CAS Number62013-04-1
SynonymsNoriclan; Dynabac; Dirythromycin; 4,16-Dioxa-14-azabicyclo[11.3.1]heptadecan-5-one; MFCD00865041; ASE 136; Dirithomycin; Valodin; Dirithromycin; Antibiotic AS-E 136
Molecular FormulaC42H78N2O14
Molecular Weight835.07
Purity98%
Density1.2±0.1 g/cm3
Boiling Point871.8±65.0 °C at 760 mmHg
Melting Point185 - 189ºC
Appearancecrystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 62013-04-1 |
| Catalog No. | 2A-9010204 |
| Chinese Name | 地红霉素 |
| Synonyms | Noriclan; Dynabac; Dirythromycin; 4,16-Dioxa-14-azabicyclo[11.3.1]heptadecan-5-one; MFCD00865041; ASE 136; Dirithomycin; Valodin; Dirithromycin; Antibiotic AS-E 136 |
| Molecular Formula | C42H78N2O14 |
| Molecular Weight | 835.07 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 871.8±65.0 °C at 760 mmHg |
| Melting Point | 185 - 189ºC |
| Appearance | crystal |
| Storage Condition | -20°C |
| Application | Dirithromycin (LY 237216) is a macrolide glycopeptide antibiotic that can bind to the 50S subunit of the 70S bacterial ribosome. |
| HTC | 29419000 |
| PubChem ID | 329798757 |
| MDL Number | MFCD00865041 |
| SMILES | CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C4N[C@@H](COCCOC)OC([C@H]4C)[C@]1(C)O |
| InChI | 1S/C42H78N2O14/c1-15-29-42(10,49)37-24(4)32(43-30(56-37)21-52-17-16-50-13)22(2)19-40(8,48)36(58-39-33(45)28(44(11)12)18-23(3)53-39)25(5)34(26(6)38(47)55-29)57-31-20-41(9,51-14)35(46)27(7)54-31/h22-37,39,43,45-46,48-49H,15-21H2,1-14H3/t22-,23-,24+,25+,26-,27+,28+,29-,30-,31+,32+,33-,34+,35+,36-,37-,39+,40-,41+,42-/m1/s1 |
| InChI Key | WLOHNSSYAXHWNR-KZYCBHIHSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/10204_1_62013_04_1.pdf |
| Use of | Dirithromycin(LY 237216) is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides.Target: AntibacterialDirithromycin is a new macrolide with a spectrum and degree of in vitro antimicrobial activity similar to that of erythromycin. Compared with erythromycin, dirithromycin has a long elimination half-life enabling once-daily administration, and it also achieves a greater cellular:extracellular concentration ratio and higher concentration in some tissues. Multicentre double-blind clinical trials have shown dirithromycin to be similar in efficacy to erythromycin in the treatment of uncomplicated bacterial infections of the respiratory tract and of skin and soft tissues [1]. Dirithromycin offers some attractive pharmacokinetic properties. The long elimination half-life of dirithromycin allows once-daily dosing and higher and more prolonged tissue concentrations than are achievable with erythromycin. The spectrum of activity, adverse effect profile, clinical efficacy, and bacteriologic eradication rate of dirithromycin may be similar to those of erythromycin [2, 3]. Properties Articles33 Name dirithromycin Synonym More Synonyms Dirithromycin Biological Activity Description Dirithromycin(LY 237216) is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides.Target: AntibacterialDirithromycin is a new macrolide with a spectrum and degree of in vitro antimicrobial activity similar to that of erythromycin. Compared with erythromycin, dirithromycin has a long elimination half-life enabling once-daily administration, and it also achieves a greater cellular:extracellular concentration ratio and higher concentration in some tissues. Multicentre double-blind clinical trials have shown dirithromycin to be similar in efficacy to erythromycin in the treatment of uncomplicated bacterial infections of the respiratory tract and of skin and soft tissues [1]. Dirithromycin offers some attractive pharmacokinetic properties. The long elimination half-life of dirithromycin allows once-daily dosing and higher and more prolonged tissue concentrations than are achievable with erythromycin. The spectrum of activity, adverse effect profile, clinical efficacy, and bacteriologic eradication rate of dirithromycin may be similar to those of erythromycin [2, 3]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Brogden, R.N. and D.H. Peters, Dirithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy. Drugs, 1994. 48(4): p. 599-616. [2]. Wintermeyer, S.M., S.M. Abdel-Rahman, and M.C. Nahata, Dirithromycin: a new macrolide. Ann Pharmacother, 1996. 30(10): p. 1141-9. [3]. Sides, G.D., et al., Pharmacokinetics of dirithromycin. J Antimicrob Chemother, 1993. 31 Suppl C: p. 65-75. Chemical & Physical Properties Molecular Formula C42H78N2O14 Exact Mass 834.545288 PSA 196.33000 Index of Refraction 1.533 InChIKey ONSFRSSCKMXJCT-FKDJIJHVSA-N Safety Information Signal Word Warning Hazard Statements H317 Precautionary Statements P280 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves Hazard Codes Xn:Harmful Safety Phrases S36 RIDADR NONH for all modes of transport WGK Germany 3 HS Code 29419000 |
| Transport Info | Product Name: Dirithromycin |
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