EN
0
Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > Disopyramide phosphate
Disopyramide phosphate structure, CAS 22059-60-5

Disopyramide phosphate

CAS Number22059-60-5

Synonyms2-(1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)pyridinium phosphate; SC 7031 phosphate; Disopyramid; DISOPYRAMIDE PHOSPHATE SALT; (RS)-4-diisopropylamino-2-phenyl-2-(2-pyridyl)butyramide phosphate; Norpace; EINECS 244-756-1; Norpace Cr; DISOPYRAMIDE PHOSPHATE; Disopyramide phosphate

Molecular FormulaC21H29N3O · H3PO4

Molecular Weight437.47

Purity98%

Density

Boiling Point505.2ºC at 760 mmHg

Melting Point

Flash Point

Appearancesolid

EINECS244-756-1

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9010206 Purity: 98%
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 22059-60-5 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number22059-60-5
Catalog No.2A-9010206
Chinese Name达舒平 磷酸盐
Synonyms2-(1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)pyridinium phosphate; SC 7031 phosphate; Disopyramid; DISOPYRAMIDE PHOSPHATE SALT; (RS)-4-diisopropylamino-2-phenyl-2-(2-pyridyl)butyramide phosphate; Norpace; EINECS 244-756-1; Norpace Cr; DISOPYRAMIDE PHOSPHATE; Disopyramide phosphate
Molecular FormulaC21H29N3O · H3PO4
Molecular Weight437.47
Purity98
Boiling Point505.2ºC at 760 mmHg
Appearancesolid
Storage Condition2-8°C
ApplicationDipyramidine phosphate is a Class IA antiarrhythmic drug that is effective against ventricular and atrial arrhythmias. Diisopropylamine phosphate blocks the rapid inward sodium current in myocardium a
EINECS244-756-1
PubChem ID24277706
MDL NumberMFCD00069254
SMILESOP(O)(O)=O.CC(C)N(CCC(C(N)=O)(c1ccccc1)c2ccccn2)C(C)C
InChI1S/C21H29N3O.H3O4P/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19;1-5(2,3)4/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25);(H3,1,2,3,4)
InChI KeyCGDDQFMPGMYYQP-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard SymbolsTransport
MSDSmsds/10206_1_22059_60_5.pdf
BioactivityDisopyramide phosphate is a class IA antiarrhythmic drug with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action[1][2][3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel In Vitro HERG tail currents recorded at -40 mV following test pulses to +30 mV were inhibited in a dose-dependent fashion by Disopyramide concentrations within the clinical range (IC50=7.23 μM)[1]. References [1]. S V Jones, et al. Non-competitive Effects of Disopyramide at the Neuromuscular Junction: Evidence for Endplate Ion Channel Block. Br J Anaesth. 1987 Jun;59(6):776-83. [2]. L A Siddoway, et al. Clinical Pharmacokinetics of Disopyramide. Clin Pharmacokinet. May-Jun 1986;11(3):214-22. [3]. A A Paul, et al. Inhibition of HERG Potassium Channel Current by the Class 1a Antiarrhythmic Agent Disopyramide. Biochem Biophys Res Commun. 2001 Feb 9;280(5):1243-50. Chemical & Physical Properties Boiling Point 505.2ºC at 760 mmHg Molecular Formula C21H32N3O5P Molecular Weight 437.47000 Flash Point 259.4ºC Exact Mass 437.20800 PSA 146.79000 LogP 3.13360 Vapour Pressure 2.48E-10mmHg at 25°C InChIKey CGDDQFMPGMYYQP-UHFFFAOYSA-N SMILES CC(C)N(CCC(C(N)=O)(c1ccccc1)c1ccccn1)C(C)C.O=P(O)(O)O Storage condition 2-8°C
Use ofDisopyramide phosphate is a class IA antiarrhythmic drug with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action[1][2][3]. Properties Articles27 Name 4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide,phosphoric acid Synonym More Synonyms Disopyramid phosphate Biological Activity Description Disopyramide phosphate is a class IA antiarrhythmic drug with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action[1][2][3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel References [1]. S V Jones, et al. Non-competitive Effects of Disopyramide at the Neuromuscular Junction: Evidence for Endplate Ion Channel Block. Br J Anaesth. 1987 Jun;59(6):776-83. [2]. L A Siddoway, et al. Clinical Pharmacokinetics of Disopyramide. Clin Pharmacokinet. May-Jun 1986;11(3):214-22. [3]. A A Paul, et al. Inhibition of HERG Potassium Channel Current by the Class 1a Antiarrhythmic Agent Disopyramide. Biochem Biophys Res Commun. 2001 Feb 9;280(5):1243-50. Chemical & Physical Properties Molecular Formula C21H32N3O5P Exact Mass 437.20800 PSA 146.79000 LogP 3.13360 InChIKey CGDDQFMPGMYYQP-UHFFFAOYSA-N
Transport InfoProduct name: Purity: 97.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
Related Products in Specialty Chemicals
Diprafenone81447-80-52A-9010199
Diprenorphine14357-78-92A-9010200
Diproteverine69373-95-12A-9010201
Dirithromycin62013-04-12A-9010204
Disobutamide68284-69-52A-9010205
Disulfoton298-04-42A-9010207
Ditekiren103336-05-62A-9010208
Diuron330-54-12A-9010209
Divabuterol54592-27-72A-9010210
Divalproex sodium76584-70-82A-9010211
Browse all Specialty Chemicals products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA