CAS Number78213-16-8
SynonymsN-ethylethanaminium {2-[(2,6-dichlorophenyl)amino]phenyl}acetate; Diclofenac diethylamine; n-ethylethanamine 2-[(2,6-dichlorophenyl)amino]benzeneacetate; UNII-6TGQ35Z71K; Diclofenac (diethylamine); MFCD01862249; Voltarol; {2-[(2,6-Dichlorophenyl)amino]phenyl}acetic acid - N-ethylethanamine (1:1); 2-[2-(2,6-dichloroanilino)phenyl]acetic acid; Diclofenac diethylammonium salt
Molecular FormulaC18H22Cl2N2O2
Molecular Weight369.29
Purity98%
Boiling Point412ºC at 760 mmHg
Melting Point145-148ºC
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 78213-16-8 |
| Catalog No. | 2A-9010121 |
| Chinese Name | 双氯芬酸二乙胺盐 |
| Synonyms | N-ethylethanaminium {2-[(2,6-dichlorophenyl)amino]phenyl}acetate; Diclofenac diethylamine; n-ethylethanamine 2-[(2,6-dichlorophenyl)amino]benzeneacetate; UNII-6TGQ35Z71K; Diclofenac (diethylamine); MFCD01862249; Voltarol; {2-[(2,6-Dichlorophenyl)amino]phenyl}acetic acid - N-ethylethanamine (1:1); 2-[2-(2,6-dichloroanilino)phenyl]acetic acid; Diclofenac diethylammonium salt |
| Molecular Formula | C18H22Cl2N2O2 |
| Molecular Weight | 369.29 |
| Purity | 98 |
| Boiling Point | 412ºC at 760 mmHg |
| Melting Point | 145-148ºC |
| Appearance | solid |
| Storage Condition | Store in inert gas; avoid air |
| Application | Diclofenac diethylamine is a potent, non-selective anti-inflammatory agent and an inhibitor of COX. In CHO cells, the IC50 values for human COX-1 and COX-2 are 4 nM and 1.3 nM respectively; the IC50 |
| HTC | 2942000000 |
| MDL Number | MFCD01862249 |
| SMILES | Clc1c(c(ccc1)Cl)Nc2c(cccc2)CC(=O)[O-].[N+H2](CC)CC |
| InChI | 1S/C14H11Cl2NO2.C4H11N/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;1-3-5-4-2/h1-7,17H,8H2,(H,18,19);5H,3-4H2,1-2H3 |
| InChI Key | ZQVZPANTCLRASL-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/10121_1_78213_16_8.pdf |
| Use of | Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively. Properties Name Diclofenac diethylamine Synonym More Synonyms Diclofenac diethylammonium salt Biological Activity Description Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively. Related Catalog Research Areas >> Inflammation/Immunology Human COX-2:1.3 nM (IC50, in CHO cells) Human COX-1:4 nM (IC50, in CHO cells) Ovine COX-2:0.84 μM (IC50) Ovine COX-1:5.1 μM (IC50) References [1]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [2]. Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80. [3]. Curcelli EC, et al. Beneficial effects of diclofenac therapy on serum lipids, oxidized low-density lipoprotein and antioxidant defenses in rats. Life Sci. 2008 Apr 9;82(15-16):892-8. Chemical & Physical Properties Exact Mass 368.105835 PSA 61.36000 LogP 5.44380 InChIKey ZQVZPANTCLRASL-UHFFFAOYSA-N Safety Information HS Code 2942000000 |
| Transport Info | Product Name: Diclofenac Diethylamine |
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