CAS Number107724-20-9
SynonymsInspra; EplerenoneC24H3006; 9,11a-Epoxy-17-hydroxy-3-oxo-17a-pregn-4-ene-7a,21-dicarboxylic Acid g-Lactone Methyl Ester; Elperenone; Epleremone; epoxymexrenone; Eplerenone; 9,11α-Epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic Acid γ-Lactone Methyl Ester; EPLERINONE
Molecular FormulaC24H30O6
Molecular Weight414.49
Purity98%
Density1.3±0.1 g/cm3
Boiling Point597.9±50.0 °C at 760 mmHg
Melting Point241-243ºC
Appearancewhite solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 107724-20-9 |
| Catalog No. | 2A-9010351 |
| Chinese Name | 依普利酮 |
| Synonyms | Inspra; EplerenoneC24H3006; 9,11a-Epoxy-17-hydroxy-3-oxo-17a-pregn-4-ene-7a,21-dicarboxylic Acid g-Lactone Methyl Ester; Elperenone; Epleremone; epoxymexrenone; Eplerenone; 9,11α-Epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic Acid γ-Lactone Methyl Ester; EPLERINONE |
| Molecular Formula | C24H30O6 |
| Molecular Weight | 414.49 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 597.9±50.0 °C at 760 mmHg |
| Melting Point | 241-243ºC |
| Appearance | white solid |
| Water Solubility | Water solubility: virtually insoluble; soluble in: |
| Storage Condition | 0-10°C; avoid heating |
| Application | Eplerenone is an aldosterone antagonist with an IC50 of 360nM. |
| HTC | 29322090 |
| SMILES | O1[C@]32[C@H]1C[C@@]4([C@@]6(OC(=O)CC6)CC[C@H]4[C@@H]3[C@@H](CC5=CC(=O)CC[C@@]52C)C(=O)OC)C |
| InChI | 1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1 |
| InChI Key | JUKPWJGBANNWMW-VWBFHTRKSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/10351_1_107724_20_9.pdf |
| Bioactivity | Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM.Target: Mineralocorticoid ReceptorEplerenone is a selective mineralocorticoid receptor antagonist, which has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors [1]. Benefits of eplerenone therapy over placebo were also observed in several secondary outcomes, including: death from any cause or hospitalization for HF; death from any cause; hospitalization for any reason; or hospitalization for HF [2]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor Research Areas >> Cardiovascular Disease References [1]. Chatterjee, S., et al., Eplerenone is not superior to older and less expensive aldosterone antagonists. Am J Med, 2012. 125(8): p. 817-25. [2]. Dhillon, S., Eplerenone: a review of its use in patients with chronic systolic heart failure and mild symptoms. Drugs, 2013. 73(13): p. 1451-62. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 597.9±50.0 °C at 760 mmHg Melting Point 241-243ºC Molecular Formula C24H30O6 Molecular Weight 414.491 Flash Point 259.5±30.2 °C Exact Mass 414.204254 PSA 82.20000 LogP 1.05 Vapour Pressure 0.0±1.7 mmHg at 25°C Index of Refraction 1.587 InChIKey JUKPWJGBANNWMW-AORFUQRWSA-N SMILES COC(=O)C1CC2=CC(=O)CCC2(C)C23OC2CC2(C)C(CCC24CCC(=O)O4)C13 |
| Use of | Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM.Target: Mineralocorticoid ReceptorEplerenone is a selective mineralocorticoid receptor antagonist, which has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors [1]. Benefits of eplerenone therapy over placebo were also observed in several secondary outcomes, including: death from any cause or hospitalization for HF; death from any cause; hospitalization for any reason; or hospitalization for HF [2]. Properties Articles15 Name eplerenone Synonym More Synonyms Eplerenone Biological Activity Description Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM.Target: Mineralocorticoid ReceptorEplerenone is a selective mineralocorticoid receptor antagonist, which has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors [1]. Benefits of eplerenone therapy over placebo were also observed in several secondary outcomes, including: death from any cause or hospitalization for HF; death from any cause; hospitalization for any reason; or hospitalization for HF [2]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor Research Areas >> Cardiovascular Disease References [1]. Chatterjee, S., et al., Eplerenone is not superior to older and less expensive aldosterone antagonists. Am J Med, 2012. 125(8): p. 817-25. [2]. Dhillon, S., Eplerenone: a review of its use in patients with chronic systolic heart failure and mild symptoms. Drugs, 2013. 73(13): p. 1451-62. Chemical & Physical Properties Molecular Formula C24H30O6 Exact Mass 414.204254 PSA 82.20000 Index of Refraction 1.587 InChIKey JUKPWJGBANNWMW-AORFUQRWSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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