(30-26)32(13-12-31(7)8)17-22-10-9-11-29-16-22/h9-11,14-16,18-21H,12-13,17H2,1-8H3 |
| InChI Key | VVBFISAUNSXQGZ-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/10609_1_136468_36_5.pdf |
| Bioactivity | Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Target Ki: 57 pM ([3H]PAF binding)[1] References [1]. Herbert JM, et al. Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259(1):44-51. Chemical & Physical Properties Density 1.065g/cm3 Boiling Point 571.6ºC at 760mmHg Molecular Formula C28H40N4S Molecular Weight 464.70900 Flash Point 299.5ºC Exact Mass 464.29700 PSA 60.50000 LogP 7.14350 Vapour Pressure 4.49E-13mmHg at 25°C Index of Refraction 1.575 InChIKey VVBFISAUNSXQGZ-UHFFFAOYSA-N SMILES CC(C)c1cc(C(C)C)c(-c2csc(N(CCN(C)C)Cc3cccnc3)n2)c(C(C)C)c1 Storage condition -20°C |
| Use of | Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1]. Properties Articles23 Name N,N-dimethyl-N'-(pyridin-3-ylmethyl)-N'-[4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl]ethane-1,2-diamine Synonym More Synonyms Foropafant Biological Activity Description Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Ki: 57 pM ([3H]PAF binding)[1] References [1]. Herbert JM, et al. Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259(1):44-51. Chemical & Physical Properties Molecular Formula C28H40N4S Exact Mass 464.29700 PSA 60.50000 LogP 7.14350 Index of Refraction 1.575 InChIKey VVBFISAUNSXQGZ-UHFFFAOYSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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