CAS Number163222-33-1
SynonymsEzetimide; Zetia; EzitiMibeEzetiMibeC24H21F2N03; Ezetrol; Int; ezetimibe; EzetiMib; MFCD00937872
Molecular FormulaC24H21F2NO3
Molecular Weight409.43
Purity99%
Density1.3±0.1 g/cm3
Boiling Point654.9±55.0 °C at 760 mmHg
Melting Point164-166℃
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 163222-33-1 |
| Catalog No. | 2A-9010442 |
| Chinese Name | 依泽替米贝 |
| Synonyms | Ezetimide; Zetia; EzitiMibeEzetiMibeC24H21F2N03; Ezetrol; Int; ezetimibe; EzetiMib; MFCD00937872 |
| Molecular Formula | C24H21F2NO3 |
| Molecular Weight | 409.43 |
| Purity | 99 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 654.9±55.0 °C at 760 mmHg |
| Melting Point | 164-166℃ |
| Appearance | powder |
| Water Solubility | Water solubility: insoluble; water solubility: 4.4 |
| Storage Condition | -20?C Freezer |
| Application | Ezetimibe (SCH 58235) is an NPC1L1 inhibitor and a potent Nrf2 activator, and Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. |
| HTC | 2934999090 |
| MDL Number | MFCD00937872 |
| SMILES | FC(C=C1)=CC=C1N([C@H](C2=CC=C(O)C=C2)[C@H]3CC[C@H](O)C4=CC=C(F)C=C4)C3=O |
| InChI | 1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1 |
| InChI Key | OLNTVTPDXPETLC-XPWALMASSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/10442_1_163222_33_1.pdf |
| Use of | Properties Name ezetimibe Synonym More Synonyms Ezetimibe Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Cardiovascular Disease In Vivo Administration of Ezetimibe (Eze) reduces the liver weights of mice fed the methionine- and choline-deficient (MCD) diet. This is consistent with the beneficial effects of Ezetimibe on hepatic steatosis. Liver histology shows pronounced multiple macrovesicular fat droplets in mice on the MCD diet, but Ezetimibe treatment markedly decreases the number and size of those droplets. Furthermore, hepatic fibrosis in mice fed the MCD diet is significantly attenuated by Ezetimibe[1]. Blood and liver lipid levels including TG, free fatty acids (FFA), and total cholesterol (TC) are significantly decreased in Ezetimibe-treated OLETF rats. Moreover, OLETF rats show higher serum levels of glucose, insulin, HOMA-IR, TG, FFA, and TC than LETF animals, which are significantly reduced by Ezetimibe. In addition, histological analysis indicated that OLETF control rats showed larger lipid droplets in hepatocytes than age-matched LETO controls, which are attenuated by administration of Ezetimibe[2]. References [2]. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63. Chemical & Physical Properties Molecular Formula C24H21F2NO3 Exact Mass 409.148956 PSA 60.77000 Index of Refraction 1.624 InChIKey OLNTVTPDXPETLC-XPWALMASSA-N Storage condition -20?C Freezer Safety Information Safety Phrases 26-36 RIDADR NONH for all modes of transport HS Code 2934999090 Synthetic Route Ezetimibe Keton... 191330-56-0 163222-33-1 4'-O-Benzyl... 163222-32-0 163222-33-1 Literature: Sniezek, Marcin; Stecko, Sebastian; Panfil, Irma; Furman, Bartlomiej; Chmielewski, Marek Journal of Organic Chemistry, 2013 , vol. 78, # 14 p. 7048 - 7057 benzyl (4-((1S,... 1197343-05-7 163222-33-1 Precursor & DownStream Precursor 7 CAS#:191330-56-0 Ezetimibe Ketone CAS#:163222-32-0 4'-O-Benzyloxy ... CAS#:190595-65-4 (3R,4S)-4-[4-(B... CAS#:1042722-68-8 (3R,4S)-1-(4-fl... DownStream 1 CAS#:163380-20-9 [4-[(2S,3R)-3-[... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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