CAS Number15307-81-0
SynonymsDiclofenic potassium; Potassium {2-[(2,6-dichlorophenyl)amino]phenyl}acetate; Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, potassium salt (1:1); potassium 2-(2-(2,6-dichlorophenylamino)phenyl)acetate; 2-((2,6-Dichlorophenyl)amino)benzeneacetic Acid Monopotassium Salt; Diclofenac potassium; 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid, potassium salt; Potassium [2-[(2,6-dichlorophenyl)amino]phenyl]acetate; MFCD00082254; Cataflam; CGP 45840B; CGP-45840B; 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid potassium salt, Diclofenac potassium salt
Molecular FormulaC14H10Cl2KNO2
Molecular Weight334.24
Purity99%
Boiling Point412ºC at 760 mmHg
Melting Point156-158ºC
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 15307-81-0 |
| Catalog No. | 2A-9010122 |
| Chinese Name | 双氯芬酸钾 |
| Synonyms | Diclofenic potassium; Potassium {2-[(2,6-dichlorophenyl)amino]phenyl}acetate; Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, potassium salt (1:1); potassium 2-(2-(2,6-dichlorophenylamino)phenyl)acetate; 2-((2,6-Dichlorophenyl)amino)benzeneacetic Acid Monopotassium Salt; Diclofenac potassium; 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid, potassium salt; Potassium [2-[(2,6-dichlorophenyl)amino]phenyl]acetate; MFCD00082254; Cataflam; CGP 45840B; CGP-45840B; 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid potassium salt, Diclofenac potassium salt |
| Molecular Formula | C14H10Cl2KNO2 |
| Molecular Weight | 334.24 |
| Purity | 99 |
| Boiling Point | 412ºC at 760 mmHg |
| Melting Point | 156-158ºC |
| Appearance | solid |
| Storage Condition | -20°C, inert gas |
| Application | Diclofenac potassium is a potent, non-selective anti-inflammatory agent and COX inhibitor with IC50 values of 4 and 1.3 nM for human COX-1 and COX-2, respectively, in CHO cells. The IC50 values of |
| HTC | 2922499990 |
| SMILES | [K+].Clc1c(c(ccc1)Cl)Nc2c(cccc2)CC(=O)[O-] |
| InChI | 1S/C14H11Cl2NO2.K/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1 |
| InChI Key | KXZOIWWTXOCYKR-UHFFFAOYSA-M |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/10122_1_15307_81_0.pdf |
| Use of | Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3]. Properties Articles54 Name diclofenac potassium Synonym More Synonyms Diclofenac potassium Biological Activity Description Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Human COX-2:1.3 nM (IC50, in CHO cells) Human COX-1:4 nM (IC50, in CHO cells) Ovine COX-2:0.84 nM (IC50) Ovine COX-1:5.1 nM (IC50) References [1]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [2]. Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80. [3]. Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95. Chemical & Physical Properties Exact Mass 332.972565 PSA 52.16000 LogP 3.10240 InChIKey KXZOIWWTXOCYKR-UHFFFAOYSA-M Safety Information GHS07, GHS09 Signal Word Warning Hazard Statements H302-H411 Precautionary Statements P301 + P312 + P330 Hazard Codes T: Toxic; Safety Phrases 61 RIDADR 2811.0 HS Code 2922499990 |
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