CAS Number80012-43-7
SynonymsEPINASTINE BASE; 9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3-amine; Flurinol(R); 3-amino-9,13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepine; Epinastine; 3-Amino-9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine; MFCD00865648
Molecular FormulaC16H15N3
Molecular Weight249.32
Purity98%
Density1.32 g/cm3
Boiling Point428ºC at 760 mmHg
Melting Point270ºC
AppearanceWhite to yellow crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 80012-43-7 |
| Catalog No. | 2A-9010346 |
| Chinese Name | 依匹斯汀 |
| Synonyms | EPINASTINE BASE; 9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3-amine; Flurinol(R); 3-amino-9,13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepine; Epinastine; 3-Amino-9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine; MFCD00865648 |
| Molecular Formula | C16H15N3 |
| Molecular Weight | 249.32 |
| Purity | 98 |
| Density | 1.32 g/cm3 |
| Boiling Point | 428ºC at 760 mmHg |
| Melting Point | 270ºC |
| Appearance | White to yellow crystalline powder |
| Storage Condition | 2-8℃ |
| Application | Epinastine (WAL801) is an antihistamine and mast cell stabilizer that can act on allergic conjunctivitis. |
| MDL Number | MFCD00865648 |
| SMILES | NC1=NCC2c3ccccc3Cc3ccccc3N12 |
| InChI | InChI=1S/C16H15N3.ClH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H |
| InChI Key | WHWZLSFABNNENI-UHFFFAOYSA-N |
| MSDS | msds/10346_1_80012_43_7.pdf |
| Bioactivity | Epinastine(WAL801) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.Target: Histamine ReceptorEpinastine shows a high affinity to H1-receptors in receptor binding studies in the guinea pig ileum. Epinastine inhibits histamine-induced reactions in the skin or the lung of rats, dogs and guinea pigs [1]. Epinastine is able to displace specific [3H]NC-5Z binding at low concentrations in the locust nervous tissue. Epinastine binds to the honey bees neuronal octopamine receptor with Ki of 1.1 nM. Epinastine antagonises octopamine-induced cAMP formation in the insect brain [2]. Epinastine causes an inhibition of histamine release from rat peritoneal mast cells induced by both antigen-antibody reaction and compound 48/80. Epinastine is similarly effective in inhibiting compound 48/80-induced histamine release not only from isolated rat peritoneal mast cells but also from rat mesenterial pieces. Epinastine is effective in inhibiting not only Ca2+ uptake into lung mast cells in actively sensitized guinea pigs but also Ca2+ release from the intracellular Ca store of rat peritoneal mast cells exposed to both compound 48/80 and substance P [3]. Epinastine shows a dose- and time-dependent suppressive effect on IL-8, one of the chemokines for eosinophils, released from eosinophils isolated from atopic diseases [4]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. Fugner, A., et al., In vitro and in vivo studies of the non-sedating antihistamine epinastine. Arzneimittelforschung, 1988. 38(10): p. 1446-53. [2]. Roeder, T., J. Degen, and M. Gewecke, Epinastine, a highly specific antagonist of insect neuronal octopamine receptors. Eur J Pharmacol, 1998. 349(2-3): p. 171-7. [3]. Kamei, C., et al., Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (I). Elucidation of the mechanism for histamine release inhibition. Immunopharmacol Immunotoxicol, 1992. 14(1-2): p. 191-205. [4]. Kohyama, T., et al., A novel antiallergic drug epinastine inhibits IL-8 release from human eosinophils. Biochem Biophys Res Commun, 1997. 230(1): p. 125-8. Chemical & Physical Properties Density 1.32 g/cm3 Boiling Point 428ºC at 760 mmHg Melting Point 270ºC Molecular Formula C16H15N3 Molecular Weight 249.31000 Flash Point 212.7ºC Exact Mass 249.12700 PSA 41.62000 LogP 2.66770 Index of Refraction 1.727 InChIKey WHWZLSFABNNENI-UHFFFAOYSA-N SMILES NC1=NCC2c3ccccc3Cc3ccccc3N12 Storage condition 2-8℃ |
| Use of | Properties Name epinastine Synonym More Synonyms Epinastine Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. Fugner, A., et al., In vitro and in vivo studies of the non-sedating antihistamine epinastine. Arzneimittelforschung, 1988. 38(10): p. 1446-53. [2]. Roeder, T., J. Degen, and M. Gewecke, Epinastine, a highly specific antagonist of insect neuronal octopamine receptors. Eur J Pharmacol, 1998. 349(2-3): p. 171-7. [4]. Kohyama, T., et al., A novel antiallergic drug epinastine inhibits IL-8 release from human eosinophils. Biochem Biophys Res Commun, 1997. 230(1): p. 125-8. Chemical & Physical Properties Molecular Formula C16H15N3 Exact Mass 249.12700 PSA 41.62000 LogP 2.66770 Index of Refraction 1.727 InChIKey WHWZLSFABNNENI-UHFFFAOYSA-N Storage condition 2-8℃ |
| Transport Info | Product name: 9,13B-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine-3-amine |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Eperisone | 64840-90-0 | 2A-9010341 |
| Eperisone hydrochloride | 56839-43-1 | 2A-9010342 |
| Epicainide | 66304-03-8 | 2A-9010343 |
| Epicillin | 26774-90-3 | 2A-9010344 |
| Epimedium P.E. | 108929-04-0 | 2A-9010345 |
| Epinastine hydrochloride | 80012-44-8 | 2A-9010347 |
| Eplerenone | 107724-20-9 | 2A-9010351 |
| Epoprostenol | 61849-14-7 | 2A-9010352 |
| Epoxiconazole | 135319-73-2 | 2A-9010353 |
| Eprazinone | 10402-90-1 | 2A-9010354 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS