CAS Number104227-87-4
Synonyms2-(2-(2-Amino-9H-purin-9-yl)ethyl)propane-1,3-diyl diacetate; acétate de 2-[(acétyloxy)méthyl]-4-(2-amino-9H-purin-9-yl)butyle; 2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate ester; 2-(Acetoxymethyl)-4-(2-amino-9H-purin-9-yl)butyl acetate; 2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol Diacetate; Famciclovir; Amciclovir; Famciclover; 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate (non-preferred name); 2-[(Acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butylacetat; FaMtrex; Famvir; FaMciclovir API; famcyclovir; FCV; MFCD00866964; 1,3-Propanediol, 2-[2-(2-amino-9H-purin-9-yl)ethyl]-, diacetate (ester); 2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol Diacetate (Ester); 9-[4-Acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine; FaMcivir
Molecular FormulaC14H19N5O4
Molecular Weight321.33
Purity98%
Density1.4±0.1 g/cm3
Boiling Point550.2±60.0 °C at 760 mmHg
Melting Point102-104°C
Appearanceoff-white powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 104227-87-4 |
| Catalog No. | 2A-9010443 |
| Chinese Name | 泛昔洛韦 |
| Synonyms | 2-(2-(2-Amino-9H-purin-9-yl)ethyl)propane-1,3-diyl diacetate; acétate de 2-[(acétyloxy)méthyl]-4-(2-amino-9H-purin-9-yl)butyle; 2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate ester; 2-(Acetoxymethyl)-4-(2-amino-9H-purin-9-yl)butyl acetate; 2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol Diacetate; Famciclovir; Amciclovir; Famciclover; 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate (non-preferred name); 2-[(Acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butylacetat; FaMtrex; Famvir; FaMciclovir API; famcyclovir; FCV; MFCD00866964; 1,3-Propanediol, 2-[2-(2-amino-9H-purin-9-yl)ethyl]-, diacetate (ester); 2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol Diacetate (Ester); 9-[4-Acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine; FaMcivir |
| Molecular Formula | C14H19N5O4 |
| Molecular Weight | 321.33 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 550.2±60.0 °C at 760 mmHg |
| Melting Point | 102-104°C |
| Appearance | off-white powder |
| Water Solubility | Insoluble |
| Storage Condition | -20°C Freezer |
| Application | Famciclovir (BRL 42810) is a guanine analog with anti-herpes virus activity. |
| HTC | 2942000000 |
| PubChem ID | 329823560 |
| MDL Number | MFCD00866964 |
| SMILES | CC(=O)OCC(CCn1cnc2cnc(N)nc12)COC(C)=O |
| InChI | 1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18) |
| InChI Key | GGXKWVWZWMLJEH-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/10443_1_104227_87_4.pdf |
| Bioactivity | Famciclovir(BRL 42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.IC50 Value: Refer to penciclovirTarget: HSVFamciclovir is the diacetyl 6-deoxy analog of the active antiviral compound penciclovir with potential use in the treatment of infections caused by the herpes family of viruses [1]. Famciclovir, a synthetic acyclic guanine derivative, is a prodrug which, after oral administration, is rapidly metabolised to the highly bioavailable antiviral compound penciclovir [2].in vitro: Famciclovir induced rapid, dose-dependent suppression of viral replication and reduction in alanine aminotransferase (ALT), with greatest efficacy in the 500-mg tid treatment group. HBV DNA reduction was maintained throughout the treatment period. ALT also steadily declined during the treatment period [3]. in vivo: In rat, following dosing at 40 mg/kg, famciclovir was rapidly and extensively metabolized to the active antiviral compound penciclovir, which reached peak concentrations in the plasma (mean 3.5 micrograms/ml) at 0.5 h [4]. Necrotic hepatitis was significantly (p < 0.01) reduced by treatment with FCV, VACV and ACV at a dose of 50 mg/kg per day divided into 3 doses. No significant effect was achieved with BVDU at 200 mg/kg per day. Treatment with FCV at 50 mg/kg per day, ACV at 100 mg/kg per day, and VACV at 200 mg/kg per day significantly (p < 0.001) decreased mortality in mice [5].Clinical trial: Famciclovir Pediatric Formulation In Children 1 to 12 Years Of Age With Herpes Simplex Infection. Phage3 Related Catalog Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection References [1]. Harrell AW, Wheeler SM, Pennick M, Evidence that famciclovir (BRL 42810) and its associated metabolites do not inhibit the 6 beta-hydroxylation of testosterone in human liver microsomes. Drug Metab Dispos. 1993 Jan-Feb;21(1):18-23. [2]. Perry CM, Wagstaff AJ. Famciclovir. A review of its pharmacological properties and therapeutic efficacy in herpesvirus infections. Drugs. 1995 Aug;50(2):396-415. [3]. Trépo C, Jezek P, Atkinson G, Famciclovir in chronic hepatitis B: results of a dose-finding study. J Hepatol. 2000 Jun;32(6):1011-8. [4]. Filer CW, Ramji JV, Allen GD, Metabolic and pharmacokinetic studies following oral administration of famciclovir to the rat and dog. Xenobiotica. 1995 May;25(5):477-90. [5]. Wutzler P, Ulbricht A, F?rber I. Antiviral efficacies of famciclovir, valaciclovir, and brivudin in disseminated herpes simplex virus type 1 infection in mice. Intervirology. 1997;40(1):15-21. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 550.2±60.0 °C at 760 mmHg Melting Point 102-104°C Molecular Formula C14H19N5O4 Molecular Weight 321.332 Flash Point 286.6±32.9 °C Exact Mass 321.143707 PSA 122.22000 LogP -0.67 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.628 InChIKey GGXKWVWZWMLJEH-UHFFFAOYSA-N SMILES CC(=O)OCC(CCn1cnc2cnc(N)nc21)COC(C)=O Storage condition -20°C Freezer |
| Use of | Properties Articles49 Name famciclovir Synonym More Synonyms Famciclovir Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection References [1]. Harrell AW, Wheeler SM, Pennick M, Evidence that famciclovir (BRL 42810) and its associated metabolites do not inhibit the 6 beta-hydroxylation of testosterone in human liver microsomes. Drug Metab Dispos. 1993 Jan-Feb;21(1):18-23. [2]. Perry CM, Wagstaff AJ. Famciclovir. A review of its pharmacological properties and therapeutic efficacy in herpesvirus infections. Drugs. 1995 Aug;50(2):396-415. [3]. Trépo C, Jezek P, Atkinson G, Famciclovir in chronic hepatitis B: results of a dose-finding study. J Hepatol. 2000 Jun;32(6):1011-8. [4]. Filer CW, Ramji JV, Allen GD, Metabolic and pharmacokinetic studies following oral administration of famciclovir to the rat and dog. Xenobiotica. 1995 May;25(5):477-90. [5]. Wutzler P, Ulbricht A, F?rber I. Antiviral efficacies of famciclovir, valaciclovir, and brivudin in disseminated herpes simplex virus type 1 infection in mice. Intervirology. 1997;40(1):15-21. Chemical & Physical Properties Molecular Formula C14H19N5O4 Exact Mass 321.143707 PSA 122.22000 LogP -0.67 Index of Refraction 1.628 InChIKey GGXKWVWZWMLJEH-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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